Phytomedicine,
Journal Year:
2023,
Volume and Issue:
126, P. 155073 - 155073
Published: Sept. 20, 2023
Cervical
spondylotic
myelopathy
(CSM)
is
a
degenerative
pathology
that
affects
both
upper
and
lower
extremity
mobility
sensory
function,
causing
significant
pressure
on
patients
society.
Prior
research
has
suggested
ginsenosides
may
have
neuroprotective
properties
in
central
nervous
system
diseases.
However,
the
efficacy
mechanism
of
for
CSM
yet
to
be
investigated.
Frontiers in Neuroscience,
Journal Year:
2022,
Volume and Issue:
16
Published: Aug. 23, 2022
Spinal
cord
injury
(SCI)
is
a
devastating
disorder
of
the
central
nervous
system
(CNS).
It
mainly
caused
by
trauma
and
reduces
quality
life
affected
individual.
Ginsenosides
are
safe
effective
traditional
Chinese
medicines
(TCMs),
their
efficacy
against
SCI
being
increasingly
researched
in
many
countries,
especially
China
Korea.
This
systematic
review
evaluated
neuroprotective
effects
ginsenosides
elucidated
properties.
Methods
All
experimental
information
summaries
used
this
were
acquired
from
peer-reviewed
articles
relevant
fields.
The
PubMed,
Web
Science,
Google
Scholar,
National
Knowledge
Infrastructure
databases
searched
for
articles.
Information
on
manual
classification
selection
that
protect
included
review.
Results
A
literature
survey
yielded
studies
reporting
several
properties
ginsenosides,
including
anti-inflammation,
anti-apoptosis,
anti-oxidative
stress,
inhibition
glial
scar
formation.
Conclusion
In
review,
we
discuss
mechanisms
action
different
exert
SCI.
These
results
suggest
after
further
verification
future,
may
be
as
adjunctive
therapy
to
promote
neurological
recovery.
Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(7), P. 104840 - 104840
Published: March 24, 2023
In
the
absence
of
appearance
features,
it
is
becoming
increasingly
difficult
to
accurately
distinguish
botanical
herbal
powders
from
different
families
or
parts
plant.
this
study,
we
explored
biomarkers
with
neuroprotective
effects
in
multi-parts
ginseng
based
on
metabolite
content
changes
and
biological
functions.
First,
using
1H
NMR
LC-MS
metabolomics
techniques
multivariate
statistical
analysis
analyze
differential
metabolites
(DMs)
main
root
(TR),
lateral
(LR)
Rhizome
(RZ).
Also,
14
network
pharmacology
yielded
23
core
targets
associated
diseases,
KEGG
pathway
was
enriched
for
117
signaling
pathways
184
enrichment
processes
were
shown
GO
analysis.
Combined
correlation
primary
(PDMs)
secondary
(SDMs)
activity,
finally
identified
three
ginseng,
namely
sucrose,
ginsenoside
Rb1,
Rb3.
Finally,
validated
by
molecular
docking
SH-SY5Y
survival,
results
showed
that
Rb1
Rb3
exhibited
favorable
activity
The
study
reveal
overall
differences
DMs
can
help
identify
powder,
avoid
illegal
substitution
when
used
medicine.
At
same
time,
also
provides
a
reference
method
screening
traditional
Chinese
Journal of Ginseng Research,
Journal Year:
2023,
Volume and Issue:
48(1), P. 103 - 111
Published: Oct. 2, 2023
Ginseng
(Panax
ginseng
Mayer)
is
an
important
natural
medicine.
However,
a
long
culture
period
and
challenging
quality
control
requirements
limit
its
further
use.
Although
artificial
cultivation
can
yield
sustainable
medicinal
supply,
research
on
the
association
between
transplantation
chaining
of
metabolic
networks,
especially
regulation
ginsenoside
biosynthetic
pathways,
limited.
Herein,
we
performed
Liquid
chromatography
tandem
mass
spectrometry
based
metabolomic
measurements
to
evaluate
accumulation
categorise
differentially
abundant
metabolites
(DAMs).
Transcriptome
using
Illumina
Platform
were
then
conducted
probe
landscape
genetic
alterations
in
at
various
ages
mode.
Using
pathway
data
crosstalk
DAMs
obtained
by
MapMan,
constructed
profile
Ginseng.
Accumulation
active
ingredients
was
not
obvious
during
first
4
years
(in
field),
but
following
transplantation,
content
increased
significantly
from
6−8
wild).
Glycerolipid
metabolism
Glycerophospholipid
most
significant
as
Lipids
lipid-like
molecule
affected
ginsenosides.
Starch
sucrose
pathways
growth.
This
study
expands
our
understanding
network
features
specific
compounds
different
growth
stages
this
perennial
herbaceous
plant
when
growing
The
findings
provide
basis
for
selecting
optimal
transplanting
time.
