Frontiers in Chemistry,
Journal Year:
2022,
Volume and Issue:
10
Published: Dec. 6, 2022
The
economical
and
societal
impact
of
COVID-19
has
made
the
development
vaccines
drugs
to
combat
SARS-CoV-2
infection
a
priority.
While
spike
protein
been
widely
explored
as
drug
target,
helicase
(nsp13)
does
not
have
any
approved
medication.
shares
99.8%
similarity
with
its
SARS-CoV-1
homolog
was
shown
be
essential
for
viral
replication.
This
review
summarizes
builds
on
existing
research
inhibitors
helicases.
Our
analysis
toxicity
specificity
these
compounds,
set
road
going
forward
repurposing
new
inhibitors.
Current Issues in Molecular Biology,
Journal Year:
2022,
Volume and Issue:
44(12), P. 6257 - 6279
Published: Dec. 9, 2022
Microalgae
are
microscopic
photosynthetic
organisms
frequently
found
in
fresh
and
marine
water
ecosystems.
Various
microalgal
species
have
been
considered
a
reservoir
of
diverse
health-value
products,
including
vitamins,
proteins,
lipids,
polysaccharides,
broadly
utilized
as
food
for
the
treatment
human
ailments
such
cancer,
cardiovascular
diseases,
allergies,
immunodeficiency.
Microalgae-derived
carotenoids
type
accessory
pigment
that
possess
light-absorbing
potential
play
significant
role
metabolic
functions.
To
date,
nearly
thousand
reported,
but
very
less
number
microalgae
used
commercial
production
carotenoids.
This
review
article
briefly
discussed
origin
their
therapeutic
application.
In
addition,
we
compiled
optimization
culture
parameters
to
enhance
carotenoid
production.
latest
biotechnological
approaches
improve
yields
has
also
discussed.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 6, 2022
GS-441524,
an
RNA‐dependent
RNA
polymerase
(RdRp)
inhibitor,
is
a
1′-CN-substituted
adenine
C-nucleoside
analog
with
broad-spectrum
antiviral
activity.
However,
the
low
oral
bioavailability
of
GS‐441524
poses
challenge
to
its
anti-SARS-CoV-2
efficacy.
Remdesivir,
intravenously
administered
version
(version
1.0)
first
FDA-approved
agent
for
SARS-CoV-2
treatment.
clinical
trials
have
presented
conflicting
evidence
on
value
remdesivir
in
COVID-19.
Therefore,
GS-441524
derivatives
(VV116,
ATV006,
and
GS-621763;
2.0,
targeting
highly
conserved
viral
RdRp)
could
be
considered
as
game-changers
treating
COVID-19
because
administration
has
potential
maximize
benefits,
including
decreased
duration
reduced
post-acute
sequelae
infection,
well
limited
side
effects
such
hepatic
accumulation.
This
review
summarizes
current
research
related
provides
important
insights
into
factors
underlying
controversial
observations
regarding
efficacy
remdesivir;
overall,
it
offers
effective
launching
pad
developing
GS-441524.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(1), P. 224 - 224
Published: Jan. 16, 2023
Cancer
is
one
of
the
main
causes
death
worldwide.
There
are
several
different
types
cancer
recognized
thus
far,
which
can
be
treated
by
approaches
including
surgery,
radiotherapy,
chemotherapy
or
a
combination
thereof.
However,
these
have
certain
drawbacks
and
limitations.
Photodynamic
therapy
(PDT)
regarded
as
an
alternative
noninvasive
approach
for
treatment
based
on
generation
toxic
oxygen
(known
reactive
species
(ROS))
at
site.
PDT
requires
photoactivation
photosensitizer
(PS)
specific
wavelength
(λ)
light
in
vicinity
molecular
(singlet
oxygen).
The
cell
mechanisms
adopted
upon
PS
necrosis,
apoptosis
stimulation
immune
system.
Over
past
few
decades,
use
natural
compounds
photoactive
agent
selective
eradication
neoplastic
lesions
has
attracted
researchers'
attention.
Many
reviews
focused
mode
action
photonanomedicine
PDT,
while
limited
attention
been
paid
to
phytocompounds.
Photoactivation
ever-present
nature
also
found
plant
compounds.
availability
various
laser
setups
play
vital
role
discovery
phytocompounds
that
used
PS.
Exploring
their
properties
could
reveal
novel
future
pharmaceutical
research.
In
this
review,
we
highlight
current
research
regarding
phytocompound
classes
(furanocoumarins,
alkaloids,
poly-acetylenes
thiophenes,
curcumins,
flavonoids,
anthraquinones,
extracts)
potential
encourage
researchers
focus
studies
agents
potent
enhance
efficiency
PDT.
Frontiers in Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: March 14, 2023
Introduction
The
SARS-CoV-2
outbreak
has
threatened
the
human
population
globally
as
numbers
of
reinfection
cases
even
after
large-scale
vaccination.
Trials
have
been
carried
out
to
find
drugs
effective
in
fighting
disease,
COVID-19
is
being
considered
a
treatable
disease
only
we
antivirals.
A
clinical
candidate
originally
developed
for
HIV
treatment,
AZVUDINE
(FNC),
promising
drug
treatment
COVID-19.
Methods
To
predict
outcome
COVID-19,
examined
course
viral
load,
every
48
h,
by
RT-PCR,
and
severity
using
an
antiviral
drug,
FNC,
with
281
participants.
randomized
trial
was
performed
evaluate
efficacy
FNC
added
standard
compared
placebo
group
patients
mild
RT-qPCR
ddPCR
were
applied
estimate
load
samples
from
patients.
Also,
improvement
evaluated
well
liver
kidney
function.
Results
discussion
Notably,
may
shorten
time
nucleic
acid
negative
conversion
(NANC)
versus
group.
In
addition,
reducing
these
present
results
showed
that
accelerate
elimination
virus
could
reduce
save
lot
medical
resources,
making
it
strong
outpatient
home
Clinical
registration
https://clinicaltrials.gov/ct2/show/NCT05033145
,
identifier
NCT05033145.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3443 - 3443
Published: Aug. 3, 2023
The
exploration
of
non-toxic
and
cost-effective
dietary
components,
such
as
epigallocatechin
3-gallate
myricetin,
for
health
improvement
disease
treatment
has
recently
attracted
substantial
research
attention.
recent
COVID-19
pandemic
provided
a
unique
opportunity
the
investigation
identification
components
capable
treating
viral
infections,
well
gathering
evidence
needed
to
address
major
challenges
presented
by
public
emergencies.
Dietary
hold
great
potential
starting
point
further
drug
development
prevention
SARS-CoV-2
infection
owing
their
good
safety,
broad-spectrum
antiviral
activities,
multi-organ
protective
capacity.
Here,
we
review
current
knowledge
characteristics-chemical
composition,
bioactive
properties,
putative
mechanisms
action-of
natural
flavonoids
with
targeting
its
variants.
Notably,
present
promising
strategies
(combination
therapy,
lead
optimization,
delivery)
overcome
inherent
deficiencies
flavonoids,
limited
bioavailability
poor
stability.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
203, P. 107150 - 107150
Published: March 21, 2024
Cancer,
with
its
diversity,
heterogeneity,
and
complexity,
is
a
significant
contributor
to
global
morbidity,
disability,
mortality,
highlighting
the
necessity
for
transformative
treatment
approaches.
Photodynamic
therapy
(PDT)
has
aroused
continuous
interest
as
viable
alternative
conventional
cancer
treatments
that
encounter
drug
resistance.
Nanotechnology
brought
new
advances
in
medicine
shown
great
potential
delivery
treatment.
For
precise
efficient
therapeutic
utilization
of
such
tumor
approach
high
spatiotemporal
selectivity
minimal
invasiveness,
carrier-free
noncovalent
nanoparticles
(NPs)
based
on
chemo-photodynamic
combination
essential.
Utilizing
natural
products
foundation
nanodrug
development
offers
unparalleled
advantages,
including
exceptional
pharmacological
activity,
easy
functionalization/modification,
well
biocompatibility.
The
natural-product-based,
carrier-free,
NPs
revealed
excellent
synergistic
anticancer
activity
comparison
free
photosensitizers
bioactive
products,
representing
an
favorable
avenue
improve
efficacy.
Herein,
comprehensive
summary
current
strategies
representative
application
examples
past
decade
(such
paclitaxel,
10-hydroxycamptothecin,
doxorubicin,
etoposide,
combretastatin
A4,
epigallocatechin
gallate,
curcumin)
therapy.
We
highlight
insightful
design
synthesis
smart
aim
enhance
PDT
Meanwhile,
we
discuss
future
challenges
opportunities
associated
these
provide
enlightenment,
spur
innovative
ideas,
facilitate
PDT-mediated
clinical
transformation.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42739 - e42739
Published: Feb. 1, 2025
This
review
explores
the
synergistic
potential
of
natural
products
and
nanotechnology
for
viral
infections,
highlighting
key
antiviral,
immunomodulatory,
antioxidant
properties
to
combat
pandemics
caused
by
highly
infectious
viruses.
These
often
result
in
severe
public
health
crises,
particularly
affecting
vulnerable
populations
due
respiratory
complications
increased
mortality
rates.
A
cytokine
storm
is
initiated
when
an
overload
pro-inflammatory
cytokines
chemokines
released,
leading
a
systemic
inflammatory
response.
Viral
mutations
limited
availability
effective
drugs,
vaccines,
therapies
contribute
continuous
transmission
virus.
The
coronavirus
disease-19
(COVID-19)
pandemic
has
sparked
renewed
interest
product-derived
antivirals.
efficacy
traditional
medicines
against
infections
examined.
Their
anti-inflammatory,
are
highlighted.
discusses
how
enhances
herbal
combating
infections.
Viruses,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1000 - 1000
Published: April 19, 2023
The
COVID-19
pandemic
caused
by
the
SARS-CoV-2
virus
is
still
a
global
health
concern.
Several
spike
(S)
protein-based
vaccines
have
been
developed
that
efficiently
protect
human
population
against
severe
forms
of
COVID-19.
However,
some
variants
concern
(VOCs)
emerged
evade
protective
effect
vaccine-induced
antibodies.
Therefore,
efficient
and
specific
antiviral
treatments
to
control
are
indispensable.
To
date,
two
drugs
approved
for
mild
treatment;
nevertheless,
more
drugs,
preferably
broad-spectrum
ready-to-use
therapeutic
agents
new
pandemics,
needed.
Here,
I
discuss
PDZ-dependent
protein-protein
interactions
viral
E
protein
with
host
proteins
as
attractive
alternatives
development
antivirals
coronavirus.
Viruses,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1025 - 1025
Published: April 21, 2023
In
2022,
three
antiviral
drugs—molnupiravir,
remdesivir
and
nirmatrelvir/ritonavir—were
introduced
for
treatment
of
mild-to-moderate
COVID-19
in
high-risk
patients.
The
aim
this
study
is
the
evaluation
their
effectiveness
tolerability
a
real-life
setting.
A
single-center
observational
was
set
up,
with
involvement
1118
patients,
complete
follow-up
data,
treated
between
5th
January
3rd
October
2022
at
Santa
Maria
Goretti’s
hospital
Latina,
Central
Italy.
univariable
multivariable
analysis
were
performed
on
clinical
demographic
data
composite
outcome,
persistence
symptoms
30
days
time
to
negativization,
respectively.
antivirals
showed
similar
containing
progression
infection
severe
good
absence
serious
adverse
effects.
Persistence
after
more
common
females
than
males
less
patients
molnupiravir
nirmatrelvir/r.
availability
different
molecules
strong
tool
and,
if
correctly
prescribed,
they
can
have
significant
role
changing
natural
history
frail
persons,
which
vaccination
could
be
not
sufficient
prevention
COVID-19.
