Physiology & Behavior, Год журнала: 2023, Номер 267, С. 114207 - 114207
Опубликована: Апрель 24, 2023
Язык: Английский
Cell Death and Disease, Год журнала: 2023, Номер 14(10)
Опубликована: Окт. 20, 2023
Abstract Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in inner walls vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke. The development atherosclerosis influenced variety factors, including age, genetics, lifestyle, underlying health conditions high pressure diabetes. Atherosclerotic stable form are slow growth, which leads luminal stenosis, with low embolic potential unstable form, contributes risk for thrombotic rapid clinical onset. In this complex scenario atherosclerosis, macrophages participate whole process, initiation, growth eventually rupture wound healing stages artery plaque formation. Macrophages exhibit heterogeneity plasticity, affect evolving microenvironment, e.g., leading excessive lipid accumulation, cytokine hyperactivation, hypoxia, apoptosis necroptosis. metabolic functional transitions response microenvironmental factors not only influence ongoing imminent responses within lesions but also directly dictate atherosclerotic progression regression. review, we discuss origin plaques, their phenotypic diversity, shifts, fate roles they play dynamic atherosclerosis. It describes how interact other cells, particularly T cells. Ultimately, targeting pathways involved macrophage polarization may innovative promising approaches precision medicine. Further insights into landscape biological features offer valuable information optimizing future treatment macrophages.
Язык: Английский
Процитировано
124
Cellular and Molecular Life Sciences, Год журнала: 2022, Номер 79(6)
Опубликована: Май 22, 2022
The inflammatory response of macrophages has been reported to play a critical role in atherosclerosis. state is modified by epigenetic reprogramming. m6A RNA methylation an modification RNAs. However, little known about the potential roles and underlying mechanisms macrophage inflammation. Herein, we showed that expression "writer" Mettl14 was increased coronary heart disease LPS-stimulated THP-1 cells. Knockdown promoted M2 polarization macrophages, inhibited foam cell formation decreased migration. Mechanistically, Myd88 IL-6 knockdown Through modification, regulated stability mRNA. Furthermore, affected transcription via distribution p65 nuclei rather than directly regulating through modification. In vivo, gene knockout significantly reduced development atherosclerotic plaques. Taken together, our data demonstrate plays vital inflammation atherosclerosis NF-κB/IL-6 signaling pathway, suggesting may be promising therapeutic target for clinical treatment
Язык: Английский
Процитировано
119
Medicina, Год журнала: 2022, Номер 58(2), С. 299 - 299
Опубликована: Фев. 16, 2022
Atherosclerosis is responsible for large cardiovascular mortality in many countries globally. It has been shown over the last decades that reduction of atherosclerotic progression a critical factor preventing future events. Low-density lipoproteins (LDL) have successfully targeted, and their one key measures patients with disease. LDL particles are pivotal formation plaques; yet, they quite heterogeneous, smaller, denser species most atherogenic. These greater arterial entry retention, higher susceptibility to oxidation, as well reduced affinity receptor. Increased proportion small, dense an integral part atherogenic lipoprotein phenotype, common form dyslipidemia associated insulin resistance. Recent data suggest both genetic epigenetic factors might induce expression this specific lipid pattern. In addition, typical finding increased was confirmed different categories elevated risk. Small, independent risk diseases, which emphasizes clinical importance quality quantity LDL. An effective management disease should take into account presence order prevent complications.
Язык: Английский
Процитировано
80
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Май 3, 2023
Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators responses. They involved in all stages atherosclerosis development progression, from plaque formation to transition into vulnerable plaques, considered important therapeutic targets. Increasing evidence suggests that modulation macrophage polarization can effectively control progression atherosclerosis. Herein, we explore role summarize emerging therapies for regulation polarization. Thus, aim inspire new avenues research disease mechanisms clinical prevention treatment
Язык: Английский
Процитировано
70
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Май 31, 2024
Abstract The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate system, macrophages play an essential initial inflammatory that occurs following injury, thereby inducing subsequent damage while also facilitating recovery. Meanwhile, diverse phenotypes and phenotypic alterations strongly associate with distinct types severity diseases, including coronary heart disease, valvular myocarditis, cardiomyopathy, failure, atherosclerosis aneurysm, which underscores importance investigating macrophage regulatory mechanisms within context specific diseases. Besides, recent strides single-cell sequencing technologies have revealed heterogeneity, cell–cell interactions, downstream therapeutic targets at higher resolution, brings new perspectives into macrophage-mediated potential Remarkably, myocardial fibrosis, prevalent characteristic most cardiac remains formidable clinical challenge, necessitating profound investigation impact on fibrosis In this review, we systematically summarize functional plasticity diseases unprecedented insights introduced by technologies, focus different causes characteristics especially relationship between inflammation (myocardial infarction, pressure overload, dilated diabetic cardiomyopathy aging) vascular injury (atherosclerosis aneurysm). Finally, highlight preclinical/clinical targeting strategies translational implications.
Язык: Английский
Процитировано
67
International Journal of Cardiology, Год журнала: 2024, Номер 418, С. 132663 - 132663
Опубликована: Окт. 18, 2024
Язык: Английский
Процитировано
19
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 10, 2025
Obesity is a rapidly growing health problem worldwide, affecting both adults and children increasing the risk of chronic diseases such as type 2 diabetes, hypertension cardiovascular disease (CVD). In addition, obesity closely linked to kidney (CKD) by either exacerbating diabetic complications or directly causing damage. Obesity-related CKD characterized proteinuria, lipid accumulation, fibrosis glomerulosclerosis, which can gradually impair function. Among immune cells innate adaptive response involved in pathogenesis obesity-related diseases, macrophages play crucial role inflammation associated with CKD. obese individuals, enter pro-inflammatory state known M1 polarization, contributes inflammation. This polarization promotes tissue damage, fibrosis, leading progressive loss macrophage-induced oxidative stress key feature it also cell damage Macrophages contribute insulin resistance diabetes releasing inflammatory molecules that glucose metabolism, complicating management patients. Hypertension atherosclerosis, are often obesity, progression via pathways. influence blood pressure regulation vascular inflammation, particularly renin-angiotensin system. accumulate arterial plaques, plaque instability, may increase CVD review focuses on involvement highlights their critical link between other pathologies. Targeting macrophage ensuing could be an effective therapeutic strategy for related improve outcomes patients disease.
Язык: Английский
Процитировано
4
Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 11
Опубликована: Янв. 14, 2025
Cardiometabolic diseases (CMD) are leading causes of death and disability worldwide, with complex pathophysiological mechanisms in which inflammation plays a crucial role. This review aims to elucidate the molecular cellular within inflammatory microenvironment atherosclerosis, hypertension diabetic cardiomyopathy. In oxidized low-density lipoprotein (ox-LDL) pro-inflammatory cytokines such as Interleukin-6 (IL-6) Tumor Necrosis Factor-alpha (TNF-α) activate immune cells contributing foam cell formation arterial wall thickening. Hypertension involves activation renin-angiotensin system (RAS) alongside oxidative stress-induced endothelial dysfunction local mediated by T cells. cardiomyopathy, high-glucose environment leads accumulation advanced glycation end products (AGEs), activating Receptor for Advanced Glycation Endproducts (RAGE) triggering responses that further damage cardiac microvascular function. summary, different types metabolic cardiovascular diverse; understanding these deeply will aid developing more effective individualized treatment strategies.
Язык: Английский
Процитировано
3
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Июнь 20, 2022
In recent years, studies of macrophage polarization in atherosclerosis have become an intense area research. However, there are few bibliometric analyses regarding this area. review, we used CiteSpace 5.8.R3 and VOSviewer 1.6.16 software to perform text mining knowledge-map analysis. We explored the development process, knowledge structure, research hotspots, potential trends using a analysis provide researchers with macroscopic view field. The concerning were downloaded from Web Science Core Collection. A total 781 identified published by 954 institutions 51 countries/regions. number increased over time. Arteriosclerosis Thrombosis Vascular Biology highest articles was top co-cited journal. De Winther most prolific researcher, Moore had co-citations. author co-occurrence map illustrated that active cooperation among researchers. productive countries United States China. Amsterdam University, Harvard Maastricht University three Keyword Co-occurrence, Clusters, Burst showed “inflammation,” “monocyte,” “NF kappa B,” “mechanism,” “foam cell” appeared frequency studies. “Oxidative stress,” “coronary heart disease,” “prevention” strongest citation burst keywords 2019 2021.
Язык: Английский
Процитировано
59
Biology, Год журнала: 2023, Номер 12(5), С. 694 - 694
Опубликована: Май 9, 2023
Macrophages are a type of immune cell distributed throughout all tissues an organism. Allograft inflammatory factor 1 (AIF1) is calcium-binding protein linked to the activation macrophages. AIF1 key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several type-specific functions. plays important roles development diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases neurological disorders, transplants. In this review, we present comprehensive review known structure, functions role diseases.
Язык: Английский
Процитировано
30