Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer’s Disease DOI Creative Commons
Melvin R. Hayden, Neetu Tyagi

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1741 - 1741

Опубликована: Дек. 23, 2024

Late-onset Alzheimer’s disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative that associates with aging highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for use sodium thiosulfate (STS) as possible multi-targeting treatment option LOAD. Sulfur widely available environment responsible forming organosulfur compounds are known to be associated wide range biological activities brain. STS have (i) antioxidant (ii) anti-inflammatory properties; (iii) chelation properties calcium pro-oxidative cation metals such iron copper; (iv) donor hydrogen sulfide production; (v) restorative brain endothelial-cell-derived bioavailable nitric oxide. Thus, it becomes apparent has potential neuroprotection neuromodulation may allow an attenuation nature neurodegeneration impaired cognition been successfully used prevent cisplatin oxidative-stress-induced ototoxicity head neck solid cancers, cyanide arsenic poisoning, fungal skin diseases. Most recently, intravenous become part plan calciphylaxis globally due vascular calcification ischemia-induced necrosis ulceration. Side effects minimal reports metabolic acidosis increased anion gap; any drug treatment, there also possibility allergic reactions, long-term osteoporosis from animal studies date, minor side-effects nausea, headache, rhinorrhea if infused too rapidly. While poorly penetrates intact blood–brain barrier(s) (BBBs), could readily penetrate BBBs dysfunctional disrupted deliver its neuroprotective neuromodulating addition ability blood–cerebrospinal fluid barrier choroid plexus. Novel strategies future nano-technology helpful allowing entry into

Язык: Английский

Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases DOI Creative Commons
Sehwan Kim, Un Ju Jung, Sang Ryong Kim

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1462 - 1462

Опубликована: Ноя. 28, 2024

Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s (AD). In these diseases, oxidative stress can disrupt blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, pathogens to enter brain, leading increased ROS production, mitochondrial dysfunction, inflammation. Collectively, factors result protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. this review article, we present mechanisms by which damage leads BBB breakdown brain diseases. Additionally, summarize potential therapeutic approaches aimed at reducing that contributes

Язык: Английский

Процитировано

10
Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia DOI Creative Commons
Yujie Yang, Chunchu Deng,

Fatima Aldali

и другие.

Cells, Год журнала: 2025, Номер 14(6), С. 409 - 409

Опубликована: Март 11, 2025

Small extracellular vesicles (sEVs), including exosomes as a subtype, with diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting diverse array bioactive molecules, proteins, nucleic acids, lipids, thereby facilitating intercellular communication modulating cellular functions. Vascular dementia (VaD) represents form cognitive impairment attributed to cerebrovascular disease, characterized by complex multifaceted pathophysiological mechanism. Currently, therapeutic approach VaD predominantly emphasizes symptom management, no specific pharmacological treatment exists cure condition. Recent investigations have illuminated significant role sEVs in pathogenesis vascular dementia. This review seeks provide comprehensive analysis characteristics functions sEVs, particular focus on their involvement its underlying mechanisms. The objective is advance understanding interplays between dementia, offering novel insights for future research strategies.

Язык: Английский

Процитировано

0
Redox modulatory role of DJ-1 in Parkinson’s disease DOI
Qamar A. Alshammari

Biogerontology, Год журнала: 2025, Номер 26(2)

Опубликована: Март 30, 2025

Язык: Английский

Процитировано

0
The Role of Oxidative Stress and Inflammation in the Pathogenesis and Treatment of Vascular Dementia DOI Creative Commons

Aseel Y. Altahrawi,

Antonisamy William James, Zahoor A. Shah

и другие.

Cells, Год журнала: 2025, Номер 14(8), С. 609 - 609

Опубликована: Апрель 17, 2025

Vascular dementia (VaD) is a heterogeneous group of brain disorders caused by cerebrovascular pathologies and the second most common cause dementia, accounting for over 20% cases posing an important global health concern. VaD can be cerebral infarction or injury in critical regions, including speech area dominant hemisphere arcuate fasciculus hemisphere, leading to notable cognitive impairment. Although exact causes remain multifactorial complex, oxidative stress (reactive oxygen species), neuroinflammation (TNFα, IL-6, IL-1β), inflammasomes are considered central mechanisms its pathology. These conditions contribute neuronal damage, synaptic dysfunction, decline. Thus, antioxidants anti-inflammatory agents have emerged as potential therapeutic targets dementia. Recent studies emphasize that disease plays dual role: first, primary impairment then contributor manifestation driven other factors, such Alzheimer’s neurodegenerative conditions. This comprehensive review focuses on molecular their consequences. We provided up-to-date knowledge about epidemiology, pathophysiological mechanisms, current approaches VaD.

Язык: Английский

Процитировано

0
Vascular Cognitive Impairment—The Molecular Basis and Potential Influence of the Gut Microbiota on the Pathological Process DOI Creative Commons
Piotr Olejnik, Aleksandra Golenia

Cells, Год журнала: 2024, Номер 13(23), С. 1962 - 1962

Опубликована: Ноя. 27, 2024

Cognitive impairment is a major healthcare challenge worldwide, with vascular cognitive (VCI) being its second leading cause after Alzheimer’s disease. VCI heterogeneous group of disorders resulting from various pathologies. Therefore, it particularly difficult to determine underlying and exact molecular basis. Nevertheless, the current understanding pathophysiological processes has changed evolved in last decades. The aim this narrative review summarize state knowledge on pathogenesis analyze potential role gut microbiota process, considering most recent scientific reports accordance these processes. Chronic cerebral hypoperfusion, which results impaired blood supply, i.e., oxygen nutrient deficiency, main mechanism VCI. Furthermore, chronic hypoperfusion triggers cascade changes, starting an energy imbalance, glutamate excitotoxicity, acidotoxicity, oxidative stress. Also, all above provoke activation microglia release pro-inflammatory cytokines that recruit systemic immune cells lead their infiltration into central nervous system, neuroinflammation. Blood–brain barrier dysfunction may occur at stages ultimately increasing permeability allowing potentially toxic substances enter brain parenchyma. Gut metabolites, have been identified numerous inflammatory conditions, also influence

Язык: Английский

Процитировано

2
Sulforaphane suppresses Aβ accumulation and tau hyperphosphorylation in vascular cognitive impairment(VCI) DOI
Cong Li, Lei Zhang, Xin Li

и другие.

The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер unknown, С. 109803 - 109803

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer’s Disease DOI Creative Commons
Melvin R. Hayden, Neetu Tyagi

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1741 - 1741

Опубликована: Дек. 23, 2024

Late-onset Alzheimer’s disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative that associates with aging highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for use sodium thiosulfate (STS) as possible multi-targeting treatment option LOAD. Sulfur widely available environment responsible forming organosulfur compounds are known to be associated wide range biological activities brain. STS have (i) antioxidant (ii) anti-inflammatory properties; (iii) chelation properties calcium pro-oxidative cation metals such iron copper; (iv) donor hydrogen sulfide production; (v) restorative brain endothelial-cell-derived bioavailable nitric oxide. Thus, it becomes apparent has potential neuroprotection neuromodulation may allow an attenuation nature neurodegeneration impaired cognition been successfully used prevent cisplatin oxidative-stress-induced ototoxicity head neck solid cancers, cyanide arsenic poisoning, fungal skin diseases. Most recently, intravenous become part plan calciphylaxis globally due vascular calcification ischemia-induced necrosis ulceration. Side effects minimal reports metabolic acidosis increased anion gap; any drug treatment, there also possibility allergic reactions, long-term osteoporosis from animal studies date, minor side-effects nausea, headache, rhinorrhea if infused too rapidly. While poorly penetrates intact blood–brain barrier(s) (BBBs), could readily penetrate BBBs dysfunctional disrupted deliver its neuroprotective neuromodulating addition ability blood–cerebrospinal fluid barrier choroid plexus. Novel strategies future nano-technology helpful allowing entry into

Язык: Английский

Процитировано

0