Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy DOI Open Access
Ramia J. Salloom, Iman M. Ahmad,

Dania Z. Sahtout

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9195 - 9195

Published: Aug. 24, 2024

Prostate cancer (PC) is a significant cause of mortality in men worldwide, hence the need for comprehensive understanding molecular mechanisms underlying its progression and resistance to treatment. Heme oxygenase-1 (HO-1), an inducible enzyme involved heme catabolism, has emerged as critical player biology, including PC. This review explores multifaceted role HO-1 PC, encompassing function, regulation, implications therapy. influences cell proliferation, anti-apoptotic pathways, angiogenesis, tumor microenvironment, thereby influencing growth metastasis. also been associated with therapy resistance, affecting response standard treatments. Moreover, plays immune modulation, microenvironment potentially outcomes. Understanding intricate balance PC vital developing effective therapeutic strategies. further potential targeting approach, highlighting challenges opportunities. Additionally, clinical are discussed, focusing on prognostic value expression development novel combined therapies augment sensitivity treatment Ultimately, unraveling complexities biology will provide insights into personalized approaches patients.

Language: Английский

Role of long non-coding RNAs and natural products in prostate cancer: insights into key signaling pathways DOI
Ahmed S. Doghish,

Sherif S. Abdel Mageed,

Mohamed Bakr Zaki

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 17, 2025

Language: Английский

Citations

1
The molecular mechanisms of glycosaminoglycan biosynthesis regulating chondrogenesis and endochondral ossification DOI
Yongjian Chen, Khalid Mehmood, Yung‐Fu Chang

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 335, P. 122243 - 122243

Published: Nov. 8, 2023

Language: Английский

Citations

17
The Function of Circular RNAs in Regulating Wnt/β-Catenin Signaling: An Innovative Therapeutic Strategy for breast and gynecological Cancers DOI

Samaneh Kahkesh,

Neda Hedayati,

Payman Rahimzadeh

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155944 - 155944

Published: March 1, 2025

Language: Английский

Citations

0
Updated review on analysis of long non-coding RNAs as emerging diagnostic and therapeutic targets in prostate cancers DOI
Zongpan Ke, Xuechun Hu,

Yixun Liu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 196, P. 104275 - 104275

Published: Feb. 1, 2024

Language: Английский

Citations

3
The dual roles of circRNAs in Wnt/β-Catenin signaling and cancer progression DOI
Waleed Hassan Almalki, Salem Salman Almujri

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155132 - 155132

Published: Feb. 1, 2024

Language: Английский

Citations

3
RNA Structure: Past, Future, and Gene Therapy Applications DOI Open Access
William A. Haseltine,

Kim Hazel,

Roberto Patarca

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 110 - 110

Published: Dec. 26, 2024

First believed to be a simple intermediary between the information encoded in deoxyribonucleic acid and that functionally displayed proteins, ribonucleic (RNA) is now known have many functions through its abundance intricate, ubiquitous, diverse, dynamic structure. About 70–90% of human genome transcribed into protein-coding noncoding RNAs as main determinants along with regulatory sequences cellular populational biological diversity. From nucleotide sequence or primary structure, Watson–Crick pairing self-folding secondary compaction via longer distance non-Watson–Crick interactions tertiary RNA other biopolymers quaternary metabolites biomolecules quinary structure plays critical role RNA’s lifecycle from transcription decay processes. In contrast success 3-dimensional protein prediction using AlphaFold, beyond structures remains challenging. However, approaches involving machine learning artificial intelligence, sequencing modifications, structural analyses at single-cell intact tissue levels, among others, provide an optimistic outlook for continued development refinement RNA-based applications. Here, we highlight those gene therapy.

Language: Английский

Citations

1
Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy DOI Open Access
Ramia J. Salloom, Iman M. Ahmad,

Dania Z. Sahtout

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9195 - 9195

Published: Aug. 24, 2024

Prostate cancer (PC) is a significant cause of mortality in men worldwide, hence the need for comprehensive understanding molecular mechanisms underlying its progression and resistance to treatment. Heme oxygenase-1 (HO-1), an inducible enzyme involved heme catabolism, has emerged as critical player biology, including PC. This review explores multifaceted role HO-1 PC, encompassing function, regulation, implications therapy. influences cell proliferation, anti-apoptotic pathways, angiogenesis, tumor microenvironment, thereby influencing growth metastasis. also been associated with therapy resistance, affecting response standard treatments. Moreover, plays immune modulation, microenvironment potentially outcomes. Understanding intricate balance PC vital developing effective therapeutic strategies. further potential targeting approach, highlighting challenges opportunities. Additionally, clinical are discussed, focusing on prognostic value expression development novel combined therapies augment sensitivity treatment Ultimately, unraveling complexities biology will provide insights into personalized approaches patients.

Language: Английский

Citations

1