Опубликована: Март 20, 2025
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Апрель 25, 2023
Introduction:Phellinus igniarius (P. igniarius) (Sanghuang) is a widely used traditional Chinese medicine fungus, and its natural products have great potential for clinical application in immune enhancement. This study aimed to explore the immune-enhancing activity underlying mechanisms of polysaccharides flavonoids derived from Phellinus provide theoretical experimental basis development novel drugs. Methods: Wild P. YASH1 Loess Plateau Yan'an region was collected, total were extracted, isolated identified mycelium sporophore. In vitro antioxidant detected through scavenging hydroxyl radicals capacity. Cell Counting Kit-8 trypan blue detection kit detect effect extract on proliferation phagocytosis ability cells. To assess drugs cytokine secretion by cells recovery immunocompromised mice, expression interleukin (IL)-2, IL-6, interferon (IFN)-γ, tumor necrosis factor (TNF)-α examined at cellular animal levels. The species composition, abundance gut microbiota altered content short-chain fatty acids feces analyzed elucidate possible 16S ribosomal RNA (rRNA) amplifiers sequencing liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: Both or sporophore had may stimulate IL-2, IFN-γ while inhibiting TNF-α increasing IFN- γ levels mice. Furthermore, showed different effects metabolic response intestinal (SCFAs) use these remarkably changed composition flora Discussion: Polysaccharides activity, they affect promotion cell proliferation, stimulation secretion, inhibition enhance immunity mice SCFAs.
Язык: Английский
Процитировано
11
Current Neuropharmacology, Год журнала: 2023, Номер 22(7), С. 1156 - 1168
Опубликована: Авг. 18, 2023
Autism spectrum disorder (ASD) includes a heterogeneous group of complex neurodevelopmental disorders characterized by atypical behaviors with two core pathological manifestations: deficits in social interaction/communication and repetitive behaviors, which are associated disturbed redox homeostasis. Modulation cellular resilience mechanisms induced low levels stressors represents novel approach for the development therapeutic strategies, this context, neuroprotective effects wide range polyphenol compounds have been demonstrated several vitro vivo studies thoroughly reviewed. Mushrooms used traditional medicine many years long list properties, including antitumor, immunomodulatory, antioxidant, antiviral, antibacterial, hepatoprotective effects. Our recent strikingly indicated presence polyphenols nutritional mushrooms their protective different models neurodegenerative humans rats. Although exerted through multiple mechanisms, increasing attention is focusing on capacity to induce endogenous defense systems modulating signaling processes such as nuclear factor erythroid 2 related (Nrf2) factor-kappa B (NF-κB) pathways. Here we discuss role hormesis its modulation hormetic nutrients ASD.
Язык: Английский
Процитировано
11
Cells, Год журнала: 2024, Номер 13(6), С. 510 - 510
Опубликована: Март 14, 2024
Chemoresistance is a challenge in cancer treatment, limiting the effectiveness of chemotherapy. Mushroom extracts have shown potential as treatments for therapies, offering possible solution to overcome chemoresistance. This systematic review aimed explore role mushroom enhancing chemotherapy and reversing chemoresistance cells. We searched PubMed, Web Science Scopus databases, following PRISMA guidelines, registered on PROSPERO. The acted by inhibiting proliferation cells, well effect mechanisms which they included regulating anti-apoptotic proteins, JAK2/STAT3 pathway, ERK1/2 modulating microRNAs p-glycoprotein. These results highlight modulate multiple order improve efficacy work sheds light use an aid combat Although studies are limited, diversity mushrooms their bioactive compounds show promising innovative strategies treat more effectively. It crucial carry out further better understand therapeutic
Язык: Английский
Процитировано
4
Applied Food Research, Год журнала: 2025, Номер unknown, С. 100694 - 100694
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Reference series in phytochemistry, Год журнала: 2025, Номер unknown, С. 1 - 40
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Reference series in phytochemistry, Год журнала: 2025, Номер unknown, С. 1 - 31
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Cuadernos de Educación y Desarrollo, Год журнала: 2025, Номер 17(1), С. e7268 - e7268
Опубликована: Янв. 16, 2025
This study set out to evaluate how effective the unexplored macrofungi Langermannia bicolor is in providing a biomolecular repertoire capable of optimizing action antibacterials available on market. Extract and fractions (obtained by fractionation with acetone) L. were quantified for presence proteases hemagglutinin, composition carbohydrates, proteins, phenolic flavonoid compounds; then, they tested against multidrug-resistant gram-positive gram-negative strains combined conventional antibiotics from different classes. Fraction 2 (F2) stood its high proteolytic hemagglutinating capacities, could reduce therapeutic dosage all pathogens tested. The samples – especially showed promising results antibiotics, thus potentially mitigating escalation resistance bacteria. project first investigate medicinal properties bicolor, focusing major biomolecules, potential as an enhancer.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Reference series in phytochemistry, Год журнала: 2025, Номер unknown, С. 1 - 44
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 21 - 34
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0