Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 13, 2025

Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Our review highlights how resveratrol modulates polarization various signaling pathways to achieve therapeutic effects. For example, can activate senescence-associated secretory phenotype (SASP) pathway inhibit signal transducer activator transcription (STAT3) sphingosine-1-phosphate (S1P)-YAP axes, promoting suppressing thereby inhibiting tumor growth. Conversely, it promote suppress by NF-κB activating PI3K/Akt AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. Notably, effect on is concentration-dependent; moderate concentrations tend while higher may favor polarization. This concentration dependence offers new perspectives clinical treatment but also underscores necessity precise dosage control when using resveratrol. In summary, exhibits significant potential in regulating treating related diseases.

Language: Английский

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Enhancing Oral 5-ASA Effectiveness in Mild-to-Moderate Ulcerative Colitis through an H. erinaceus-Based Nutraceutical Add-on Multi-Compound: The “HERICIUM-UC” Two-Arm Multicentre Retrospective Study

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1133 - 1133

Published: Aug. 28, 2024

Mild-to-moderate ulcerative colitis (UC) management is centred on 5-aminosalicylic acid (5-ASA) derivatives. Whether supplementing 5-ASA with nutraceuticals can provide real advantages in UC-relevant outcomes unclear. This retrospective multicentre study compared clinical remission, response rates, and faecal calprotectin levels a two-arm design, including patients treated alone those additional H. erinaceus-based multi-compound supplementation. In the group, rates were 41% at three months (T1) 60.2% six (T2), while corresponding remission 16.9% 36.1%. nutraceutical supplementation 49.6% 70.4% of 30.4% 50.9% (T2). No significant differences between groups T1 (p = 0.231) T2 0.143) emerged. Clinical differed significantly both time points 0.029 p 0.042, respectively). Faecal decreased during follow-up < 0.05), this was more pronounced 0.005) 0.01). adverse events reported. multi-component offers real-world potential controlling disease activity mild-to-moderate UC.

Language: Английский

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Targeting Gut Microbiota with Probiotics and Phenolic Compounds in the Treatment of Atherosclerosis: A Comprehensive Review

Foods, Journal Year: 2024, Volume and Issue: 13(18), P. 2886 - 2886

Published: Sept. 12, 2024

Atherosclerosis (AS) is a chronic inflammatory vascular disease. Dysregulated lipid metabolism, oxidative stress, and inflammation are the major mechanisms implicated in development of AS. In addition, evidence suggests that gut dysbiosis plays an important role atherogenesis, modulation microbiota with probiotics phenolic compounds has emerged as promising strategy for preventing treating It been shown can improve atherosclerosis-related parameters by improving profile, inflammation. these may modulate diversity composition atherosclerosis. The studies evaluated present review showed compounds, when consumed individually, improved atherosclerosis modulating various ways, such decreasing permeability, TMAO LPS levels, altering alpha beta diversity, increasing fecal bile acid loss. However, no study was found combined use to available literature highlights synergistic potential between their health-promoting properties functionalities. This aims summarize on individual effects AS, while providing insights into benefits nutraceutical approaches using probiotic strains, quercetin, resveratrol adjuvant therapies AS treatment through microbiota.

Language: Английский

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Protocatechuic Acid Attenuates Inflammation in Macrophage-like Vascular Smooth Muscle Cells in ApoE−/− Mice

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1090 - 1090

Published: March 20, 2025

Background/Objectives: Non-resolving inflammation in macrophage-like cells (MLCs) transdifferentiated from vascular smooth muscle and monocyte-derived macrophages aggravates atherosclerosis. We previously showed that polyphenolic protocatechuic acid (PCA) could reduce burden macrophages; however, it remains unknown how this compound affects MLCs inflammation. Methods: the transdifferentiation of induced by cholesterol 30-week-old male ApoE−/− mice fed a semi-purified AIN-93G diet containing either 0.003% (wt:wt) PCA for duration 20 weeks were used to examine impact on inflammatory response MLCs. Results: Physiologically achievable doses (0.25–1 μM) dose-dependently inhibited lipopolysaccharide-induced NF-κB activation simultaneously reduced pro-inflammatory cytokine levels. Mechanistically, effect was mediated effecting exportin-1 function, promoting nuclear export phosphorylated-p65, independent kinase inhibitor α/β/γ, α, or importin-mediated import p-p65. nucleocytoplasmic ratio (44%) without altering its abundance. Importantly, dietary supplementation with interleukin-1β content within atherosclerotic plaques mice. In addition, plaques. Conclusions: attenuate targeting also inhibit into plaques, which might promote translation preclinical studies clinical trials patients

Language: Английский

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Innovative Approaches in Atherosclerosis Treatment: Harnessing Traditional Chinese Medicine to Target Long Non-Coding RNAs

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156488 - 156488

Published: Feb. 9, 2025

Language: Английский

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PLGA-LEC/F127 hybrid nanoparticles loaded with curcumin and their modulatory effect on monocytes

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(15), P. 1407 - 1423

Published: June 20, 2024

To investigate the effect of surfactant type on curcumin-loaded (CUR) PLGA nanoparticles (NPs) to modulate monocyte functions.

Language: Английский

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Moderate-intensity continuous training and high-intensity interval training alleviate glycolipid metabolism through modulation of gut microbiota and their metabolites SCFAs in diabetic rats

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 735, P. 150831 - 150831

Published: Oct. 13, 2024

Language: Английский

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Inhibition of CTLA-4 accelerates atherosclerosis in hyperlipidemic mice by modulating the Th1/Th2 balance via the NF-κB signaling pathway

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37278 - e37278

Published: Aug. 31, 2024

Though an increased risk of atherosclerosis is associated with anti-CTLA-4 antibody therapy, the underlying mechanisms remain unclear.

Language: Английский

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PGC1α enhances macrophage efferocytosis in ox-LDL-stimulated RAW264.7 cells by regulating the NLRP3/PPARα axis

Tissue and Cell, Journal Year: 2024, Volume and Issue: 90, P. 102476 - 102476

Published: July 14, 2024

Language: Английский

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Efficacy of Compound Xueshuantong Capsule in Reducing Cardiovascular Diseases and Associated Ophthalmic Complications: A Multi-Center Retrospective Study

Journal of Herbal Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100943 - 100943

Published: Sept. 1, 2024

Language: Английский

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