Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

Antioxidants, Год журнала: 2024, Номер 13(4), С. 484 - 484

Опубликована: Апрель 18, 2024

The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation

Язык: Английский

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Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets

Cellular and Molecular Neurobiology, Год журнала: 2024, Номер 44(1)

Опубликована: Фев. 23, 2024

Ferroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related ferroptosis. The mechanisms ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide as well glutathione amino acid metabolism. What's more, the causal relationship between IS elucidated by several processes. disruption blood-brain barrier, release excitatory acids, inflammatory response after all lead disorder metabolism antioxidant system. Based on these statements, we reviewed reported effects compounds drugs treating modulating key molecules in Through detailed analysis roles molecules, have also more clearly demonstrated essential effect occurrence so provide new targets ideas for therapeutic IS.

Язык: Английский

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Current advances and future trends of hormesis in disease

npj Aging, Год журнала: 2024, Номер 10(1)

Опубликована: Май 15, 2024

Abstract Hormesis, an adaptive response, occurs when exposure to low doses of a stressor potentially induces stimulatory effect, while higher may inhibit it. This phenomenon is widely observed across various organisms and stressors, significantly advancing our understanding inspiring further exploration the beneficial effects toxins at both below beyond traditional thresholds. has profound implications for promoting biological regulation cellular level enhancing adaptability throughout biosphere. Therefore, conducting bibliometric analysis in this field crucial accurately analyzing summarizing its current research status. The results reveal steady increase number publications over years. United States emerges as leading country publication citation numbers, with journal Dose–Response publishing highest papers area. Calabrese E.J. prominent person significant contributions influence among authors. Through keyword co-occurrence trend analysis, hotspots are identified, primarily focusing on relationship between hormesis, oxidative stress, aging. Analysis highly cited references predicts that future trends center around hormesis stress different doses, well exploring mechanisms applications hormesis. In conclusion, review aims visually represent hormesis-related through methods, uncovering emerging patterns areas focus within field. It provides summary status forecasts research.

Язык: Английский

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Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12155 - 12155

Опубликована: Ноя. 12, 2024

The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease. Several bioactive nutrients, including medicinal herbs, flavonoids, bioavailable polyphenol-combined nanoparticles, as well probiotics, vitamin D omega-3 fatty acids, have been shown improve blood-brain barrier (BBB) dysfunction, endogenous neurosteroid homeostasis brain function. These can inhibit oxidative neuroinflammation, which are linked the pathogenesis of various neurological disorders. Interestingly, flavonoids exhibit dose-dependent effects, activating nuclear factor erythroid 2-related 2 (Nrf2) pathway at physiological/low dose (neurohormesis). This leads upregulation antioxidant phase II genes proteins such heme oxygenase-1 (HO-1) sirtuin-1 (Sirt1), activated by curcumin resveratrol, respectively. adaptive neuronal response mechanisms help protect against reactive oxygen species (ROS) neurotoxicity. Impaired Nrf2 hormone signaling exacerbate selective vulnerability neuroinflammatory conditions, contributing onset progression neurodegenerative psychiatric disorders, Alzheimer's disease, anxiety depression other due neurons stress. review focuses on targeting redox regulate BBB damage associated with altered GABAergic neurotransmission. By exploring underlying molecular using innovative technologies, we aim develop promising neuroprotective strategies personalized nutritional neuroregenerative therapies prevent or attenuate ultimately promoting health.

Язык: Английский

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REDOXOMICS IN AGEING AND NEURODEGENERATIVE DISORDERS: FROM BENCH TO CLINICS

Translational Medicine UniSa, Год журнала: 2024, Номер 25(2)

Опубликована: Янв. 19, 2024

Язык: Английский

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Investigating hormesis, aging, and neurodegeneration: From bench to clinics

Open Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 1, 2024

Abstract Mitochondria-derived reactive oxygen species production at a moderate physiological level plays fundamental role in the anti-aging signaling, due to their action as redox-active sensors for maintenance of optimal mitochondrial balance between intracellular energy status and hormetic nutrients. Iron regulatory protein dysregulation, systematically increased iron levels, dysfunction, consequent oxidative stress are recognized underlie pathogenesis multiple neurodegenerative diseases, such Parkinson’s disease Alzheimer’s disease. Central pathogenesis, Nrf2 signaling dysfunction occurs with disruption metabolic homeostasis. We highlight potential therapeutic importance nutritional polyphenols substantive regulators pathway. Here, we discuss common mechanisms targeting Nrf2/vitagene pathway, novel strategies minimize consequences neuroinflammation, generally associated cognitive demonstrate its key neuroprotective anti-neuroinflammatory properties, summarizing pharmacotherapeutic aspects relevant brain pathophysiology.

Язык: Английский

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Frankincense: A neuronutrient to approach Parkinson’s disease treatment

Open Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 1, 2024

Abstract Parkinson’s disease (PD), characterized by tremor, slowness of movement, stiffness, and poor balance, is due to a significant loss dopaminergic neurons in the substantia nigra pars compacta nerve terminals striatum with deficit dopamine. To date mechanisms sustaining PD pathogenesis are under investigation; however, solid body experimental evidence involves neuroinflammation, mitochondrial dysfunction, oxidative stress, apoptotic cell death as crucial factors operating PD. Nutrition known modulate neuroinflammatory processes implicated progression this neurodegenerative disorder. Consistent notion, Burseraceae family, which includes genera Boswellia Commiphora , attracting emerging interest treatment wide range pathological conditions, including neuroinflammation cognitive decline. Bioactive components present these species have been shown improve function protect from degeneration vitro animal, well clinical research. These effects mediated through anti-inflammatory, antiamyloidogenic, anti-apoptotic, antioxidative properties bioactive components. Although many studies exploited possible therapeutic approaches, data human lacking their neuroprotective potential makes them promising option for preventing treating major disorders.

Язык: Английский

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Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new horizon in brain tumor management

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 15, 2024

Brain cancer is regarded as one of the most life-threatening forms worldwide. Oxidative stress acts to derange normal brain homeostasis, thus involved in carcinogenesis brain. The Nrf2/Keap1/ARE pathway an important signaling cascade responsible for maintenance redox and regulation anti-inflammatory anticancer activities by multiple downstream pathways. Interestingly, Nrf2 plays a somewhat, contradictory role cancers, including cancer. has traditionally been tumor suppressor since its cytoprotective functions are considered be principle cellular defense mechanism against exogenous endogenous insults, such xenobiotics oxidative stress. However, hyperactivation supports survival well malignant cells, protecting them stress, therapeutic agents. Plants possess pool secondary metabolites with potential chemotherapeutic/chemopreventive actions. Modulation Nrf2/ARE Keap1-dependant manner, aid plant-derived exhibits promise management tumors. Current article highlights effects on tumors, regarding same.

Язык: Английский

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Sex differences in the BTBR idiopathic mouse model of autism spectrum disorders: Behavioural and redox-related hippocampal alterations

Neuropharmacology, Год журнала: 2024, Номер 260, С. 110134 - 110134

Опубликована: Авг. 30, 2024

Autism spectrum disorders (ASD) are highly heterogeneous neurodevelopmental diseases. Epidemiological data report that males have been diagnosed with autism more frequently than females. However, recent studies hypothesize females' low incidence might be underestimated due to standard clinical measures of ASD behavioural symptoms, mostly derived from males. Indeed, up now, mouse models focused mainly on males, considering the prevalence diagnosis in sex. Regarding aetiopathogenesis, it has recently reported oxidative stress implicated its onset and development, suggesting an association typical repetitive behaviours still need disentangled. Here, we investigated possible molecular sex-related differences by using BTBR model idiopathic ASD. To this aim, animals were exposed tests related different core symptoms comorbidities, i.e. stereotyped repertoire, social dysfunctions, hyperlocomotion risk-taking behaviours. Moreover, analyzed hippocampal levels pro-oxidant anti-oxidant enzymes, together biomarkers lipid peroxidation. Our results showed females did not display same patterns for as male counterpart. From a biomolecular point view, found increase accompanied deficient enzymatic response, only compared C57BL/6 mice, while no retrieved Overall, our study suggests there is urgent depict distinct symptomatology, identification sex-specific pharmacological targets.

Язык: Английский

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Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder

Nutrients, Год журнала: 2024, Номер 16(18), С. 3113 - 3113

Опубликована: Сен. 15, 2024

Background/Objectives: Attention deficit hyperactivity disorder (ADHD) is the most common childhood-onset neurodevelopmental disorder, characterized by difficulty maintaining attention, impulsivity, and hyperactivity. While cause of this still unclear, recent studies have stated that heredity important in development ADHD. This linked to a few comorbidities, including depression, criminal behavior, anxiety. Although genetic factors influence ADHD symptoms, there are also non-genetic factors, one which oxidative stress (OS), plays role pathogenesis symptoms review aims explore OS its connection antioxidant enzyme levels, as well gut–brain axis (GBA), focusing on diet particularly adults with comorbid conditions. Methods: The literature search included main available databases (e.g., Science Direct, PubMed, Google Scholar). Articles English language were taken into consideration our screening was conducted based several words such “ADHD”, “oxidative stress”, “diet”, “gut–brain axis”, “gut microbiota.” focused examining link between ADHD, axis, potential impact dietary interventions. Results: Oxidative critical manifestation symptoms. Studies shown individuals exhibit reduced levels key enzymes, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), diminished total status (TOS) compared healthy controls. Additionally, evidence close bidirectional interaction nervous system gut microbiota, mediated axis. relationship suggests interventions targeting health may related comorbidities. Conclusions: A better understanding these mechanisms could lead more targeted treatments, interventions, mitigate Further research required therapeutic modulating microbiota management

Язык: Английский

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