Jiedu Huayu Extract Alleviate Acute Liver Failure via Promotion of GPX4 Expression and Inhibition of D-GalN/LPS-Induced Ferroptosis DOI Creative Commons
Yong Lin, Yong Du, Minggang Wang

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(12)

Published: Dec. 1, 2024

Objective This study aims to explore the potential mechanisms of Jiedu Huayu granules (JDHY) mitigate D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced acute liver failure (ALF) in a cell damage model. Methods ALF was modeled using various concentrations D-GalN + LPS. JDHY-medicated serum at different then co-cultured with model proportion. The best concentration time intervention were determined by Cell Counting Kit-8, Alanine Aminotransferase (ALT), Aspartate (AST). Western blot used assess expression Ferritin Heavy Chain 1 (FTH1), Transferrin Receptor 1(TfR1), Glutathione Peroxidase 4 (GPX4), Lysyl Oxidase (LOX), Prostaglandin-Endoperoxide Synthase 2(PTGS2). Malondialdehyde analyzed for lipid peroxidation, enzyme-linked immunosorbent assay detect glutathione, Tumor Necrosis Factor-alpha, Interleukin-10, Interleukin-6 expression, function indicators (ALT, AST). Additionally, GPX4 knocked down transfection, molecular JDHY treating explored through blot, PCR, assay. Results appropriate dose D-GalN/LPS-induced (10 mg/mL μg/mL LPS 48 h) optimal (15%) ALT, AST, Kit-8 assays. treatment reduced ALT AST levels, alleviated inhibited ferroptosis. mechanism involves enhancing antioxidant capacity cells increasing regulating ferroptosis proteins (downregulating TfR1, upregulating FTH1), inhibiting LOX PTGS2, suppressing inflammation Factor-alpha Interleukin-6, Interleukin-10). In addition, knockdown experiments revealed that knocking worsened ALF, while can alleviate promoting cells. Conclusion enhance reduce peroxidation affected protecting cell, alleviating inflammatory,

Language: Английский

Advances in Ferroptosis Research: A Comprehensive Review of Mechanism Exploration, Drug Development, and Disease Treatment DOI Creative Commons
Haojie Wang, Yuanyuan Xie

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 334 - 334

Published: Feb. 26, 2025

In recent years, ferroptosis, as an emerging modality of programmed cell death, has captured significant attention within the scientific community. This comprehensive review meticulously canvasses pertinent literature past few spanning multiple facets. It delves into intricate mechanisms underpinning tracks evolution its inducers and inhibitors, dissects roles in a diverse array diseases, well resultant therapeutic implications. A profound exploration is conducted functional ferroptosis-related molecules, intracellular pathways, metabolic cascades, signaling transduction routes. Novel ferroptosis inhibitors are introduced detail, covering their design blueprints, synthetic methodologies, bioactivity profiles. Moreover, exhaustive account provided regarding involvement malignancies, neurodegenerative disorders, cardiovascular ailments, other pathologies. By highlighting pivotal status potential regimens various this aspires to furnish thorough reference framework for future investigations clinical translations domain.

Language: Английский

Citations

2
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

9
Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges DOI Creative Commons
Ahmed D. Alatawi, Krishnaraju Venkatesan,

Khalid A. Asseri

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 265 - 265

Published: Jan. 22, 2025

Ferroptosis, characterized by iron dependency and lipid peroxidation, has emerged as a key mechanism underlying neurodegeneration in rare neurological disorders. These conditions, often marked significant therapeutic gaps high unmet medical needs, present unique challenges for intervention development. This review examines the involvement of ferroptosis disease pathogenesis, focusing on its role oxidative damage neuronal dysfunction. We explore recent pharmacological advancements, including chelators, peroxidation blockers, antioxidant-based strategies, designed to target ferroptosis. While these approaches show promise, such heterogeneity, limited diagnostic tools, small patient cohorts hinder progress. Furthermore, we discuss translational regulatory barriers implementing ferroptosis-based therapies clinical practice. By addressing obstacles fostering innovative solutions, this underscores potential ferroptosis-targeting strategies revolutionize treatment paradigms

Language: Английский

Citations

1
Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment DOI Creative Commons

Nadi Rostami Ravari,

Farzad Sadri,

Mohammad Ali Mahdiabadi

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 26, 2025

Lung cancer (LC) is a highly prevalent and deadly type of characterized by intricate molecular pathways that drive tumor development, metastasis, resistance to conventional treatments. Recently, ferroptosis, controlled mechanism cell death instigated iron-dependent lipid peroxidation, has gained attention for its role in LC progression treatment. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) long noncoding (lncRNAs), are emerging key modulators significantly influencing biology. This review explores how ncRNAs control ferroptotic affect growth, therapy LC. By understanding the dual functions both activating inhibiting we aim uncover new therapeutic targets strategies These insights provide promising direction development ncRNA-based treatments designed induce potentially improving outcomes patients with

Language: Английский

Citations

1
Exploration of the Biological Function of Ferroptosis in Bone Nonunion: An Analysis of Bioinformatics Combined Mendelian Randomization DOI
Jun Yu, Kai Feng, Ming Yang

et al.

Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Language: Английский

Citations

0
Nano-XRF of lung fibrotic tissue reveals unexplored Ca, Zn, S and Fe metabolism: a novel approach to chronic lung diseases DOI Creative Commons
Bryan Falcones, Maik Kahnt, Ulf Johansson

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 7, 2025

Synchrotron-radiation nano-X-Ray Fluorescence (XRF) is a cutting-edge technique offering high-resolution insights into the elemental composition of biological tissues, shedding light on metabolic processes and element localization within cellular structures. In context Idiopathic Pulmonary Fibrosis (IPF), debilitating lung condition associated with respiratory complications reduced life expectancy, nano-XRF presents promising avenue for understanding disease's intricate pathology. Our developed workflow enables assessment in both human rodent fibrotic providing interplay between compartments chronic diseases. findings demonstrate trace accumulations anthracosis, feature observed IPF. Notably, Zn Ca clusters approximately 750 nm size were identified exclusively IPF samples. While their specific role remains unclear, presence may be disease-specific processes. Additionally, we Fe S signal colocalization 650-nm structures some cells. Fe-S complexes mitochondria are known to increased ROS production, suggesting potential connection disease contrast, bleomycin-induced fibrosis model exhibits different phenotype low S, Zn, Ca. Overall, our highlights effectiveness synchrotron-based mapping analyzing spatial distribution elements diseased tissue, valuable aspects related

Language: Английский

Citations

0
Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006 DOI
Yinyin Wang,

Yu-Song Wang,

Jun‐Jiang Li

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 158, P. 108342 - 108342

Published: March 6, 2025

Language: Английский

Citations

0
Research Progress of the Mechanism of Ferroptosis in Myocardial Ischemia-Reperfusion Injury DOI

嘉璐 赵

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 384 - 392

Published: Jan. 1, 2025

Language: Английский

Citations

0
Identification of Imidazo[1,2-a]pyridine-3-amine as a Novel Drug-like Scaffold for Efficious Ferroptosis Inhibition in vivo DOI
Jilei Wang,

Xuejing Fan,

Xinyu Han

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117516 - 117516

Published: March 1, 2025

Language: Английский

Citations

0
Natural flavonoids from herbs and nutraceuticals as ferroptosis inhibitors in central nervous system diseases: current preclinical evidence and future perspectives DOI Creative Commons

Qiuhe Li,

Xiaohang Yang, Tiegang Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

Flavonoids are a class of important polyphenolic compounds, renowned for their antioxidant properties. However, recent studies have uncovered an additional function these natural flavonoids: ability to inhibit ferroptosis. Ferroptosis is key mechanism driving cell death in central nervous system (CNS) diseases, including both acute injuries and chronic neurodegenerative disorders, characterized by iron overload-induced lipid peroxidation dysfunction the defense system. This review discusses therapeutic potential flavonoids from herbs nutraceuticals as ferroptosis inhibitors CNS focusing on molecular mechanisms, summarizing findings preclinical animal models, providing insights clinical translation. We specifically highlight such Baicalin, Baicalein, Chrysin, Vitexin, Galangin, Quercetin, Isoquercetin, Eriodictyol, Proanthocyanidin, (−)-epigallocatechin-3-gallate, Dihydromyricetin, Soybean Isoflavones, Calycosin, Icariside II, Safflower Yellow, which shown promising results models injuries, ischemic stroke, cerebral ischemia-reperfusion injury, intracerebral hemorrhage, subarachnoid traumatic brain spinal cord injury. Among these, Baicalin its precursor Baicalein stand out due extensive research favorable outcomes injury models. Mechanistically, not only regulate Nrf2/ARE pathway activate GPX4/GSH-related pathways but also modulate metabolism proteins, thereby alleviating overload inhibiting While show promise especially settings, further needed evaluate efficacy, safety, pharmacokinetics, blood-brain barrier penetration application.

Language: Английский

Citations

0