Role of long non-coding RNAs and natural products in prostate cancer: insights into key signaling pathways
Functional & Integrative Genomics,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 17, 2025
Язык: Английский
The Function of Circular RNAs in Regulating Wnt/β-Catenin Signaling: An Innovative Therapeutic Strategy for breast and gynecological Cancers
Pathology - Research and Practice,
Год журнала:
2025,
Номер
unknown, С. 155944 - 155944
Опубликована: Март 1, 2025
Язык: Английский
The molecular mechanisms of glycosaminoglycan biosynthesis regulating chondrogenesis and endochondral ossification
Life Sciences,
Год журнала:
2023,
Номер
335, С. 122243 - 122243
Опубликована: Ноя. 8, 2023
Язык: Английский
The dual roles of circRNAs in Wnt/β-Catenin signaling and cancer progression
Pathology - Research and Practice,
Год журнала:
2024,
Номер
255, С. 155132 - 155132
Опубликована: Фев. 1, 2024
Язык: Английский
Updated review on analysis of long non-coding RNAs as emerging diagnostic and therapeutic targets in prostate cancers
Critical Reviews in Oncology/Hematology,
Год журнала:
2024,
Номер
196, С. 104275 - 104275
Опубликована: Фев. 1, 2024
Язык: Английский
Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9195 - 9195
Опубликована: Авг. 24, 2024
Prostate
cancer
(PC)
is
a
significant
cause
of
mortality
in
men
worldwide,
hence
the
need
for
comprehensive
understanding
molecular
mechanisms
underlying
its
progression
and
resistance
to
treatment.
Heme
oxygenase-1
(HO-1),
an
inducible
enzyme
involved
heme
catabolism,
has
emerged
as
critical
player
biology,
including
PC.
This
review
explores
multifaceted
role
HO-1
PC,
encompassing
function,
regulation,
implications
therapy.
influences
cell
proliferation,
anti-apoptotic
pathways,
angiogenesis,
tumor
microenvironment,
thereby
influencing
growth
metastasis.
also
been
associated
with
therapy
resistance,
affecting
response
standard
treatments.
Moreover,
plays
immune
modulation,
microenvironment
potentially
outcomes.
Understanding
intricate
balance
PC
vital
developing
effective
therapeutic
strategies.
further
potential
targeting
approach,
highlighting
challenges
opportunities.
Additionally,
clinical
are
discussed,
focusing
on
prognostic
value
expression
development
novel
combined
therapies
augment
sensitivity
treatment
Ultimately,
unraveling
complexities
biology
will
provide
insights
into
personalized
approaches
patients.
Язык: Английский
RNA Structure: Past, Future, and Gene Therapy Applications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 110 - 110
Опубликована: Дек. 26, 2024
First
believed
to
be
a
simple
intermediary
between
the
information
encoded
in
deoxyribonucleic
acid
and
that
functionally
displayed
proteins,
ribonucleic
(RNA)
is
now
known
have
many
functions
through
its
abundance
intricate,
ubiquitous,
diverse,
dynamic
structure.
About
70–90%
of
human
genome
transcribed
into
protein-coding
noncoding
RNAs
as
main
determinants
along
with
regulatory
sequences
cellular
populational
biological
diversity.
From
nucleotide
sequence
or
primary
structure,
Watson–Crick
pairing
self-folding
secondary
compaction
via
longer
distance
non-Watson–Crick
interactions
tertiary
RNA
other
biopolymers
quaternary
metabolites
biomolecules
quinary
structure
plays
critical
role
RNA’s
lifecycle
from
transcription
decay
processes.
In
contrast
success
3-dimensional
protein
prediction
using
AlphaFold,
beyond
structures
remains
challenging.
However,
approaches
involving
machine
learning
artificial
intelligence,
sequencing
modifications,
structural
analyses
at
single-cell
intact
tissue
levels,
among
others,
provide
an
optimistic
outlook
for
continued
development
refinement
RNA-based
applications.
Here,
we
highlight
those
gene
therapy.
Язык: Английский