Опубликована: Сен. 20, 2023
A virtual experiment conducted using the ICP-MS TuneSim software served as basis for studies that compared applicability of central composite design with Box–Behnken in analytical chemistry applications. The insights gathered from these experiments were used real-life electroanalytical tests, including determination germanium and antioxidant properties herbal infusions. experimental interpretation results performed Statistica software.
Язык: Английский
Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127202 - 127202
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Pharmacological Research - Modern Chinese Medicine, Год журнала: 2023, Номер 9, С. 100331 - 100331
Опубликована: Ноя. 27, 2023
Ginkgo biloba L. (Ginkgoaceae), known as a "living fossil," has long history of medicinal use. Both its leaves and nuts have been widely prescribed for the treatment various ailments, including pulmonary diseases, alcohol abuse, bladder inflammation, heart lung dysfunction, skin infections. Currently, there are different forms G. available in market, extracts isolated compounds such terpenoids, flavonoids, bioflavonoids, organic acids. Despite significant importance this plant, is lack updated reviews encompassing pharmacology other relevant aspects. Therefore, objective review to collect analyze existing literature on phytochemical, ethnobotanical, pharmacological aspects biloba. Electronic databases PubMed, Embase, Scopus, Google Scholar were searched keywords "Ginkgo biloba" or "ginkgo" combination with "phytochemistry", "ethnobotany", "pharmacology", "nervous system", "cardiovascular", etc. articles. There was no language restriction. Retrieved studies showed that from beneficial activities cerebrovascular, nervous, cardiovascular, endocrine, muscular skeletal, renal, respiratory, digestive, immunity systems. Numerous vitro vivo conducted investigate therapeutic potential improvement diseases. Additionally, substantial body clinical research preparations compounds. However, further investigations, particularly human-controlled trials, recommended determine efficacy safety These trials would provide more robust evidence regarding benefits risks associated use settings.
Язык: Английский
Процитировано
12
The American Journal of Chinese Medicine, Год журнала: 2024, Номер 52(03), С. 625 - 666
Опубликована: Янв. 1, 2024
The pathogenesis of Alzheimer's disease (AD), a degenerative the central nervous system, remains unclear. main manifestations AD include cognitive and behavioral disorders, neuropsychiatric symptoms, neuroinflammation, amyloid plaques, neurofibrillary tangles. However, current drugs for once dementia stage has been reached only treat symptoms do not delay progression, research development targeted have bottleneck. Thus, other treatment options are needed. Bioactive ingredients derived from plants promising therapeutic agents. Specifically,
Язык: Английский
Процитировано
4
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 3, 2025
Diabetic kidney disease (DKD) has become the leading cause of end-stage renal in world. However, current conventional approaches have not yet achieved satisfactory efficacy. As one most influential products botanical medicine, Ginkgo biloba L. leaves extract (GBE) demonstrates various pharmacological effects on DKD and is gradually used as an adjunctive therapy for this disease. A comprehensive analysis necessary to evaluate efficacy safety GBE adjuvant treatment DKD. This meta-analysis aimed a supplementary renin-angiotensin-aldosterone system inhibitors patients, providing reference subsequent research clinical practice. study been registered PROSPERO CRD42023455792. Ten databases were searched from their inception 21 July 2023. Randomized controlled trials about included. Review Manager 5.4 Stata 16.0 employed conduct analysis. Heterogeneity was assessed through χ2 test I2 test, effect model chosen accordingly. Meta-regression subgroup performed investigate sources heterogeneity influence different factor levels The publication bias evaluated with funnel plot Egger's evidence quality by Grading Recommendations Assessment, Development Evaluation (GRADE) method. total 41 studies 3,269 patients finally enrolled study. None included reported whether or cardiovascular progression events occurred. Compared angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) alone, combination more beneficial improving urinary albumin excretion rate (UAER) [mean difference (MD) = -22.99 μg/min, 95% confidence interval (CI): -27.66 -18.31, p < 0.01], serum creatinine (SCr) [MD -8.30 μmol/L, CI: -11.55 -5.05, blood urea nitrogen (BUN) -0.77 mmol/L, -1.04 -0.49, 24-hour protein (24hUTP) -0.28 g/d, -0.35 -0.22, cystatin C (Cys-C) -0.30 mg/L, -0.43 -0.17, cholesterol (TC) -0.69 -1.01 -0.38, triglyceride (TG) -0.40 -0.56 -0.23, low-density lipoprotein (LDL-C) -0.97 -1.28 -0.65, fasting glucose (FBG) -0.54 -0.05, 0.02], hematocrit -4.58%, -5.25 -3.90, 0.01] fibrinogen -0.80 g/L, -1.12 -0.47, 0.01]. No significant improvement found 2-hour postprandial (2hPG), glycated hemoglobin (HbA1c), diastolic pressure (DBP) systolic (SBP). detected adverse events. Combining ACEI/ARB may improve UAER, SCr, BUN, 24hUTP, Cys-C, TC, TG, LDL-C, patients. It also seems oxidative stress inflammation but minimal impact pressure. Combined generally tolerated, monitoring remains essential during its use. More long-term high-quality in-depth molecular are still provide stronger regarding benefits https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=455792, identifier
Язык: Английский
Процитировано
0
The World Journal of Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 1 - 11
Опубликована: Фев. 3, 2025
Mild dementia is distressing for patients and their relatives. Due to its chronic progressive nature, healthcare systems are at risk of being overwhelmed by the increasing number affected patients. Thus, there a need safe well-tolerated treatments that can be initiated earliest stages. This meta-analysis clinical trials aimed assess treatment effects Ginkgo biloba extract EGb 761 in with mild dementia. Eligible randomised placebo-controlled were included this meta-analysis. Data (defined as SKT Short Cognitive Performance Test total scores from 9 15) selected. The was performed pooled data four eligible comprising 782 Treatment 240 mg daily significantly superior placebo cognition (p = 0.04), global assessment 0.01), activities living 0.01) quality life 0.02). Standardised medium large. frequency adverse events alike treated 0.66). demonstrates benefit terms cognition, living, life.
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(4), С. 922 - 922
Опубликована: Фев. 17, 2025
This study examines the intricacies of Alzheimer's disease (AD), its origins, and potential advantages various herbal extracts natural compounds for enhancing memory cognitive performance. Future studies into AD treatments are encouraged by review's demonstration effectiveness phytoconstituents that were extracted from a number plants. In addition to having many beneficial effects, such as improved cholinergic function, medicines also much less harmful, more readily available, easier use than other treatments. They pass without difficulty through blood-brain barrier (BBB). focused on substances their effects using academic databases identify peer-reviewed published between 2015 2024. According literature review, 66 isolated 21 distinct plants have shown efficacy, which could be encouraging future research therapies. Since most clinical trials produce contradictory results, suggests larger-scale with longer treatment durations necessary validate or refute therapeutic efficacy
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 5, 2025
This systematic review and meta-analysis aims to assess the efficacy of GBE in treatment IPF by evaluating its impact on total effective rate, blood gas analysis, pulmonary function tests, markers inflammation fibrosis. We conducted a comprehensive search across seven databases, including PubMed, EMBASE, Web Science, CNKI, Wanfang DATA, VIP, CBM, without restrictions publication date. Randomized controlled trials (RCTs) that investigated effects patients were eligible for inclusion. Relevant literature was screened, data included studies extracted quality assessment according Risk bias tool. A 14 RCTs involving 1043 analysis. significantly improved arterial oxygen partial pressure, saturation, forced vital capacity, expiratory volume one second, maximum voluntary ventilation, 6-min walk test compared control group. Additionally, there significant reduction carbon dioxide interleukin-4, hyaluronan, laminin levels. may offer therapeutic benefits improving respiratory function, modulating inflammation, affecting fibrosis markers. These findings support potential use as an adjunct therapy suggest further large-scale, multicenter are warranted confirm safety.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2025, Номер 141, С. 156565 - 156565
Опубликована: Март 7, 2025
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 119010 - 119010
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8108 - 8108
Опубликована: Июль 25, 2024
Inflammatory processes in the brain can exert important neuroprotective functions. However, neurological and psychiatric disorders, it is often detrimental due to chronic microglial over-activation dysregulation of cytokines chemokines. Growing evidence indicates emerging yet prominent pathophysiological role neuroinflammation development progression these disorders. Despite recent advances, there still a pressing need for effective therapies, targeting promising approach. Therefore, this study, we investigated anti-neuroinflammatory potential marketed quantified proprietary herbal extract
Язык: Английский
Процитировано
2