Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 27, 2025
The
development
of
innovative
antitumor
formulations
that
are
able
to
increase
the
mortality
cancer
cells
while
decreasing
efficacious
pharmacological
dosage
is
a
fundamental
goal
modern
oncological
research.
In
this
study
paclitaxel
(PTX)-nanomedicine
was
tested
on
two
lines
human
high-grade
serous
ovarian
carcinoma
(hHGS-OC).
Zein,
vegetal
protein,
employed
obtain
nanoparticles
containing
lipophilic
compound
(NanoPTX)
characterized
by
mean
diameter
160
nm,
narrow
size
distribution,
negative
zeta
potential
and
prolonged
release
drug
over
time.
NanoPTX
HEY
COV362
demonstrating
an
apoptosis,
particularly
papillary
cystadenocarcinoma
(55.2%
p
value
0.037
for
vs
70.25%,
0.08
PTX)
with
respect
free
form
drug.
fluorescent
nanosystems
were
significant
cell
uptake
after
few
hours
incubation
they
promoted
reduction
in
intracellular
reactive
oxygen
species.
results
need
be
validated
different
hHGS-OC
real
efficacy
proposed
nanomedicine
needs
investigated
using
vivo
models
carcinoma.
OpenNano,
Journal Year:
2023,
Volume and Issue:
13, P. 100170 - 100170
Published: June 30, 2023
Thymol
and
carvacrol
are
aromatic
compounds
derived
from
plants
that
exhibit
considerable
broad-spectrum
antimicrobial
effects.
They
have
also
shown
extensive
biological
effects,
including
antispasmodic,
anti-inflammatory,
anti-carcinogenic.
Carvacrol
thymol
pleasant
smells,
tastes,
potent
antioxidant
Therefore,
along
with
their
favorable
toxicity,
make
an
option
as
additive
to
inhibit
microbial
spoilage
of
foods
agents
against
antibiotic-resistant
bacteria.
However,
volatility,
low
stability,
high
hydrophobicity
some
the
limitations
thymol,
which
limit
application.
To
increase
efficacy
carvacrol,
especially
properties,
using
a
drug
delivery
system
might
be
practical
option.
Encapsulation
essential
oils
into
appropriated
nanocarriers
may
decrease
potential
limitations.
thymol-encapsulated
nanomaterials
been
more
solubility
increased
antibacterial
Here,
we
provide
brief
review
effects
nanoformulation
give
prospect
on
applications
for
future
studies
natural
food
additives.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(5), P. 414 - 414
Published: Feb. 23, 2024
Nanomaterials,
due
to
their
unique
structural
and
functional
features,
are
widely
investigated
for
potential
applications
in
a
wide
range
of
industrial
sectors.
In
this
context,
protein-based
nanoparticles,
given
proteins’
abundance,
non-toxicity,
stability,
offer
promising
sustainable
methodology
encapsulation
protection,
can
be
used
engineered
nanocarriers
that
capable
releasing
active
compounds
on
demand.
Zein
is
plant-based
protein
extracted
from
corn,
it
biocompatible,
biodegradable,
amphiphilic.
Several
approaches
technologies
currently
involved
zein-based
nanoparticle
preparation,
such
as
antisolvent
precipitation,
spray
drying,
supercritical
processes,
coacervation,
emulsion
procedures.
Thanks
peculiar
characteristics,
nanoparticles
targeted
application
fields
drug
delivery,
bioimaging,
or
soft
tissue
engineering,
reported
by
others.
The
main
goal
review
investigate
the
use
different
advanced
including
food/food
packaging,
cosmetics,
agriculture,
which
attracting
researchers’
efforts,
exploit
future
development
zein
NPs
field
cultural
heritage,
still
relatively
unexplored.
Moreover,
presented
overview
focuses
several
preparation
methods
(i.e.,
spry
drying),
correlating
analyzed
methodologies
NPs’
properties
capability
act
carriers
bioactive
compounds,
both
preserve
activity
tune
release
specific
working
conditions.
JCIS Open,
Journal Year:
2024,
Volume and Issue:
15, P. 100120 - 100120
Published: July 6, 2024
Understanding
the
release
behaviour
of
nanodrugs
is
a
crucial
step
to
better
assess
and
control
therapeutic
outcomes
unfavourable
side
effects.
Herein,
we
report
systematic
study
comparing
kinetics
thermodynamics
paclitaxel
(PTX)
from
supramolecularly
assembled
sub-micron
particles
based
on
natural
macromolecules
such
as
zein,
whey,
casein,
bovine
serum
albumin
(BSA)
conventional
stabilizers
pluronic
F-127
(poloxamer
407),
β-cyclodextrin
(β-CD)
gain
insights
into
role
carrier
chemistry.
For
this
purpose,
nanomedicines
with
statistically
indifferent
sizes
—in
range
191.0
±
0.8
nm
243.3
11.6
(zein)
were
prepared
(p
>
0.05).
The
zeta
potential
values
ranged
−3.2
1.1
mV
(pluronic
F-127)
−17.2
1.8
(whey)
in
phosphate
buffered
saline.
type
nanocarrier
significantly
influenced
long-term
steady-state
plateau
release,
resulting
cumulative
70.3
2.0
%
PTX
casein
(the
highest)
46.8
4.7
zein
lowest).
Time-resolved
data
analysed
various
kinetical
models,
encompassing
zero-order,
first-order,
Higuchi,
Peppas-Sahlin,
Korsmeyer-Peppas
kinetics.
analysis
revealed
that
model
best
captured
data.
these
nanomedicines,
half-life
encapsulated
drugs
was
found
be
106.4
31.3
h
(zein),
1.2
(whey),
10.7
F-127),
6.4
0.9
(casein),
10.8
3.2
(β-CD),
4.0
1.0
(BSA).
TEM
characterization
differences
macromolecular
arrangement
active
ingredient
within
nanocarriers,
addition
structural
among
encapsulating
agents.
These
manifested
variations
internal
nanostructures,
leading
creation
distinct
microenvironments
could
either
facilitate
or
impede
movement
molecules
through
encapsulant
matrices.
In
clinical
settings,
fine
details
design
are
important:
by
choosing
most
appropriate
(or
their
mixtures),
clinicians
can
fine-tune
drug
administration
obtain
intended
window
while
mitigating
risk
negative
reactions.
Ultrasonics Sonochemistry,
Journal Year:
2023,
Volume and Issue:
99, P. 106549 - 106549
Published: Aug. 6, 2023
This
study
firstly
used
sugarcane
leaf
polyphenols
(SGLp)
to
modify
zein
form
covalent
nanoparticles
(SGLpZ)
and
SGLpZ
as
an
emulsifier
stabilize
pickering
emulsions
(SZP)
via
ultrasonic
method.
The
results
showed
that
the
addition
of
SGLp
could
alter
physicochemical
properties
zein,
including
improving
increasing
hydrophilicity
antioxidant
(three
basic
activities
test
in
vitro).
be
able
a
dense
film
on
surface
which
inhibited
lipid
oxidation
concentration
increased
at
4
℃
for
20
days,
thus
stabilizing
(SZP).
Further
assessment
storage
stability
stabilized
by
was
evaluated
measuring
free
fatty
acids
(FFA)
release
vitro
gastrointestinal
digestion.
FFA
SZP
decreased
from
20.61
±
0.10%
16.14
0.69%.
In
addition,
gave
yellow
color,
inspired
food
industry
make
yellow-colored
functional
foods.
Finally,
safety
initially
assessed
in-vitro
hemocompatibility
cytotoxicity
(MTT)
assays.
conclusion,
our
fingdings
were
beneficial
further
design
development
fields
enabled
new
type
protein-plant
emulsions.
International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
7, P. 100238 - 100238
Published: March 11, 2024
The
clinical
advancement
of
protein-based
nanomedicine
has
revolutionized
medical
professionals'
perspectives
on
cancer
therapy.
Protein-based
nanoparticles
have
been
exploited
as
attractive
vehicles
for
due
to
their
unique
properties
derived
from
naturally
biomacromolecules
with
superior
biocompatibility
and
pharmaceutical
features.
Furthermore,
the
successful
translation
Abraxane™
(paclitaxel-based
albumin
nanoparticles)
into
application
opened
a
new
avenue
nanomedicine.
In
this
mini-review
article,
we
demonstrate
rational
design
recent
progress
along
applications
in
diagnosis
therapy
literature.
current
challenges
hurdles
that
hinder
are
highlighted.
Finally,
future
translating
clinic
identified.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(3)
Published: May 1, 2024
Abstract
Natural
bioactive
compounds
from
plants
exhibit
substantial
pharmacological
potency
and
therapeutic
value.
However,
the
development
of
most
plant
is
hindered
by
low
solubility
instability.
Conventional
pharmaceutical
forms,
such
as
tablets
capsules,
only
partially
overcome
these
limitations,
restricting
their
efficacy.
With
recent
nanotechnology,
nanocarriers
can
enhance
bioavailability,
stability,
precise
intracellular
transport
compounds.
Researchers
are
increasingly
integrating
nanocarrier‐based
drug
delivery
systems
(NDDS)
into
natural
with
significant
success.
Moreover,
products
benefit
nanotechnological
enhancement
contribute
to
innovation
optimization
via
self‐assembly,
grafting
modifications,
biomimetic
designs.
This
review
aims
elucidate
collaborative
reciprocal
advancement
achieved
botanical
products,
compounds,
polysaccharides,
proteins,
extracellular
vesicles.
underscores
salient
challenges
in
nanomedicine,
encompassing
long‐term
safety
evaluations
nanomedicine
formulations,
targeting
mechanisms,
biodistribution
complexities,
hurdles
clinical
translation.
Further,
this
study
provides
new
perspectives
leverage
nanotechnology
promoting
for
nanomedical
applications
guiding
progression
NDDS
toward
enhanced
efficiency,
precision,
safety.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanotechnology
Biology
Nanoscale
Systems
