Опубликована: Янв. 1, 2024
Язык: Английский
Nano TransMed, Год журнала: 2023, Номер 2(2-3), С. 100004 - 100004
Опубликована: Сен. 1, 2023
Extracellular vesicles (EVs), which are natural nanocarriers characterized by a phospholipid bilayer structure, released living cells. They play crucial role in the intercellular transport of proteins, nucleic acids, lipids, and metabolites, facilitating substance delivery information exchange between In light recent numerous studies, EVs has been found to transcend their basic as mere vehicle. Instead, they demonstrate an impressive array biological activities, displaying preventive therapeutic potential mitigating various pathological processes encompassing cancer, neoplastic proliferation, infectious diseases, oxidative trauma. Particularly, derived from edible plants (EPDEVs) have emphasized for extensive range physiological regulatory functions animals humans, with targeted drug through oral administration. Leveraging these advantages, EPDEVs expected excellent competitiveness clinical applications or healthcare products. This review provides brief overview biogenesis, composition EPDEVs, summarizes mechanisms. It also analyzes methods isolating purifying plant-EVs, assessing advantages disadvantages; discusses latest advancements biomedical applications, concludes prospective insight into research development directions EPDEVs.
Язык: Английский
Процитировано
30
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 23, 2024
Abstract Background Recent research increasingly highlights a strong correlation between gut microbiota and the risk of gastrointestinal diseases. However, whether this relationship is causal or merely coincidental remains uncertain. To address this, Mendelian randomization (MR) analysis was undertaken to explore connections prevalent Methods Genome-wide association study (GWAS) summary statistics for microbiota, encompassing diverse range 211 taxa (131 genera, 35 families, 20 orders, 16 classes, 9 phyla), were sourced from comprehensive MiBioGen study. Genetic associations with 22 diseases gathered UK Biobank, FinnGen study, various extensive GWAS studies. MR meticulously conducted assess genetically predicted these validate reliability our findings, sensitivity analyses tests heterogeneity systematically performed. Results The yielded significant evidence 251 relationships This included 98 upper diseases, 81 lower 54 hepatobiliary 18 pancreatic Notably, particularly evident in belonging genera Ruminococcus Eubacterium . Further reinforced robustness results. Conclusions findings indicate potential genetic predisposition linking These insights pave way designing future clinical trials focusing on microbiome-related interventions, including use microbiome-dependent metabolites, potentially treat manage their associated factors.
Язык: Английский
Процитировано
17
Heliyon, Год журнала: 2024, Номер 10(2), С. e24207 - e24207
Опубликована: Янв. 1, 2024
High blood glucose levels are a hallmark of the metabolic syndrome known as diabetes mellitus. More than 600 million people will have by 2045 global prevalence disease continues to rise. Contemporary antidiabetic drugs reduce hyperglycemia and its consequences. However, these come with undesirable side effects, so it's encouraging that research into plant extracts bioactive substances characteristics is on Natural remedies preferable conventional anti-diabetic since they safer for body, more affordable fewer potential adverse effects. Biological macromolecules such liposomes, niosomes, polymeric nanoparticles, solid lipid nanoemulsions metallic nanoparticles explored in this review. Current drug restrictions been addressed, effectiveness plant-based therapies has enhanced merits methods. Plant extracts' loading capacity carriers' stability primary obstacles developing nanocarriers. Hydrophilic, hydrophobic, amphiphilic covered, brief overview amphipathic features phospholipids, nanocarriers provided. Metallic nanoparticles' benefits attendant risks highlighted emphasize their efficiency treating hyperglycemia. Researchers interested loaded therapeutics may find current helpful
Язык: Английский
Процитировано
12
International Journal of Physiology Pathophysiology and Pharmacology, Год журнала: 2024, Номер 16(1), С. 1 - 9
Опубликована: Янв. 1, 2024
Extracellular vesicles (EVs) have emerged as a captivating field of study in molecular biology with diverse applications therapeutics. These small membrane-bound structures, released by cells into the extracellular space, play vital role intercellular communication and hold immense potential for advancing medical treatments. EVs, including exosomes, microvesicles, apoptotic bodies, are classified based on size biogenesis pathways, exosomes being most extensively studied. The aim this was to examine secretory pathway discuss methods employing them laboratory models. therapeutic EVs has garnered significant attention. Their unique properties, such stability, biocompatibility, capacity traverse biological barriers, make promising vehicles targeted drug delivery. By engineering carry specific cargo molecules, proteins, interfering Ribonucleic Acid (RNAs) (siRNAs), or anti-cancer drugs, researchers can enhance stability improve their delivery tissues. This approach minimize off-target effects increase efficacy, offering more precise effective treatment strategy. represent rapidly evolving implications. communication, delivery, regenerative medicine makes valuable tools As our understanding EV continues expand, we expect remarkable advancements that will revolutionize lead personalized therapies.
Язык: Английский
Процитировано
11
Applied Materials Today, Год журнала: 2024, Номер 36, С. 102078 - 102078
Опубликована: Янв. 20, 2024
Язык: Английский
Процитировано
9
Phytomedicine, Год журнала: 2025, Номер 139, С. 156539 - 156539
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2678 - 2678
Опубликована: Март 16, 2025
Despite the substantial advances in cancer therapies, developing safe and effective treatment methodologies is critical. Natural (plant-derived compounds), such as flavonoids, might be crucial a methodology without toxicity toward healthy tissues. Prunin flavonoid with potential to used biomedical applications. has yet undergo thorough scientific research, its precise molecular mechanisms of action remain largely unexplored. This review summarizes therapeutic prunin for first time, focusing on underlying an anticancer compound. gained significant attention due antioxidant, anti-inflammatory, effects. aims unlock how functions at level exert effects, primarily modulating key cellular pathways. Furthermore, we have discussed prunin’s adjunctive therapy conventional treatments, highlighting ability strengthen responses while decreasing drug resistance. Moreover, discussion probes into innovative delivery methods, particularly nanoformulations, that address bioavailability, solubility, stability limitations optimize application. By providing comprehensive analysis properties, this stimulate further exploration using agent, thereby progressing development targeted, selective, safe, methods.
Язык: Английский
Процитировано
1
Inflammopharmacology, Год журнала: 2023, Номер 31(5), С. 2587 - 2597
Опубликована: Июль 11, 2023
Язык: Английский
Процитировано
21
Metabolites, Год журнала: 2023, Номер 13(6), С. 728 - 728
Опубликована: Июнь 6, 2023
Ongoing research explores the underlying causes of ulcerative colitis and Crohn’s disease. Many experts suggest that dysbiosis in gut microbiota genetic, immunological, environmental factors play significant roles. The term “microbiota” pertains to collective community microorganisms, including bacteria, viruses, fungi, reside within gastrointestinal tract, with a particular emphasis on colon. When there is an imbalance or disruption composition microbiota, it referred as dysbiosis. Dysbiosis can trigger inflammation intestinal cells disrupt innate immune system, leading oxidative stress, redox signaling, electrophilic inflammation. Nod-like Receptor (NLR) Family Pyrin Domain Containing 3 (NLRP3) inflammasome, key regulator found immunological epithelial cells, crucial inducing inflammatory diseases, promoting responses regulating integrity epithelium. Its downstream effectors include caspase-1 interleukin (IL)-1β. present study investigated therapeutic potential 13 medicinal plants, such Litsea cubeba, Artemisia anomala, Piper nigrum, Morus macroura, Agrimonia pilosa, 29 phytocompounds artemisitene, morroniside, protopine, ferulic acid, quercetin, picroside II, hydroxytyrosol vitro vivo models bowel diseases (IBD), focus their effects NLRP3 inflammasome. observed these treatments included reductions IL-1β, tumor necrosis factor-alpha, IL-6, interferon-gamma, caspase levels, increased expression antioxidant enzymes, IL-4, IL-10, well regulation microbiota. These could potentially provide substantial advantages treating IBD few no adverse caused by synthetic anti-inflammatory immunomodulated drugs. However, additional necessary validate findings clinically develop effective benefit individuals who suffer from diseases.
Язык: Английский
Процитировано
17
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Июнь 14, 2023
Pharmacological treatment of inflammatory bowel disease (IBD) is inefficient and difficult to discontinue appropriately, enterobacterial interactions are expected provide a new target for the IBD. We collected recent studies on among host, enterobacteria, their metabolite products discuss potential therapeutic options. Intestinal flora in IBD affected reduced bacterial diversity, impact immune system influenced by multiple factors such as host genetics diet. Enterobacterial metabolites SCFAs, bile acids, tryptophan also play important roles interactions, especially progression Therapeutically, wide range sources probiotics prebiotics exhibit benefit through some have gained recognition adjuvant drugs. Different dietary patterns foods, functional novel modalities that distinguish pro-and from traditional medications. Combined with food science may significantly improve experience patients In this review, we brief overview role enterobacteria advantages disadvantages options derived metabolites, postulate directions further research.
Язык: Английский
Процитировано
12