Novel Antidiabetic Drugs and Risk of Venous Thromboembolism: A Literature Review

Seminars in Thrombosis and Hemostasis, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Novel antidiabetic drugs, particularly sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, have significantly transformed the management landscape for type diabetes mellitus, cardiovascular diseases, chronic kidney owing to their well-established cardiorenal protective effects. Given shared risk factors comorbidities, it is relevant consider potential of venous thromboembolism (VTE) in individuals prescribed these novel medications. This literature review aims summarize currently available evidence on VTE associated with including GLP-1 dipeptidyl-peptidase IV (DPP-4) inhibitors, SGLT2 inhibitors. Following a comprehensive search PubMed using keywords backward reference searching, we identified 25 publications that directly reported associations between medications risk. Findings from studies, seven meta-analyses, reveal inconsistent results: some studies suggest agonists or DPP-4 may be increased VTE, whereas do not appear even factor. A notable limitation existing significant challenge posed by confounding observational while randomized controlled trials (RCTs) often concluded limited number events, if was studied. Furthermore, all focused primary leaving an important knowledge gap regarding whether drugs influence efficacy safety anticoagulants used preventing recurrence. Addressing gaps presents avenue future research.

Язык: Английский

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Potential α-glucosidase inhibitors from cultures of Biscogniauxia capnodes SWUF15-40 fungus

Journal of Natural Medicines, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Язык: Английский

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The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion

Metabolites, Год журнала: 2022, Номер 12(5), С. 420 - 420

Опубликована: Май 7, 2022

The enteroendocrine system of the gut regulates energy homeostasis through release hormones. Of gut-derived hormones, GLP-1 is particularly interesting, as analogs hormone have proven to be highly effective for treatment type 2 diabetes mellitus and obesity. Observations on increased levels following gastric bypass surgery enhanced interest in endogenous secretion highlighted potential therapy. macronutrients their digestive products stimulate various mechanisms that we only begun understand. From findings obtained from different experimental models, now strong indications a role both Sodium-Glucose Transporter 1 (SGLT1) K+ATP channel carbohydrate-induced secretion. For fat, free fatty acid receptor FFA1 G-protein-coupled GPR119 been linked proteins, Peptide (Pept1) Calcium-Sensing Receptor (CaSR) are thought mediate However, attempts at clinical application these unsuccessful, more work needed before fully understand nutrient-induced

Язык: Английский

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GLP-1R Signaling and Functional Molecules in Incretin Therapy

Molecules, Год журнала: 2023, Номер 28(2), С. 751 - 751

Опубликована: Янв. 11, 2023

Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and blood glucose regulation has been extensively studied. Numerous drugs targeting have entered clinical treatment. However, novel functional molecules with reduced side effects enhanced efficacy are still in high demand. In this review, we summarize the basis of signaling, how it involved treatment T2DM. We review incretin therapy various stages trials. also outline current strategies emerging techniques that furthering development T2DM other metabolic diseases.

Язык: Английский

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Natural products from plants targeting key enzymes for the future development of antidiabetic agents

Natural Product Reports, Год журнала: 2023, Номер 40(7), С. 1198 - 1249

Опубликована: Янв. 1, 2023

This review summarizes plant metabolites targeting crucial enzymes involved in glucose homeostasis useful for antidiabetic drug development.

Язык: Английский

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Arylureidoaurones: Synthesis, in vitro α-glucosidase, and α-amylase inhibition activity

Bioorganic Chemistry, Год журнала: 2023, Номер 139, С. 106709 - 106709

Опубликована: Июль 1, 2023

Язык: Английский

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Recent advances and structure-activity relationship studies of DPP-4 inhibitors as anti-diabetic agents

Bioorganic Chemistry, Год журнала: 2024, Номер 146, С. 107277 - 107277

Опубликована: Март 12, 2024

Язык: Английский

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Synthesis, in vitro potency of inhibition, enzyme kinetics and in silico studies of quinoline-based α-glucosidase inhibitors

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 4, 2024

Abstract Diabetes mellitus is a multifactorial global health disorder that rising at an alarming rate. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes to target α-glucosidase, which catalyzes starch hydrolysis in the intestine. In attempt find potential α-glucosidase inhibitors, series of twenty new quinoline linked benzothiazole hybrids ( 8a–t ) were synthesized good yields from suitable reaction procedures and their chemical structures analyzed by 1 HNMR, 13 CNMR, IR, ESI–MS analysis. The derivatives further screened activity against α-glucosidase. Among them, compounds 8b , 8h 8n 8o exhibited remarkable inhibitory IC 50 values ranging 38.2 ± 0.3 79.9 1.2 µM compared standard drug acarbose (IC = 750.0 2.0 µM). Enzyme kinetic studies most active compound indicated non-competitive inhibition K i value µM. Moreover, homology modeling, molecular docking dynamics simulation conducted reveal key interactions between targeted enzyme. These results are complementary experimental observations. order predict druggability novel derivatives, pharmacokinetic properties also applied. findings could be useful design development inhibitors.

Язык: Английский

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Insights on effects of Wnt pathway modulation on insulin signaling and glucose homeostasis for the treatment of type 2 diabetes mellitus: Wnt activation or Wnt inhibition?

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 129634 - 129634

Опубликована: Янв. 1, 2024

Язык: Английский

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A look at duodenal mucosal resurfacing: Rationale for targeting the duodenum in type 2 diabetes

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(6), С. 2017 - 2028

Опубликована: Март 4, 2024

Abstract Affecting 5%–10% of the world population, type 2 diabetes (T2DM) is firmly established as one major health burdens modern society. People with T2DM require long‐term therapies to reduce blood glucose, an approach that can mitigate vascular complications. However, fewer than half those living reach their glycaemic targets despite availability multiple oral and injectable medications. Adherence access medications are barriers contributing suboptimal treatment. The gastrointestinal tract has recently emerged a target for treating altering underlying disease course. Preclinical clinical analyses have elucidated changes in mucosal layer duodenum potentially caused by dietary excess obesity, which seem be prevalent among individuals metabolic disease. Supporting these findings, gastric bypass, surgical procedure removes from intestinal nutrient flow, remarkable effects improve, often cause remission of, diabetes. From this perspective, we explore rationale targeting duodenal resurfacing (DMR). We examine physiology its emerging role pathogenesis, DMR potential treatment T2DM, current data surrounding DMR. Importantly, been demonstrated change abnormalities common obesity Given multifactorial aetiology understanding proximate contributors pathogenesis opens door rethinking therapeutic approaches symptom management toward modification.

Язык: Английский

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