Wheat Bran Polyphenols Ameliorate DSS-Induced Ulcerative Colitis in Mice by Suppressing MAPK/NF-κB Inflammasome Pathways and Regulating Intestinal Microbiota

Foods, Год журнала: 2024, Номер 13(2), С. 225 - 225

Опубликована: Янв. 10, 2024

Wheat bran (WB) is the primary by-product of wheat processing and contains a high concentration bioactive substances such as polyphenols. This study analyzed qualitative quantitative components polyphenols in their effects on ulcerative colitis (UC) using dextran sulfate sodium (DSS)-induced model mice. The potential mechanism (WBP) was also examined. Our findings indicate that main polyphenol constituents WBP were phenolic acids, including vanillic acid, ferulic caffeic gallic protocatechuic acid. Furthermore, exerted remarkable protective against experimental colitis. achieved by reducing severity improving colon morphology. Additionally, suppressed colonic inflammation via upregulation anti-inflammatory cytokine IL-10 downregulation pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) tissues. Mechanistically, ameliorated DSS-induced mice inhibiting activation MAPK/NF-κB pathway. In addition, microbiome analysis results suggested modulated alteration gut microbiota caused DSS, with an enhancement ratio Firmicutes/Bacteroidetes adjustments number Helicobacter, Escherichia-Shigella, Akkermansia, Lactobacillus, Lachnospiraceae_NK4A136_group at genus level. To conclude, showed has excellent prospects UC

Язык: Английский

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Natural compounds target programmed cell death (PCD) signaling mechanism to treat ulcerative colitis: a review

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 9, 2024

Ulcerative colitis (UC) is a nonspecific inflammatory bowel disease characterized by abdominal pain, bloody diarrhea, weight loss, and colon shortening. However, UC difficult to cure due its high drug resistance rate easy recurrence. Moreover, long-term inflammation increased severity can lead the development of cancer in some patients. Programmed cell death (PCD) gene-regulated process that includes apoptosis, autophagy, necroptosis, ferroptosis, pyroptosis. PCD plays crucial role maintaining body homeostasis organs tissues. Abnormal signaling observed pathological UC, such as activating apoptosis pathway promote progression UC. Targeting may be therapeutic strategy, natural compounds have shown great potential modulating key targets treat For instance, baicalin regulate alleviate infiltration damage. This review focuses on specific expression interaction with multiple pathways, NF-κB, Nrf2, MAPK, JAK/STAT, PI3K/AKT, NLRP3, GPX4, Bcl-2, etc., elucidate targeting for treatment used (ulcerative colitis) (programmed death) (natural products) keywords search related studies PubMed Web Science, CNKI database past 10 years. work retrieved 72 (65 from 5 years 7 years), which aims provide new strategies patients serves foundation drugs.

Язык: Английский

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Targeting ferroptosis using Chinese herbal compounds to treat respiratory diseases

Phytomedicine, Год журнала: 2024, Номер 130, С. 155738 - 155738

Опубликована: Июнь 1, 2024

Respiratory diseases pose a grave threat to human life. Therefore, understanding their pathogenesis and therapeutic strategy is important. Ferroptosis novel type of iron-dependent programmed cell death, distinct from apoptosis, necroptosis, autophagy, characterised by iron, reactive oxygen species, lipid peroxide accumulation, as well glutathione (GSH) depletion GSH peroxidase 4 (GPX4) inactivation. A close association between ferroptosis the onset progression respiratory diseases, including chronic obstructive pulmonary disease, acute lung injury, bronchial asthma, fibrosis, cancer, has been reported. Recent studies have shown that traditional Chinese medicine (TCM) compounds exhibit unique advantages in treatment owing natural properties potential efficacy. These can effectively regulate modulating several key signalling pathways such system Xc

Язык: Английский

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Natural products modulating MAPK for CRC treatment: a promising strategy

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 5, 2025

Colorectal cancer (CRC) is a common malignant tumor of the digestive system, and pathogenic mechanism still unclear, mostly related to genetics, immunity, inflammation, abnormal activation tumor-related signaling pathways. MAPK belongs Ser/Thr kinase family, which plays an important role in complex cellular programs such as regulation cell proliferation, differentiation, apoptosis, angiogenesis, metastasis. Increasing evidence supports that highly correlated with risk CRC. Targeting may be therapeutic strategy, natural products show great potential regulating MAPK-related proteins. In this paper, we searched PubMed, Web Science CNKI databases keywords "colorectal cancer, products, pathway, ERK, P38, JNK" for relevant studies last 14 years from 2010 2024. This work retrieved 47 studies, aiming provide new strategies CRC patients lay foundation drug development.

Язык: Английский

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Mechanic evaluation of Wu-Mei-Pill on colitis-associated colorectal cancer: An integrated transcriptomics, metabolomics, and experimental validation study

Phytomedicine, Год журнала: 2024, Номер 128, С. 155509 - 155509

Опубликована: Март 2, 2024

Язык: Английский

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SIRT1/AMPK-mediated pathway: Ferulic acid from sugar beet pulp mitigating obesity-induced diabetes-linked complications and improving metabolic health

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2024, Номер 1869(7), С. 159511 - 159511

Опубликована: Май 16, 2024

Язык: Английский

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Ferulic acid interventions ameliorate NDEA-CCl4-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats

Toxicology Reports, Год журнала: 2024, Номер 12, С. 119 - 127

Опубликована: Янв. 18, 2024

Hepatocellular carcinoma is a prevalent form of liver cancer that life threatening. Many chemically synthesized anti-cancer drugs have various degrees side effects. Hence, this study investigated the effect FEAC interventions on NDEA-CCl4-induced HCAR in male Wistar rats. was induced by intraperitoneal administration 200 mg/kg NDEA and 0.5 mL/kg CCl4 (as promoter HCAR). Following induction HCAR, rats were treated differently with two different doses (25 50 mg/kg) FEAC. confirmed significant elevation serum levels ALT, AST, α-FP. Also elevated significantly Akt/PKB, NF-κB, TNF-α, MDA, GSH, activities GST, SOD, CAT, while p53 Nrf2 lowered compared normal Treatment both 25 against DEN-CCl4-induced gave comparable effects, marked reduction AST α-FP, as well Put together judging outcomes study, being potent antioxidant may also be chemical-induced via upregulation Nrf2, downregulation Akt/PKB-NF-κB pathway

Язык: Английский

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Millingtonia hortensis L.f. ethanol extract exerts in vivo and in vitro anti-inflammatory activities through inhibition of Syk kinase in NF-κB pathway

Journal of Ethnopharmacology, Год журнала: 2024, Номер 332, С. 118386 - 118386

Опубликована: Май 22, 2024

Язык: Английский

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Neuroimmune response and oxidative stress in the prefrontal cortex mediate seizure susceptibility in experimental colitis in male mice

Journal of Biochemical and Molecular Toxicology, Год журнала: 2024, Номер 38(7)

Опубликована: Июнь 26, 2024

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder. Oxidative stress and inflammatory responses have vital role in the pathophysiology of IBD as well seizure. associated with extraintestinal manifestations. This study aimed to explore relationship between colitis susceptibility seizures, focus on roles neuroinflammation oxidative acetic acid-induced mice. Forty male Naval Medical Research Institute mice were divided into four groups: control, colitis, pentylenetetrazole (PTZ), + PTZ. Colitis was induced by intrarectal administration acid, seizures intravenous injection PTZ 7 days postcolitis induction. Following measurement latency seizure, killed, their colons prefrontal cortex (PFC) dissected. Gene expression markers including interleukin-1β, tumor necrosis factor-alpha, NOD-like receptor protein 3, toll-like 4, total antioxidant capacity (TAC), malondialdehyde (MDA), nitrite levels measured colon PFC. Histopathological evaluations performed samples. Data analyzed t-test or one-way variance analysis. decreased increased gene markers, altered MDA, nitrite, TAC both Simultaneous induction seizure exacerbated neuroimmune response PFC colon. Results concluded that at least partially mediate comorbid decrease colitis.

Язык: Английский

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Therapeutic Implications of Phenolic Acids for Ameliorating Inflammatory Bowel Disease

Nutrients, Год журнала: 2024, Номер 16(9), С. 1347 - 1347

Опубликована: Апрель 29, 2024

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder, and its complex etiology makes prevention treatment challenging. Research on new drugs strategies currently focal point. Phenolic acids are widely present in plant-based diets have demonstrated the potential to alleviate colitis due their powerful antioxidant anti-inflammatory properties. In this review, we provide an overview of structures main dietary sources phenolic acids, encompassing benzoic acid cinnamic acid. Additionally, explore as nutritional therapy for preventing treating IBD. animal cell experiments, effectively IBD induced by drug exposure or genetic defects. The mechanisms include improving mucosal barrier function, reducing oxidative stress, inhibiting excessive activation immune response, regulating balance microbiota. Our observation points towards need additional basic clinical investigations derivatives novel therapeutic agents

Язык: Английский

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