Life Sciences,
Год журнала:
2024,
Номер
351, С. 122823 - 122823
Опубликована: Июнь 11, 2024
Cardiovascular
diseases
(CVDs)
are
a
leading
cause
of
mortality
worldwide,
primarily
affecting
the
heart
and
blood
vessels,
with
atherosclerosis
being
major
contributing
factor
to
their
onset.
Epidemiological
clinical
studies
have
linked
high
levels
low-density
lipoprotein
(LDL)
emanating
from
distorted
cholesterol
homeostasis
as
its
predisposing
factor.
Cholesterol
homeostasis,
which
involves
maintaining
balance
in
body
level,
is
mediated
by
several
proteins
or
receptors,
transcription
factors,
even
genes,
regulating
influx
(through
dietary
intake
de
novo
synthesis)
efflux
(by
conversion
bile
acids).
Previous
knowledge
about
CVDs
management
has
evolved
around
modulating
these
receptors'
activities
through
synthetic
small
molecules/antibodies,
limited
interest
natural
products.
The
central
roles
cholesteryl
ester
transfer
protein
(CETP),
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9),
cytochrome
P450
family
7
subfamily
A
member
1
(CYP7A1),
among
other
fostered
growing
scientific
interests
understanding
more
on
regulatory
potential
drug
targets.
We
present
up-to-date
contributions
CETP,
PCSK9,
CYP7A1
toward
CVDs,
highlighting
successes
failures
molecules/antibodies
modulate
activities.
In
recommendation
for
new
direction
improve
cardiovascular
health,
we
presented
recent
findings
products
(including
functional
food,
plant
extracts,
phytochemicals,
bioactive
peptides,
therapeutic
carbohydrates)
that
also
PCSK-9,
CYP7A1,
emphasized
need
research
efforts
redirected
unraveling
potentials
at
trial
level
CVD
management.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
25(1), С. 388 - 388
Опубликована: Дек. 27, 2023
Atherosclerosis
is
a
chronic
inflammatory
disease
driven
by
lipid
accumulation
in
the
arteries,
leading
to
narrowing
and
thrombosis
that
causes
mortality.
Emerging
evidence
has
confirmed
atherosclerosis
affects
younger
people
involved
majority
of
deaths
worldwide.
EVs
are
associated
with
critical
steps
atherosclerosis,
cholesterol
metabolism,
immune
response,
endothelial
dysfunction,
vascular
inflammation,
remodeling.
Endothelial
cell-derived
can
interact
platelets
monocytes,
thereby
influencing
atherosclerotic
plaque
destabilization,
formation
thrombus.
potential
diagnostic
prognostic
biomarkers
(AS)
cardiovascular
(CVD).
Importantly,
derived
from
stem/progenitor
cells
essential
mediators
cardiogenesis
cardioprotection
may
be
used
regenerative
medicine
tissue
engineering.
Journal of Cachexia Sarcopenia and Muscle,
Год журнала:
2024,
Номер
15(3), С. 1199 - 1208
Опубликована: Апрель 21, 2024
Endothelial
dysfunction
and
peripheral
arterial
disease
(PAD),
which
disturb
skeletal
muscle
microperfusion,
are
highly
prevalent
in
patients
with
chronic
kidney
(CKD).
We
evaluated
the
association
of
endothelial
PAD
sarcopenia
non-dialysis
CKD.
Life Sciences,
Год журнала:
2024,
Номер
351, С. 122823 - 122823
Опубликована: Июнь 11, 2024
Cardiovascular
diseases
(CVDs)
are
a
leading
cause
of
mortality
worldwide,
primarily
affecting
the
heart
and
blood
vessels,
with
atherosclerosis
being
major
contributing
factor
to
their
onset.
Epidemiological
clinical
studies
have
linked
high
levels
low-density
lipoprotein
(LDL)
emanating
from
distorted
cholesterol
homeostasis
as
its
predisposing
factor.
Cholesterol
homeostasis,
which
involves
maintaining
balance
in
body
level,
is
mediated
by
several
proteins
or
receptors,
transcription
factors,
even
genes,
regulating
influx
(through
dietary
intake
de
novo
synthesis)
efflux
(by
conversion
bile
acids).
Previous
knowledge
about
CVDs
management
has
evolved
around
modulating
these
receptors'
activities
through
synthetic
small
molecules/antibodies,
limited
interest
natural
products.
The
central
roles
cholesteryl
ester
transfer
protein
(CETP),
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9),
cytochrome
P450
family
7
subfamily
A
member
1
(CYP7A1),
among
other
fostered
growing
scientific
interests
understanding
more
on
regulatory
potential
drug
targets.
We
present
up-to-date
contributions
CETP,
PCSK9,
CYP7A1
toward
CVDs,
highlighting
successes
failures
molecules/antibodies
modulate
activities.
In
recommendation
for
new
direction
improve
cardiovascular
health,
we
presented
recent
findings
products
(including
functional
food,
plant
extracts,
phytochemicals,
bioactive
peptides,
therapeutic
carbohydrates)
that
also
PCSK-9,
CYP7A1,
emphasized
need
research
efforts
redirected
unraveling
potentials
at
trial
level
CVD
management.
