Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 13, 2025
Resveratrol,
a
polyphenolic
compound
known
for
its
diverse
biological
activities,
has
demonstrated
multiple
pharmacological
effects,
including
anti-inflammatory,
anti-aging,
anti-diabetic,
anti-cancer,
and
cardiovascular
protective
properties.
Recent
studies
suggest
that
these
effects
are
partly
mediated
through
the
regulation
of
macrophage
polarization,
wherein
macrophages
differentiate
into
pro-inflammatory
M1
or
anti-inflammatory
M2
phenotypes.
Our
review
highlights
how
resveratrol
modulates
polarization
various
signaling
pathways
to
achieve
therapeutic
effects.
For
example,
can
activate
senescence-associated
secretory
phenotype
(SASP)
pathway
inhibit
signal
transducer
activator
transcription
(STAT3)
sphingosine-1-phosphate
(S1P)-YAP
axes,
promoting
suppressing
thereby
inhibiting
tumor
growth.
Conversely,
it
promote
suppress
by
NF-κB
activating
PI3K/Akt
AMP-activated
protein
kinase
(AMPK)
pathways,
thus
alleviating
inflammatory
responses.
Notably,
effect
on
is
concentration-dependent;
moderate
concentrations
tend
while
higher
may
favor
polarization.
This
concentration
dependence
offers
new
perspectives
clinical
treatment
but
also
underscores
necessity
precise
dosage
control
when
using
resveratrol.
In
summary,
exhibits
significant
potential
in
regulating
treating
related
diseases.
Язык: Английский
Enhancing Oral 5-ASA Effectiveness in Mild-to-Moderate Ulcerative Colitis through an H. erinaceus-Based Nutraceutical Add-on Multi-Compound: The “HERICIUM-UC” Two-Arm Multicentre Retrospective Study
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1133 - 1133
Опубликована: Авг. 28, 2024
Mild-to-moderate
ulcerative
colitis
(UC)
management
is
centred
on
5-aminosalicylic
acid
(5-ASA)
derivatives.
Whether
supplementing
5-ASA
with
nutraceuticals
can
provide
real
advantages
in
UC-relevant
outcomes
unclear.
This
retrospective
multicentre
study
compared
clinical
remission,
response
rates,
and
faecal
calprotectin
levels
a
two-arm
design,
including
patients
treated
alone
those
additional
H.
erinaceus-based
multi-compound
supplementation.
In
the
group,
rates
were
41%
at
three
months
(T1)
60.2%
six
(T2),
while
corresponding
remission
16.9%
36.1%.
nutraceutical
supplementation
49.6%
70.4%
of
30.4%
50.9%
(T2).
No
significant
differences
between
groups
T1
(p
=
0.231)
T2
0.143)
emerged.
Clinical
differed
significantly
both
time
points
0.029
p
0.042,
respectively).
Faecal
decreased
during
follow-up
<
0.05),
this
was
more
pronounced
0.005)
0.01).
adverse
events
reported.
multi-component
offers
real-world
potential
controlling
disease
activity
mild-to-moderate
UC.
Язык: Английский
Targeting Gut Microbiota with Probiotics and Phenolic Compounds in the Treatment of Atherosclerosis: A Comprehensive Review
Foods,
Год журнала:
2024,
Номер
13(18), С. 2886 - 2886
Опубликована: Сен. 12, 2024
Atherosclerosis
(AS)
is
a
chronic
inflammatory
vascular
disease.
Dysregulated
lipid
metabolism,
oxidative
stress,
and
inflammation
are
the
major
mechanisms
implicated
in
development
of
AS.
In
addition,
evidence
suggests
that
gut
dysbiosis
plays
an
important
role
atherogenesis,
modulation
microbiota
with
probiotics
phenolic
compounds
has
emerged
as
promising
strategy
for
preventing
treating
It
been
shown
can
improve
atherosclerosis-related
parameters
by
improving
profile,
inflammation.
these
may
modulate
diversity
composition
atherosclerosis.
The
studies
evaluated
present
review
showed
compounds,
when
consumed
individually,
improved
atherosclerosis
modulating
various
ways,
such
decreasing
permeability,
TMAO
LPS
levels,
altering
alpha
beta
diversity,
increasing
fecal
bile
acid
loss.
However,
no
study
was
found
combined
use
to
available
literature
highlights
synergistic
potential
between
their
health-promoting
properties
functionalities.
This
aims
summarize
on
individual
effects
AS,
while
providing
insights
into
benefits
nutraceutical
approaches
using
probiotic
strains,
quercetin,
resveratrol
adjuvant
therapies
AS
treatment
through
microbiota.
Язык: Английский
PLGA-LEC/F127 hybrid nanoparticles loaded with curcumin and their modulatory effect on monocytes
Nanomedicine,
Год журнала:
2024,
Номер
19(15), С. 1407 - 1423
Опубликована: Июнь 20, 2024
To
investigate
the
effect
of
surfactant
type
on
curcumin-loaded
(CUR)
PLGA
nanoparticles
(NPs)
to
modulate
monocyte
functions.
Язык: Английский
Innovative Approaches in Atherosclerosis Treatment: Harnessing Traditional Chinese Medicine to Target Long Non-Coding RNAs
Phytomedicine,
Год журнала:
2025,
Номер
139, С. 156488 - 156488
Опубликована: Фев. 9, 2025
Язык: Английский
Protocatechuic Acid Attenuates Inflammation in Macrophage-like Vascular Smooth Muscle Cells in ApoE−/− Mice
Nutrients,
Год журнала:
2025,
Номер
17(6), С. 1090 - 1090
Опубликована: Март 20, 2025
Background/Objectives:
Non-resolving
inflammation
in
macrophage-like
cells
(MLCs)
transdifferentiated
from
vascular
smooth
muscle
and
monocyte-derived
macrophages
aggravates
atherosclerosis.
We
previously
showed
that
polyphenolic
protocatechuic
acid
(PCA)
could
reduce
burden
macrophages;
however,
it
remains
unknown
how
this
compound
affects
MLCs
inflammation.
Methods:
the
transdifferentiation
of
induced
by
cholesterol
30-week-old
male
ApoE−/−
mice
fed
a
semi-purified
AIN-93G
diet
containing
either
0.003%
(wt:wt)
PCA
for
duration
20
weeks
were
used
to
examine
impact
on
inflammatory
response
MLCs.
Results:
Physiologically
achievable
doses
(0.25–1
μM)
dose-dependently
inhibited
lipopolysaccharide-induced
NF-κB
activation
simultaneously
reduced
pro-inflammatory
cytokine
levels.
Mechanistically,
effect
was
mediated
effecting
exportin-1
function,
promoting
nuclear
export
phosphorylated-p65,
independent
kinase
inhibitor
α/β/γ,
α,
or
importin-mediated
import
p-p65.
nucleocytoplasmic
ratio
(44%)
without
altering
its
abundance.
Importantly,
dietary
supplementation
with
interleukin-1β
content
within
atherosclerotic
plaques
mice.
In
addition,
plaques.
Conclusions:
attenuate
targeting
also
inhibit
into
plaques,
which
might
promote
translation
preclinical
studies
clinical
trials
patients
Язык: Английский
Moderate-intensity continuous training and high-intensity interval training alleviate glycolipid metabolism through modulation of gut microbiota and their metabolites SCFAs in diabetic rats
Yuxia Han,
Hongjiao Quan,
Wei Ji
и другие.
Biochemical and Biophysical Research Communications,
Год журнала:
2024,
Номер
735, С. 150831 - 150831
Опубликована: Окт. 13, 2024
Язык: Английский
Inhibition of CTLA-4 accelerates atherosclerosis in hyperlipidemic mice by modulating the Th1/Th2 balance via the NF-κB signaling pathway
Heliyon,
Год журнала:
2024,
Номер
10(17), С. e37278 - e37278
Опубликована: Авг. 31, 2024
Though
an
increased
risk
of
atherosclerosis
is
associated
with
anti-CTLA-4
antibody
therapy,
the
underlying
mechanisms
remain
unclear.
Язык: Английский
PGC1α enhances macrophage efferocytosis in ox-LDL-stimulated RAW264.7 cells by regulating the NLRP3/PPARα axis
Tissue and Cell,
Год журнала:
2024,
Номер
90, С. 102476 - 102476
Опубликована: Июль 14, 2024
Язык: Английский
Efficacy of Compound Xueshuantong Capsule in Reducing Cardiovascular Diseases and Associated Ophthalmic Complications: A Multi-Center Retrospective Study
Journal of Herbal Medicine,
Год журнала:
2024,
Номер
unknown, С. 100943 - 100943
Опубликована: Сен. 1, 2024
Язык: Английский