Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Язык: Английский
Molecular Psychiatry, Год журнала: 2022, Номер 27(4), С. 1920 - 1935
Опубликована: Фев. 22, 2022
Abstract The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects physiology has gained substantial attention in the field psychiatry. This is largely due to overlapping pathophysiological mechanisms associated with both potential functionality and biological thought be underpinning mental disorders. In this systematic review, we synthesised current literature investigating differences composition people major psychiatric disorders, depressive disorder (MDD), bipolar (BD) schizophrenia (SZ), compared ‘healthy’ controls. We also explored across disorders an attempt elucidate commonalities microbial signatures these Following PRISMA guidelines, databases were searched from inception through December 2021. identified 44 studies (including a total 2510 cases 2407 controls) that met inclusion criteria, which 24 investigated MDD, seven BD, 15 SZ. Our syntheses provide no strong evidence for difference number or distribution (α-diversity) bacteria those However, relatively consistent reporting overall community (β-diversity) without specific bacterial taxa commonly including lower levels genera produce short-chain fatty acids (e.g. butyrate), higher lactic acid-producing bacteria, glutamate GABA metabolism. observed heterogeneity regards methodologies reporting. Further prospective experimental research using new tools robust guidelines hold promise improving our role brain health development interventions based on modification microbiota.
Язык: Английский
Процитировано
318
Sleep Medicine Reviews, Год журнала: 2022, Номер 65, С. 101691 - 101691
Опубликована: Авг. 31, 2022
Язык: Английский
Процитировано
135
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4494 - 4494
Опубликована: Апрель 19, 2022
An emerging body of literature demonstrates differences in the gut microbiome (GMB) patients with major depressive disorder (MDD) compared to healthy controls (HC), as well potential benefits prebiotic, probiotic, and synbiotic treatment. We conducted a systematic review 24 observational studies (n = 2817), 19 interventional trials 1119). assessed alpha diversity, beta taxa abundance changes MDD relative HC, effect prebiotics, probiotics, synbiotics on symptoms individuals clinical or subclinical depression. observed no significant diversity but difference between HC. There were fluctuations specific Probiotic synbiotic, not treatment showed modest benefit reducing over four nine weeks. The GMB profiles differ significantly from further are needed elucidate probiotic treatments antidepressants longer follow-up before these therapies implemented into practice.
Язык: Английский
Процитировано
117
Metabolites, Год журнала: 2022, Номер 12(1), С. 50 - 50
Опубликована: Янв. 8, 2022
The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning of organism, affecting health disease status individuals. There continuous bidirectional communication between host, conforming to unique entity known as “holobiont”. Among these crosstalk mechanisms, synthesizes broad spectrum bioactive compounds or metabolites which exert pleiotropic effects on human organism. Many microbial can cross blood–brain barrier (BBB) have significant brain, playing key role in so-called microbiota-gut-brain axis. An altered (MGB) axis major characteristic many neuropsychiatric disorders, including depressive disorder (MDD). Significative differences eubiosis dysbiosis mental disorders like MDD with their different metabolite composition concentrations are being discussed. In present review, main (short-chain fatty acids -SCFAs-, bile acids, amino tryptophan -trp- derivatives, more), signaling pathways functions will be summarized explain part pathophysiology. Conclusions from promising translational approaches related metabolome addressed more depth discuss possible clinical value management patients.
Язык: Английский
Процитировано
86
Molecular Psychiatry, Год журнала: 2022, Номер 27(4), С. 1908 - 1919
Опубликована: Март 2, 2022
Язык: Английский
Процитировано
81
Frontiers in Neuroscience, Год журнала: 2022, Номер 15
Опубликована: Янв. 28, 2022
The microbiota-gut-brain axis, especially the inflammatory pathway, may play a critical role in pathogenesis of cognitive impairment major depressive disorder (MDD). However, studies on microbiota-inflammatory-cognitive function axis MDD are lacking. aim present study was to analyze gut microbiota composition and explore correlation between factors, patients.
Язык: Английский
Процитировано
53
Translational Psychiatry, Год журнала: 2023, Номер 13(1)
Опубликована: Дек. 8, 2023
Abstract Studies investigating gut microbiota composition in depressive disorder have yielded mixed results. The aim of our study was to compare microbiome between people with and healthy controls. We did a meta-analysis meta-regression studies by searching PubMed, Web Science, Embase, Scopus, Ovid, Cochrane Library, ProQuest, PsycINFO for articles published from database inception March 07, 2022. Search strategies were then re-run on 12 2023 an update. undertook meta-analyses whenever values alpha diversity Firmicutes, Bacteroidetes (relative abundance) available two or more studies. A random-effects model restricted maximum-likelihood estimator used synthesize the effect size (assessed standardized mean difference [SMD]) across identified 44 representing 2091 patients 2792 Our found that there no significant differences indices, Firmicutes compared In subgroup analyses regional variations(east/west) as predictor, who West had lower Chao1 level (SMD −0.42[−0.74 −0.10]). Subgroup showed decreased medication-free −1.54[−2.36 −0.72]), but increased −0.90[0.07 1.72]). analysis, six variables cannot explain 100% heterogeneity assessing Chao1, Shannon index, Bacteroidetes. Depleted levels Butyricicoccus, Coprococcus, Faecalibacterium, Fusicatenibacter, Romboutsia , enriched Eggerthella, Enterococcus, Flavonifractor, Holdemania, Streptococcus consistently shared disorder. This systematic review psychotropic medication dietary habit may influence microbiota. There is reliable evidence phylogenetic relationship controls, however, method measurement patient classification (symptom vs diagnosis based) affect findings. Depressive characterized increase pro-inflammatory bacteria, while anti-inflammatory butyrate-producing genera are depleted.
Язык: Английский
Процитировано
27
Neuropharmacology, Год журнала: 2021, Номер 197, С. 108721 - 108721
Опубликована: Июль 15, 2021
Язык: Английский
Процитировано
54
Microbiology Spectrum, Год журнала: 2023, Номер 11(3)
Опубликована: Апрель 12, 2023
Over the past decade, role of gut microbiota in many disease states has gained a great deal attention. Mounting evidence from case-control and observational studies linked changes to pathophysiology osteoporosis (OP). Nonetheless, results these contain discrepancies, leaving literature without consensus on osteoporosis-associated microbial signatures. Here, we conducted comprehensive meta-analysis combining reexamining five publicly available 16S rRNA partial sequence data sets identify bacteria consistently associated with across different cohorts. After adjusting for batch effect technical variation heterogeneity studies, observed significant shift composition group. An increase relative abundance opportunistic pathogens Clostridium sensu stricto, Bacteroides, Intestinibacter was OP Moreover, short-chain-fatty-acid (SCFA) producers, including members genera Collinsella, Megasphaera, Agathobaculum, Mediterraneibacter, XIV, Dorea, were depleted group healthy control (HC) Lactic acid-producing bacteria, Limosilactobacillus, significantly increased The random forest algorithm further confirmed that differentiate two groups. Furthermore, functional prediction revealed depletion SCFA biosynthesis pathway (glycolysis, tricarboxylic acid [TCA] cycle, Wood-Ljungdahl pathway) amino (methionine, histidine, arginine) HC This study uncovered OP-associated compositional alterations, providing robust insight into pathogenesis aiding possible development therapeutic intervention manage disease. IMPORTANCE Osteoporosis is most common metabolic bone aging. osteoporosis. However, which microbes are dysbiosis their impact density inflammation remain largely unknown due inconsistent literature. present standard workflow, statistical approaches, machine learning algorithms notable influencing
Язык: Английский
Процитировано
22
Translational Psychiatry, Год журнала: 2023, Номер 13(1)
Опубликована: Апрель 28, 2023
Abstract Alterations in the gut microbiome have been linked to a variety of mental illnesses including anxiety and depression. This study utilized advanced bioinformatics tools that integrated both compositional community nature microbiota investigate how influence clinical symptoms sample participants with Gut 179 major depressive disorder (MDD) Texas Resilience Against Depression (T-RAD) were analyzed by 16S rRNA gene sequencing stool samples. Severity anxiety, depression, anhedonia assessed General Anxiety Disorder – 7 item scale, Patient Health 9-item Questionnaire, Dimensional Anhedonia Rating Scale, respectively. Using weighted correlation network analysis, data-driven approach, three co-occurrence networks bacterial taxa identified. One these was significantly associated features depression anxiety. The hub this module –one Ruminococcaceae family taxon, one Clostridiales vadinBB60 group Christencenellaceae taxon– connected several additional butyrate-producing bacteria suggesting deficits butyrate production may contribute symptoms. Therefore, considering real world sample, identified microbial cohort depressed individuals.
Язык: Английский
Процитировано
19