Exploring the potential of saponins from Dicotyledonous plants in sustainable pest management: innovations and challenges; A reveiw
Journal of Natural Pesticide Research,
Год журнала:
2025,
Номер
unknown, С. 100111 - 100111
Опубликована: Янв. 1, 2025
Язык: Английский
TGR5 Activation by Dietary Bioactives and Related Improvement in Mitochondrial Function for Alleviating Diabetes and Associated Complications
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Takeda
G
protein-coupled
receptor
5
(TGR5),
also
known
as
bile
acid
1
(GPBAR1),
is
a
cell
surface
involved
in
key
physiological
processes,
including
glucose
homeostasis
and
energy
metabolism.
Recent
research
has
focused
on
the
role
of
TGR5
activation
preventing
or
treating
diabetes
while
highlighting
its
potential
impact
progression
diabetic
complications.
Functional
foods
edible
plants
have
emerged
valuable
sources
natural
compounds
that
can
activate
TGR5,
offering
therapeutic
benefits
for
management.
Despite
growing
interest,
studies
by
dietary
bioactive
remain
scattered.
This
Review
aims
to
provide
comprehensive
analysis
how
bioactives
act
agents
managing
It
explores
mechanisms
through
both
direct
agonistic
effects
indirect
pathways
via
modulation
gut
microbiota
Язык: Английский
Saponins as Natural Emulsifiers: Challenges, Regulatory Landscape, and Future in Biomedical and Cosmetic Fields
Industrial & Engineering Chemistry Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Язык: Английский
Quality and composition control of complex TCM preparations through a novel “Herbs-in vivo Compounds-Targets-Pathways” network methodology: the case of Lianhuaqingwen capsules
Simian Chen,
Hui Qi,
Chunyan Zhu
и другие.
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107650 - 107650
Опубликована: Фев. 1, 2025
Lianhuaqingwen
(LHQW)
capsules,
a
Chinese
patent
medicine,
consist
of
13
herbal
ingredients
and
are
widely
used
for
respiratory
diseases.
However,
the
complex
composition
LHQW
poses
challenges
in
assessing
its
quality
consistency.
In
this
study,
comprehensive
network
was
constructed
by
integrating
Digital
RNA
with
pertUrbation
Genes
(DRUG)-seq,
sequencing,
pharmacodynamic
data.
This
enables
rapid
systematic
screening
compounds
that
exhibit
high-exposure
vivo
significant
activity
potential,
serving
as
potential
control
markers.
details,
DRUG-seq
employed
to
evaluate
gene
expression
alterations
peripheral
blood
mononuclear
cells
derived
from
healthy
volunteers.
Ultrahigh-performance
liquid
chromatography
coupled
high-resolution
mass
spectrometry
(UPLC-HRMS)
analyze
components
rats,
identifying
total
505
compounds.
Additionally,
absorption,
distribution,
metabolism,
excretion
(ADME)
profiles
were
plotted
27
primary
LHQW.
And
an
HPLC-MS/MS
method
quantified
46
LHQW,
15
them
identified
markers
high
exposure
levels.
These
exhibited
inhibitory
effects
on
lipopolysaccharide
(LPS)-induced
pneumonia
mice,
mechanisms
predicted
RNA-seq
verified
RT-qPCR.
summary,
study
successfully
"Herbs-
Compounds-targets-pathways"
network,
offering
novel
insights
into
establishing
foundation
enhancing
measures.
Язык: Английский
Comprehensive assessment of antioxidant, antidiabetic, and anti-glycation properties of aqueous and methanolic extracts from Pistacia lentiscus L. leaves: a potential natural source for managing oxidative stress and diabetes-related complications
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 21, 2025
This
study
evaluates
the
phenolic
and
flavonoid
contents,
as
well
antioxidant,
antidiabetic,
anti-glycation
properties
of
aqueous
methanolic
extracts
from
Pistacia
lentiscus
L.
leaves.
The
antioxidant
activity
was
assessed
using
DPPH,
ABTS,
FRAP,
iron-chelation
assays,
revealing
superior
in
extract.
Both
exhibited
potent
antidiabetic
effects
by
inhibiting
digestive
enzyme
alpha-amylase,
with
IC50
values
2,291
±
0.002
μg/mL
(aqueous)
2,889
(methanolic).
Additionally,
demonstrated
significant
activity,
reducing
advanced
glycation
end-product
(AGE)
formation,
fructosamine
levels,
protecting
thiol
groups,
extract
providing
greater
protection.
These
findings
underscore
potential
P.
a
natural
source
bioactive
compounds
for
managing
oxidative
stress
diabetes-related
complications.
Язык: Английский
Sources, metabolism, health benefits and future development of saponins from plants
Food Research International,
Год журнала:
2024,
Номер
197, С. 115226 - 115226
Опубликована: Окт. 22, 2024
Язык: Английский
Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives
Nanotechnology Reviews,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 1, 2024
Abstract
Childhood
rhinitis
is
an
inflammatory
condition
affecting
the
nasal
mucosa
of
children
worldwide.
The
physical,
social,
and
cognitive
performance
affected
by
chronic
symptoms
childhood
rhinitis.
Effective
treatment
essential
to
avoid
long-term
effects
on
children’s
lifestyles
well-being.
Traditional
Chinese
medicine
(TCM)
has
been
used
treat
prevent
several
illnesses,
it
plays
a
crucial
role
in
healthcare
rehabilitation.
TCM
traditionally
holistically
However,
drawbacks
TCMs,
such
as
their
poor
water
solubility,
low
bioavailability,
single-use,
targeting
ability,
severely
restrict
use.
In
recent
years,
nanotechnology
for
various
drugs
improve
therapeutic
effectiveness
reduce
associated
adverse
effects.
Nanomaterials
formulations
are
synthesized
be
compatible
with
herbal
extracts
sustain
active
component
qualities.
Nanocarrier-based
drug
delivery
improves
circulation
time,
targeted
distribution,
resolving
administration
issues.
This
review
assesses
innovative
combination
developments
rhinitis,
providing
insights
into
novel
approaches.
also
provides
significant
potential
this
multidisciplinary
approach
transform
techniques
offers
road
map
future
research
initiatives
promising
sector.
Язык: Английский
Influence of saponin tauroside Sx1 on lifespan and expression of vitamin D receptors in the liver tissue of mice with influenza infection
Drug development & registration,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Introduction.
Respiratory
infections,
including
influenza,
are
often
accompanied
by
hepatitis
in
humans
which
pathogenesis
is
not
fully
understood.
According
to
the
available
datan
D
deficiency
presumably
a
risk
factor
occurrence
of
acute
respiratory
viral
infections
due
its
modulation
immune
response.
Recent
studies
indicate
that
several
plant
compounds
can
interact
with
vitamin
receptors
(VDRs)
and
modulate
activity
VDRs.
The
biologically
active
components
saponins
have
found
widespread
use
clinical
practice
their
wide
range
biological
pharmacological
effects
mechanisms
still
largely
unclear.
Aim.
To
study
effect
oral
administration
saponin
tauroside
Sx1,
obtained
from
Crimean
ivy,
on
life
expectancy
activation
liver
mice
during
experimental
infection
varying
severity.
Materials
methods.
11
subgroups
were
formed
male
BALB/c
mice,
used
experiment
depending
infectious
dose
influenza
virus,
5
LD
50
virus
or
10
respectively,
control.
Saponin
Sx1
was
as
corrector.
Immunohistochemical
carried
out
automatically
BOND-MAX
immunohistainer
(Leica,
Germany).
Primary
rabbit
polyclonal
antibodies
receptor
used.
Results
discussion.
Due
at
200
μg/mouse/day
increases
average
animals
receiving
4.6
days.
Reducing
IV
also
changed
onset
death
2
days
both
groups.
With
different
doses
10th
day
subgroups,
expression
changes
without
correction.
In
subgroup
2V,
number
total
positive
cells
lower
than
control
group.
Moreover,
2Vir
subgroup,
VDR
significantly
higher
Conclusion.
µg/mouse/day
has
fairly
pronounced
antiviral
A/H1N1
manifested
an
increase
(for
days)
decrease
mortality
rate
severe
infection,
compared
group,
where
100
%
observed
14th
experiment.
introduction
4th
all
reduces
intensively
express
VDR.
Язык: Английский