Neuroprotective Agents with Therapeutic Potential for COVID-19 DOI Creative Commons

César A. Zaa,

Clara Espitia, Karen Lizbeth Reyes-Barrera

и другие.

Biomolecules, Год журнала: 2023, Номер 13(11), С. 1585 - 1585

Опубликована: Окт. 27, 2023

COVID-19 patients can exhibit a wide range of clinical manifestations affecting various organs and systems. Neurological symptoms have been reported in patients, both during the acute phase illness cases long-term COVID. Moderate include ageusia, anosmia, altered mental status, cognitive impairment, more severe manifest as ischemic cerebrovascular disease encephalitis. In this narrative review, we delve into neurological associated with COVID-19, well underlying mechanisms contributing to them. These direct damage neurons, inflammation, oxidative stress, protein misfolding. We further investigate potential small molecules from natural products offer neuroprotection models neurodegenerative diseases. Through our analysis, discovered that flavonoids, alkaloids, terpenoids, other compounds neuroprotective effects by modulating signaling pathways known be impacted COVID-19. Some these also directly target SARS-CoV-2 viral replication. Therefore, origin show promise agents prevent or mitigate nervous system patients. Further research evaluation different stages are warranted explore their benefits.

Язык: Английский

Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China DOI Open Access
Liyan Yang, Zhonglei Wang

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 257, С. 115503 - 115503

Опубликована: Май 18, 2023

Язык: Английский

Процитировано

65

Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy DOI Creative Commons
Zhonglei Wang, Liyan Yang

Pharmacological Research, Год журнала: 2024, Номер 203, С. 107150 - 107150

Опубликована: Март 21, 2024

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.

Язык: Английский

Процитировано

19

Microalgal Carotenoids: Therapeutic Application and Latest Approaches to Enhance the Production DOI Creative Commons

Priyanka Sirohi,

Hariom Verma,

Sandeep Kumar Singh

и другие.

Current Issues in Molecular Biology, Год журнала: 2022, Номер 44(12), С. 6257 - 6279

Опубликована: Дек. 9, 2022

Microalgae are microscopic photosynthetic organisms frequently found in fresh and marine water ecosystems. Various microalgal species have been considered a reservoir of diverse health-value products, including vitamins, proteins, lipids, polysaccharides, broadly utilized as food for the treatment human ailments such cancer, cardiovascular diseases, allergies, immunodeficiency. Microalgae-derived carotenoids type accessory pigment that possess light-absorbing potential play significant role metabolic functions. To date, nearly thousand reported, but very less number microalgae used commercial production carotenoids. This review article briefly discussed origin their therapeutic application. In addition, we compiled optimization culture parameters to enhance carotenoid production. latest biotechnological approaches improve yields has also discussed.

Язык: Английский

Процитировано

54

Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase DOI Creative Commons
Zhonglei Wang, Liyan Yang,

Xian-qing Song

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Дек. 6, 2022

GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral bioavailability of GS‐441524 poses challenge to its anti-SARS-CoV-2 efficacy. Remdesivir, intravenously administered version (version 1.0) first FDA-approved agent for SARS-CoV-2 treatment. clinical trials have presented conflicting evidence on value remdesivir in COVID-19. Therefore, GS-441524 derivatives (VV116, ATV006, and GS-621763; 2.0, targeting highly conserved viral RdRp) could be considered as game-changers treating COVID-19 because administration has potential maximize benefits, including decreased duration reduced post-acute sequelae infection, well limited side effects such hepatic accumulation. This review summarizes current research related provides important insights into factors underlying controversial observations regarding efficacy remdesivir; overall, it offers effective launching pad developing GS-441524.

Язык: Английский

Процитировано

49

An Overview of Potential Natural Photosensitizers in Cancer Photodynamic Therapy DOI Creative Commons
Bushra Aziz,

Iffat Aziz,

Ahmat Khurshid

и другие.

Biomedicines, Год журнала: 2023, Номер 11(1), С. 224 - 224

Опубликована: Янв. 16, 2023

Cancer is one of the main causes death worldwide. There are several different types cancer recognized thus far, which can be treated by approaches including surgery, radiotherapy, chemotherapy or a combination thereof. However, these have certain drawbacks and limitations. Photodynamic therapy (PDT) regarded as an alternative noninvasive approach for treatment based on generation toxic oxygen (known reactive species (ROS)) at site. PDT requires photoactivation photosensitizer (PS) specific wavelength (λ) light in vicinity molecular (singlet oxygen). The cell mechanisms adopted upon PS necrosis, apoptosis stimulation immune system. Over past few decades, use natural compounds photoactive agent selective eradication neoplastic lesions has attracted researchers' attention. Many reviews focused mode action photonanomedicine PDT, while limited attention been paid to phytocompounds. Photoactivation ever-present nature also found plant compounds. availability various laser setups play vital role discovery phytocompounds that used PS. Exploring their properties could reveal novel future pharmaceutical research. In this review, we highlight current research regarding phytocompound classes (furanocoumarins, alkaloids, poly-acetylenes thiophenes, curcumins, flavonoids, anthraquinones, extracts) potential encourage researchers focus studies agents potent enhance efficiency PDT.

Язык: Английский

Процитировано

44

Serial viral load analysis by DDPCR to evaluate FNC efficacy and safety in the treatment of mild cases of COVID-19 DOI Creative Commons
Renato Martins da Silva,

Paula Gebe Abreu Cabral,

Sávio Bastos de Souza

и другие.

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Март 14, 2023

Introduction The SARS-CoV-2 outbreak has threatened the human population globally as numbers of reinfection cases even after large-scale vaccination. Trials have been carried out to find drugs effective in fighting disease, COVID-19 is being considered a treatable disease only we antivirals. A clinical candidate originally developed for HIV treatment, AZVUDINE (FNC), promising drug treatment COVID-19. Methods To predict outcome COVID-19, examined course viral load, every 48 h, by RT-PCR, and severity using an antiviral drug, FNC, with 281 participants. randomized trial was performed evaluate efficacy FNC added standard compared placebo group patients mild RT-qPCR ddPCR were applied estimate load samples from patients. Also, improvement evaluated well liver kidney function. Results discussion Notably, may shorten time nucleic acid negative conversion (NANC) versus group. In addition, reducing these present results showed that accelerate elimination virus could reduce save lot medical resources, making it strong outpatient home Clinical registration https://clinicaltrials.gov/ct2/show/NCT05033145 , identifier NCT05033145.

Язык: Английский

Процитировано

33

The Therapeutic Potential of Natural Dietary Flavonoids against SARS-CoV-2 Infection DOI Open Access
Zhonglei Wang, Liyan Yang

Nutrients, Год журнала: 2023, Номер 15(15), С. 3443 - 3443

Опубликована: Авг. 3, 2023

The exploration of non-toxic and cost-effective dietary components, such as epigallocatechin 3-gallate myricetin, for health improvement disease treatment has recently attracted substantial research attention. recent COVID-19 pandemic provided a unique opportunity the investigation identification components capable treating viral infections, well gathering evidence needed to address major challenges presented by public emergencies. Dietary hold great potential starting point further drug development prevention SARS-CoV-2 infection owing their good safety, broad-spectrum antiviral activities, multi-organ protective capacity. Here, we review current knowledge characteristics-chemical composition, bioactive properties, putative mechanisms action-of natural flavonoids with targeting its variants. Notably, present promising strategies (combination therapy, lead optimization, delivery) overcome inherent deficiencies flavonoids, limited bioavailability poor stability.

Язык: Английский

Процитировано

26

The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target DOI Creative Commons
Teresa Santos-Mendoza

Viruses, Год журнала: 2023, Номер 15(4), С. 1000 - 1000

Опубликована: Апрель 19, 2023

The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect human population against severe forms of COVID-19. However, some variants concern (VOCs) emerged evade protective effect vaccine-induced antibodies. Therefore, efficient and specific antiviral treatments to control are indispensable. To date, two drugs approved for mild treatment; nevertheless, more drugs, preferably broad-spectrum ready-to-use therapeutic agents new pandemics, needed. Here, I discuss PDZ-dependent protein-protein interactions viral E protein with host proteins as attractive alternatives development antivirals coronavirus.

Язык: Английский

Процитировано

18

Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic DOI Creative Commons
Yedi Herdiana

Heliyon, Год журнала: 2025, Номер 11(4), С. e42739 - e42739

Опубликована: Фев. 1, 2025

This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.

Язык: Английский

Процитировано

1

Effectiveness, Tolerability and Prescribing Choice of Antiviral Molecules Molnupiravir, Remdesivir and Nirmatrelvir/r: A Real-World Comparison in the First Ten Months of Use DOI Creative Commons
Cosmo Del Borgo, Silvio Garattini,

Carolina Bortignon

и другие.

Viruses, Год журнала: 2023, Номер 15(4), С. 1025 - 1025

Опубликована: Апрель 21, 2023

In 2022, three antiviral drugs—molnupiravir, remdesivir and nirmatrelvir/ritonavir—were introduced for treatment of mild-to-moderate COVID-19 in high-risk patients. The aim this study is the evaluation their effectiveness tolerability a real-life setting. A single-center observational was set up, with involvement 1118 patients, complete follow-up data, treated between 5th January 3rd October 2022 at Santa Maria Goretti’s hospital Latina, Central Italy. univariable multivariable analysis were performed on clinical demographic data composite outcome, persistence symptoms 30 days time to negativization, respectively. antivirals showed similar containing progression infection severe good absence serious adverse effects. Persistence after more common females than males less patients molnupiravir nirmatrelvir/r. availability different molecules strong tool and, if correctly prescribed, they can have significant role changing natural history frail persons, which vaccination could be not sufficient prevention COVID-19.

Язык: Английский

Процитировано

16