Stress and cardiovascular disease: an update

Nature Reviews Cardiology, Год журнала: 2024, Номер 21(9), С. 603 - 616

Опубликована: Май 2, 2024

Язык: Английский

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Resilience And Successful Aging

The journal of nutrition health & aging, Год журнала: 2022, Номер 26(7), С. 652 - 656

Опубликована: Июнь 21, 2022

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What doesn’t kill us makes us stronger: insights from neuroscience studies and molecular genetics

Current Opinion in Behavioral Sciences, Год журнала: 2024, Номер 59, С. 101431 - 101431

Опубликована: Июль 22, 2024

Язык: Английский

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Mourning for Silence: Bereavement and Tinnitus—A Perspective

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2218 - 2218

Опубликована: Март 25, 2025

Tinnitus is defined as the conscious awareness of a tonal or composite noise for which there no identifiable corresponding external acoustic source, becomes tinnitus disorder when phantom sound associated with suffering and/or disability. There only limited knowledge about time course disorder. Bereavement science has identified four different trajectories: resilience, recovery, chronic, and delayed. The question arises whether these trajectories exist in well if one considers loss silence (at will). To verify exist, short-term progression was analyzed retrospectively using an Ecological Momentary Assessment (EMA) approach, extracting data from patients who started TrackYourTinnitus (TYT) app (version 1, Ulm University, 2013) start their perception. Four were via TYT acute tinnitus, bereavement reconstructed based on EMA. In conclusion, this perspective suggests that known may prospective evaluations larger samples are warranted to confirm disprove analogy between conceived (controllable) silence.

Язык: Английский

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Resilience by design: How nature, nurture, environment, and microbiome mitigate stress and allostatic load

World Journal of Psychiatry, Год журнала: 2023, Номер 13(5), С. 144 - 159

Опубликована: Май 19, 2023

Resilience to psychological stress is defined as adaption challenging life experiences and not the absence of adverse events. Determinants resilience include personality traits, genetic/epigenetic modifications genes involved in response, cognitive behavioral flexibility, secure attachment with a caregiver, social community support systems, nutrition exercise, alignment circadian rhythm natural light/dark cycle. Therefore, dynamic flexible process that continually evolves by intersection different domains human's life; biological, social, psychological. The objective this minireview summarize existing knowledge about multitude factors molecular alterations result from response. Given multiple contributing building resilience, we set out goal identify which were most supportive causal role current literature. We focused on resilience-related resulting mind-body homeostasis connection psychosocial environmental factors. conclude there no one factor differentiates resilient person vulnerable one. Instead, requires an intricate network positive healthy lifestyle contribute balanced connection. holistic approach must be adopted future research response address elements promote prevent illnesses psychopathology related allostatic load.

Язык: Английский

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Longitudinal Genome-Wide Study Reveals Genetic Architecture of Resilience Using a Novel Phenotype

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

The biological mechanisms underlying resilience have been extensively studied, yet our understanding of the genetic architecture in humans remains limited. While earlier studies investigated effects specific candidate genes, small sample sizes and narrow focus on one target gene provided a limited perspective architecture. Genome-wide association (GWAS) can overcome these issues but rarely applied to resilience. To date, only two GWAS are reported, because few sufficiently large-scale datasets measure resilience, those that do may not data. Here we used novel longitudinal phenotype with genomic data from Avon Longitudinal Study Parent Children (ALSPAC) establish trajectories response adverse childhood experiences (ACEs). Our results identify SMARCA2 OPRM1 genes as significant markers, highlighting their roles epigenetic dendritic functions associated Post-GWAS analyses revealed enrichment linked axonal functions, supporting hypothesis spine plasticity is crucial for cognitive approach offers functional insights into how across early life underpinned by factors, emphasising importance dynamic, phenotyping.

Язык: Английский

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Potential Biomarkers of Resilience to Microgravity Hazards in Astronauts

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Март 29, 2024

Space exploration exposes astronauts to the unique environment of microgravity, which poses significant health challenges. Identifying biomarkers that can predict an individual's resilience stressors microgravity holds great promise for optimizing astronaut selection and developing personalized countermeasures. This narrative review examines principal risks associated with explores potential indicative resilience. The being evaluated represent a broad spectrum physiological domains, including musculoskeletal, neurological, immunological, gastrointestinal, cardiovascular, cutaneous systems. Earth-based analogs, such as dry immersion head-down tilt bed rest, may provide valuable platforms validate candidate biomarkers. However, biomarker sensitivity specificity must be further ensure efficacy reliability. Establishing panel predictive microgravity-induced would significantly enhance mission success, especially long-duration missions. Insights gained also translate conditions on Earth characterized by reduced physical activity mechanical loading.

Язык: Английский

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A virtually supervised exercise program improved fitness and mental wellness in healthy and comorbidity older adult individuals during the COVID-19 pandemic

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Апрель 23, 2024

Background The COVID-19 pandemic affected older adults worldwide. Sedentary experienced more severe adverse health effects due to their shelter-in-place. Physical activity was strongly recommended during periods of social distancing. present study evaluated the impact a virtually supervised exercise program on physical fitness and mental Mexican pandemic’s lockdown. Methods Participants were 44 who assigned one four groups: healthy control group (Ctrl-H, n = 15), comorbidity (Ctrl-COM, 9), an without comorbidities (Exe-H, 11), with (Exe-COM, 9). participants engaged in 60-min, virtually-supervised concurrent session three times/week for 12 weeks. Fitness measured using online Senior Tests 4-m Gait Speed Test. Mental through virtual interviews Hamilton Depression Rating Scale, Geriatric Connor-Davidson Resilience Scale. Within-subject pre vs. post-intervention comparisons tested significant differences, between-groups over time. Results Significant interactions found scores Scale ( p ≤ 0.0001; η 2 0.35), resilience 0.46), lower-body strength 0.32), timed up-and-go test 0.018; 0.18), 6MWT distance 0.39), gait speed 0.011; 0.20). Conclusion A long-term conducted lockdown period led marked improvements both adults. Comorbidities did not diminish these benefits. These findings provide empirical support programs daily routines make clinically meaningful well-being.

Язык: Английский

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The role of resilience in the relationship between stress and alcohol

Neurobiology of Stress, Год журнала: 2024, Номер 31, С. 100644 - 100644

Опубликована: Май 16, 2024

Stress plays a well-documented role in alcohol consumption and the risk for developing use disorder. The concept of resilience - coping with successfully adapting to stressful life experiences has received increasing attention field addiction research recent decades, there been an accumulation evidence as protective factor against problematic consumption, disorder, disorder severity, relapse. conceptual methodological approaches used generation this vary considerably across investigations, however. In light this, we carried out review order provide more thorough understanding meaning scope resilience, what factors contribute how it is measured, relates alcohol-associated phenotypes. Implications treatment through resilience-building interventions are likewise discussed, well implications future on etiology clinical outcomes

Язык: Английский

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Increased Lactobacillus Abundance Contributes to Stress Resilience in Mice Exposed to Chronic Social Defeat Stress

Neuroendocrinology, Год журнала: 2022, Номер 113(5), С. 563 - 576

Опубликована: Дек. 30, 2022

Accumulating evidence indicates that abnormalities in the composition of gastrointestinal (GI) microbiota play a vital role stress-related disorders. Both human beings and animals perceive stressful events differently, i.e., resilience or susceptibility. However, GI stress resilience/susceptibility underlying mechanisms remain largely unknown.Sixty male C57BL/6J mice were exposed to 10-day chronic social defeat (CSDS), 28 found be resilient CSDS. We next analyzed compositions cecum using 16S rDNA gene sequencing, which revealed significant increase relative abundance Lactobacillus at genus level mice. In subsequent experiments, we oral administration strain (Lactobacillus murinus) for 2 weeks attenuated increased levels stress-induced corticosterone anxiety-like behavior stress-susceptible The mRNA expression tryptophan hydroxylase (a rate-limiting enzyme serotonin [5-HT] synthesis) was also significantly dorsal raphe nucleus (DR) mice.Lactobacillus contributes resilience, DR 5-HT system may an important during this process. above results suggest certain organisms tract essential response useful prevention treatment some psychiatric disorders, such as depression.

Язык: Английский

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