Pharmacokinetics of Dihydroquercetin after Single and Repeated Administration to Rats

Bulletin of Experimental Biology and Medicine, Год журнала: 2024, Номер 176(6), С. 743 - 746

Опубликована: Апрель 1, 2024

Язык: Английский

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Physicochemical Properties, Antioxidant Activity, and High-Performance Thin-Layer Chromatography Profiling of Propolis Samples from Western Australia

Plants, Год журнала: 2024, Номер 13(14), С. 1919 - 1919

Опубликована: Июль 11, 2024

This study reports on the physicochemical and antioxidant properties of propolis samples from various regions across Western Australia identifies some phenolic constituents using high-performance thin-layer chromatography (HPTLC). Total content (TPC) was determined a modified Folin-Ciocalteu assay, activity investigated with Ferric Reducing Antioxidant Power (FRAP) assay also visualised semi-quantified by HPTLC-DPPH analysis. TPC values ranged 9.26 to 59.3 mg gallic acid equivalent/g raw FRAP data 4.34 53.8 mmol Fe

Язык: Английский

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Unveiling the therapeutic potential of Taxifolin in Cancer: From molecular mechanisms to immune modulation and synergistic combinations

Phytomedicine, Год журнала: 2024, Номер 133, С. 155934 - 155934

Опубликована: Авг. 3, 2024

Язык: Английский

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Pathological Alterations in Heart Mitochondria in a Rat Model of Isoprenaline-Induced Myocardial Injury and Their Correction with Water-Soluble Taxifolin

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11596 - 11596

Опубликована: Окт. 29, 2024

Mitochondrial damage and associated oxidative stress are considered to be major contributory factors in cardiac pathology. One of the most potent naturally occurring antioxidants is taxifolin, especially its water-soluble form. Herein, effect a 14-day course peroral application taxifolin (aqTAX, 15 mg/kg body weight) on progression ultrastructural functional disorders mitochondria heart’s electrical activity rat model myocardial injury induced with isoprenaline (ISO, 150 mg/kg/day for two consecutive days, subcut) was studied. The delayed ISO-induced accompanied by an increase duration RR QT intervals, long-term aqTAX partially restored disturbed intraventricular conduction. It shown that injections ISO lead profound alterations myofibrils cardiomyocytes left ventricle myocardium, including impairment ordered arrangement between as well decrease size number these organelles per unit area. In addition, reduction protein level subunits respiratory chain complexes I-V antioxidant enzymes catalase, glutathione peroxidase, Mn-SOD observed. caused efficiency oxidation phosphorylation partial restoration morphometric parameters heart tissue animals experimental These beneficial effects inhibition lipid peroxidation normalization enzymatic activities peroxidase mitochondria, which may reduce organelles. Taken together, data allow one consider this compound promising cardioprotector complex therapy failure.

Язык: Английский

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Enhanced efficacy of quercetin and taxifolin encapsulated with pH-responsive injectable BSA hydrogel for targeting triple-negative breast cancer cells

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138477 - 138477

Опубликована: Дек. 11, 2024

Язык: Английский

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