Arabian Journal of Chemistry,
Год журнала:
2023,
Номер
16(7), С. 104840 - 104840
Опубликована: Март 24, 2023
In
the
absence
of
appearance
features,
it
is
becoming
increasingly
difficult
to
accurately
distinguish
botanical
herbal
powders
from
different
families
or
parts
plant.
this
study,
we
explored
biomarkers
with
neuroprotective
effects
in
multi-parts
ginseng
based
on
metabolite
content
changes
and
biological
functions.
First,
using
1H
NMR
LC-MS
metabolomics
techniques
multivariate
statistical
analysis
analyze
differential
metabolites
(DMs)
main
root
(TR),
lateral
(LR)
Rhizome
(RZ).
Also,
14
network
pharmacology
yielded
23
core
targets
associated
diseases,
KEGG
pathway
was
enriched
for
117
signaling
pathways
184
enrichment
processes
were
shown
GO
analysis.
Combined
correlation
primary
(PDMs)
secondary
(SDMs)
activity,
finally
identified
three
ginseng,
namely
sucrose,
ginsenoside
Rb1,
Rb3.
Finally,
validated
by
molecular
docking
SH-SY5Y
survival,
results
showed
that
Rb1
Rb3
exhibited
favorable
activity
The
study
reveal
overall
differences
DMs
can
help
identify
powder,
avoid
illegal
substitution
when
used
medicine.
At
same
time,
also
provides
a
reference
method
screening
traditional
Chinese
Frontiers in Neuroscience,
Год журнала:
2022,
Номер
16
Опубликована: Авг. 23, 2022
Spinal
cord
injury
(SCI)
is
a
devastating
disorder
of
the
central
nervous
system
(CNS).
It
mainly
caused
by
trauma
and
reduces
quality
life
affected
individual.
Ginsenosides
are
safe
effective
traditional
Chinese
medicines
(TCMs),
their
efficacy
against
SCI
being
increasingly
researched
in
many
countries,
especially
China
Korea.
This
systematic
review
evaluated
neuroprotective
effects
ginsenosides
elucidated
properties.
Methods
All
experimental
information
summaries
used
this
were
acquired
from
peer-reviewed
articles
relevant
fields.
The
PubMed,
Web
Science,
Google
Scholar,
National
Knowledge
Infrastructure
databases
searched
for
articles.
Information
on
manual
classification
selection
that
protect
included
review.
Results
A
literature
survey
yielded
studies
reporting
several
properties
ginsenosides,
including
anti-inflammation,
anti-apoptosis,
anti-oxidative
stress,
inhibition
glial
scar
formation.
Conclusion
In
review,
we
discuss
mechanisms
action
different
exert
SCI.
These
results
suggest
after
further
verification
future,
may
be
as
adjunctive
therapy
to
promote
neurological
recovery.
Phytomedicine,
Год журнала:
2023,
Номер
126, С. 155073 - 155073
Опубликована: Сен. 20, 2023
Cervical
spondylotic
myelopathy
(CSM)
is
a
degenerative
pathology
that
affects
both
upper
and
lower
extremity
mobility
sensory
function,
causing
significant
pressure
on
patients
society.
Prior
research
has
suggested
ginsenosides
may
have
neuroprotective
properties
in
central
nervous
system
diseases.
However,
the
efficacy
mechanism
of
for
CSM
yet
to
be
investigated.
Arabian Journal of Chemistry,
Год журнала:
2023,
Номер
16(7), С. 104840 - 104840
Опубликована: Март 24, 2023
In
the
absence
of
appearance
features,
it
is
becoming
increasingly
difficult
to
accurately
distinguish
botanical
herbal
powders
from
different
families
or
parts
plant.
this
study,
we
explored
biomarkers
with
neuroprotective
effects
in
multi-parts
ginseng
based
on
metabolite
content
changes
and
biological
functions.
First,
using
1H
NMR
LC-MS
metabolomics
techniques
multivariate
statistical
analysis
analyze
differential
metabolites
(DMs)
main
root
(TR),
lateral
(LR)
Rhizome
(RZ).
Also,
14
network
pharmacology
yielded
23
core
targets
associated
diseases,
KEGG
pathway
was
enriched
for
117
signaling
pathways
184
enrichment
processes
were
shown
GO
analysis.
Combined
correlation
primary
(PDMs)
secondary
(SDMs)
activity,
finally
identified
three
ginseng,
namely
sucrose,
ginsenoside
Rb1,
Rb3.
Finally,
validated
by
molecular
docking
SH-SY5Y
survival,
results
showed
that
Rb1
Rb3
exhibited
favorable
activity
The
study
reveal
overall
differences
DMs
can
help
identify
powder,
avoid
illegal
substitution
when
used
medicine.
At
same
time,
also
provides
a
reference
method
screening
traditional
Chinese
