International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11630 - 11630
Опубликована: Окт. 29, 2024
In
recent
years,
natural
polymers
have
attracted
great
interest
for
the
development
of
release
systems
vaccine
formulations
and
drug
delivery.
Zein,
a
hydrophobic
proline-rich
protein
mixture
obtained
from
maize,
is
one
most
widely
used
polymers,
very
promising
applications
in
tissue
engineering
parenteral
delivery
bioactive
agents.
Still,
we
limited
understanding
interaction
between
zein
particles
human
immune
system,
particular
innate
immunity/inflammation,
which
first
line
defense
our
body.
Assessing
safety
nanoparticles
central
importance
ensuring
that
nano-formulations
medical
use
do
not
cause
adverse
effects
on
health.
Here,
evaluated
capacity
to
induce/modulate
innate/inflammatory
response,
memory,
macrophage
polarization
by
using
reliable
vitro
based
primary
monocytes
monocyte-derived
macrophages.
We
observed
influence
any
these
aspects
immune/inflammatory
suggesting
its
potential
efficiency
as
nanocarrier
or
antigen
OpenNano,
Год журнала:
2023,
Номер
13, С. 100170 - 100170
Опубликована: Июнь 30, 2023
Thymol
and
carvacrol
are
aromatic
compounds
derived
from
plants
that
exhibit
considerable
broad-spectrum
antimicrobial
effects.
They
have
also
shown
extensive
biological
effects,
including
antispasmodic,
anti-inflammatory,
anti-carcinogenic.
Carvacrol
thymol
pleasant
smells,
tastes,
potent
antioxidant
Therefore,
along
with
their
favorable
toxicity,
make
an
option
as
additive
to
inhibit
microbial
spoilage
of
foods
agents
against
antibiotic-resistant
bacteria.
However,
volatility,
low
stability,
high
hydrophobicity
some
the
limitations
thymol,
which
limit
application.
To
increase
efficacy
carvacrol,
especially
properties,
using
a
drug
delivery
system
might
be
practical
option.
Encapsulation
essential
oils
into
appropriated
nanocarriers
may
decrease
potential
limitations.
thymol-encapsulated
nanomaterials
been
more
solubility
increased
antibacterial
Here,
we
provide
brief
review
effects
nanoformulation
give
prospect
on
applications
for
future
studies
natural
food
additives.
Nanomaterials,
Год журнала:
2024,
Номер
14(5), С. 414 - 414
Опубликована: Фев. 23, 2024
Nanomaterials,
due
to
their
unique
structural
and
functional
features,
are
widely
investigated
for
potential
applications
in
a
wide
range
of
industrial
sectors.
In
this
context,
protein-based
nanoparticles,
given
proteins’
abundance,
non-toxicity,
stability,
offer
promising
sustainable
methodology
encapsulation
protection,
can
be
used
engineered
nanocarriers
that
capable
releasing
active
compounds
on
demand.
Zein
is
plant-based
protein
extracted
from
corn,
it
biocompatible,
biodegradable,
amphiphilic.
Several
approaches
technologies
currently
involved
zein-based
nanoparticle
preparation,
such
as
antisolvent
precipitation,
spray
drying,
supercritical
processes,
coacervation,
emulsion
procedures.
Thanks
peculiar
characteristics,
nanoparticles
targeted
application
fields
drug
delivery,
bioimaging,
or
soft
tissue
engineering,
reported
by
others.
The
main
goal
review
investigate
the
use
different
advanced
including
food/food
packaging,
cosmetics,
agriculture,
which
attracting
researchers’
efforts,
exploit
future
development
zein
NPs
field
cultural
heritage,
still
relatively
unexplored.
Moreover,
presented
overview
focuses
several
preparation
methods
(i.e.,
spry
drying),
correlating
analyzed
methodologies
NPs’
properties
capability
act
carriers
bioactive
compounds,
both
preserve
activity
tune
release
specific
working
conditions.
Sustainable
plant-derived
biopolymers
cellulose
nanocrystals
(CNC)
and
Zein
protein
were
used
to
deliver
plasmid
DNA
with
a
reporter
GFP
gene
(pDNA)
plant
cells.
CNC
modified
the
cationic
agent
2,3-epoxypropyltrimethylammonium
chloride
(EPTMAC)
electrostatically
bind
negatively
charged
pDNA.
Established
pDNA-CNC
pDNA-Zeins
conjugates
delivered
tobacco
cells
by
leaf
injection
vacuum
infiltration
of
leaves
seedlings.
Both
methods
effectively
provided
transient
expression
in
exposed
that
was
visualized
confocal
microscopy
confirmed
qRT-PCR
(GFP
expression)
Western
blot
expression).
Our
findings
support
idea
nanopolymers
derived
from
agricultural
waste
residues
can
successfully
be
advance
transformation
editing.
Delivering
genetic
material
using
biocompatible,
plant-based
large-scale
tissues
reduces
existing
limitations
increases
speed
process.
Ultrasonics Sonochemistry,
Год журнала:
2023,
Номер
99, С. 106549 - 106549
Опубликована: Авг. 6, 2023
This
study
firstly
used
sugarcane
leaf
polyphenols
(SGLp)
to
modify
zein
form
covalent
nanoparticles
(SGLpZ)
and
SGLpZ
as
an
emulsifier
stabilize
pickering
emulsions
(SZP)
via
ultrasonic
method.
The
results
showed
that
the
addition
of
SGLp
could
alter
physicochemical
properties
zein,
including
improving
increasing
hydrophilicity
antioxidant
(three
basic
activities
test
in
vitro).
be
able
a
dense
film
on
surface
which
inhibited
lipid
oxidation
concentration
increased
at
4
℃
for
20
days,
thus
stabilizing
(SZP).
Further
assessment
storage
stability
stabilized
by
was
evaluated
measuring
free
fatty
acids
(FFA)
release
vitro
gastrointestinal
digestion.
FFA
SZP
decreased
from
20.61
±
0.10%
16.14
0.69%.
In
addition,
gave
yellow
color,
inspired
food
industry
make
yellow-colored
functional
foods.
Finally,
safety
initially
assessed
in-vitro
hemocompatibility
cytotoxicity
(MTT)
assays.
conclusion,
our
fingdings
were
beneficial
further
design
development
fields
enabled
new
type
protein-plant
emulsions.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Natural
bioactive
compounds
from
plants
exhibit
substantial
pharmacological
potency
and
therapeutic
value.
However,
the
development
of
most
plant
is
hindered
by
low
solubility
instability.
Conventional
pharmaceutical
forms,
such
as
tablets
capsules,
only
partially
overcome
these
limitations,
restricting
their
efficacy.
With
recent
nanotechnology,
nanocarriers
can
enhance
bioavailability,
stability,
precise
intracellular
transport
compounds.
Researchers
are
increasingly
integrating
nanocarrier‐based
drug
delivery
systems
(NDDS)
into
natural
with
significant
success.
Moreover,
products
benefit
nanotechnological
enhancement
contribute
to
innovation
optimization
via
self‐assembly,
grafting
modifications,
biomimetic
designs.
This
review
aims
elucidate
collaborative
reciprocal
advancement
achieved
botanical
products,
compounds,
polysaccharides,
proteins,
extracellular
vesicles.
underscores
salient
challenges
in
nanomedicine,
encompassing
long‐term
safety
evaluations
nanomedicine
formulations,
targeting
mechanisms,
biodistribution
complexities,
hurdles
clinical
translation.
Further,
this
study
provides
new
perspectives
leverage
nanotechnology
promoting
for
nanomedical
applications
guiding
progression
NDDS
toward
enhanced
efficiency,
precision,
safety.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanotechnology
Biology
Nanoscale
Systems
