PubMed, Год журнала: 2023, Номер 48(6), С. 852 - 858
Опубликована: Июнь 28, 2023
With the increase in aging population China, elderly Crohn's disease (CD) patients need to receive more attention. This study aims explore clinical characteristics and process of onset CD (EOCD) a single center.
Язык: Английский
Journal of Epidemiology and Global Health, Год журнала: 2023, Номер 13(4), С. 725 - 739
Опубликована: Сен. 1, 2023
Asia's inflammatory bowel disease (IBD) burden has rapidly increased recently, but the epidemiological trends in Asia remain unclear. We report IBD's incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALY) 52 Asian countries from 1990 to 2019.Data Global Burden of Disease 2019 were analyzed for IBD across countries, using metrics like mortality rates, DALY. The trend was assessed with Joinpoint APC methods. Decomposition frontier analyses examined factors behind case death changes. NORPRED forecasted morbidity 2044.From 2019, incidence prevalence Asia, while DALY decreased. East had highest increase burden. among 30-34 age group, peaking 45-49 group. In high-income regions, peak shifted younger groups. Decompose analysis showed population growth as primary factor increasing cases Asia. NORDPRED model predicted a continued over next 25 years.Between ASIR ASPR increased, ASMR ASDR Due aging, is expected rise years, particularly
Язык: Английский
Процитировано
29
Precision Clinical Medicine, Год журнала: 2024, Номер 7(1)
Опубликована: Янв. 8, 2024
Abstract Inflammatory bowel diseases (IBD), with an increasing incidence, pose a significant health burden. Although there have been advances in the treatment of IBD, more progress is still needed. Hyperbaric oxygen therapy (HBOT) has shown to treat host conditions such as carbon monoxide poisoning, decompression sickness, and gas gangrene. In last few years, increase research into use HBOT adjunct conventional for IBD. Related that may exert its therapeutic effects by decreasing oxidative stress, inhibiting mucosal inflammation, promoting ulcer healing, influencing gut microbes, reducing incidence IBD complications. This paper aims provide comprehensive review experimental clinical trials exploring supplement strategies.
Язык: Английский
Процитировано
12
Chinese Medical Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Abstract Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a chronic inflammation of the gastrointestinal tract with unknown etiology. The cause IBD widely considered multifactorial, prevailing hypotheses suggesting that microbiome various environmental factors contribute to inappropriate activation mucosal immune system in genetically susceptible individuals. Although incidence has stabilized Western countries, it rapidly increasing newly industrialized particularly China, making global disease. Significant changes multiple biomarkers before diagnosis during preclinical phase provide opportunities for earlier intervention. Advances technology have driven development telemonitoring tools, such as home-testing kits fecal calprotectin, serum cytokines, therapeutic drug concentrations, well wearable devices testing sweat cytokines heart rate variability. These tools enable real-time activity assessment timely treatment strategy adjustments. A wide range novel drugs IBD, interleukin-23 inhibitors (mirikizumab, risankizumab, guselkumab) small-molecule (etrasimod upadacitinib), been introduced past few years. Despite these advancements, approximately one-third patients remain primary non-responders initial treatment, half eventually lose response over time. Precision medicine integrating multi-omics data, advanced combination therapy, complementary approaches, stem cell transplantation, psychological therapies, neuromodulation, gut modulation may offer solutions break through ceiling.
Язык: Английский
Процитировано
2
Clinics and Research in Hepatology and Gastroenterology, Год журнала: 2025, Номер unknown, С. 102591 - 102591
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
Clinical Epidemiology, Год журнала: 2023, Номер Volume 15, С. 151 - 163
Опубликована: Фев. 1, 2023
Understanding the temporal trends in epidemiology of colorectal cancer (CRC) and early-onset CRC (EOCRC) China is essential for policymakers to develop appropriate strategies reduce burden.The prevalence, incidence, mortality, years life lived with disability (YLDs), lost (YLLs), disability-adjusted (DALYs) were obtained from Global Burden Disease (GBD) Study 2019. The incidence mortality over next 25 predicted.From 1990 2019, total EOCRC significantly increased males, milder females. In number people living (or EOCRC) was approximately 3.4 (0.59) million, which seven (five) times higher than that 1990. DALYs, YLDs, YLLs moderately 2019 both sexes. age-standardized rate (ASMR) females has shown a stable trend CRC, downward since 2000. While ASMR males showed increasing EOCRC. highest YLLs, DALYs all observed 65 69 age group, while 70 74. By 2044, deaths are expected reach 1310 thousand 484 thousand, respectively. For EOCRC, will peak at about 101 around 2034, continuously decrease nadir 18 2044.Although plateau, incident cases have been last three decades continue increase years.
Язык: Английский
Процитировано
23
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 9, 2024
Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic molecular interactions. The Hippo signaling pathway plays a crucial role in regulating cell processes is implicated the pathogenesis of IBD CRC. Circular RNAs (circRNAs) have gained attention for roles various diseases, including However, comprehensive understanding specific circRNAs involved CRC, functional lacking. Here, it found that circHIPK2 (hsa_circRNA_104507) bona fide circRNA consistently upregulated CRC suggesting its potential as biomarker. Furthermore, silencing suppressed growth cells vitro vivo. Interestingly, decreased circHipk2 potentiated dextran sulfate sodium (DSS)-induced colitis but alleviated colitis-associated tumorigenesis. Most significantly, mechanistic investigations further unveil circHIPK2, mediated by FUS, interacting with EIF4A3 to promote translation TAZ, ultimately increasing transcription downstream target genes CCN1 CCN2. Taken together, emerges key player shared mechanisms modulating pathway. CircHIPK2-EIF4A3 axis contributes intestinal epithelial enhancing TAZ translation.
Язык: Английский
Процитировано
9
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Фев. 23, 2023
Inflammatory bowel disease (IBD) can progress into colitis-associated colorectal cancer (CAC) through the inflammation-cancer sequence. Although mechanism of carcinogenesis in IBD has not been fully elucidated, existing research indicates that CAC may represent a fundamentally different pathogenesis pattern cancer. At present, there is no proven safe and effective medication to prevent In recent years, Chinese medicine extracts monomers have subject numerous articles about prevention treatment CAC, but their clinical application still relatively limited. Traditional Medicine (TCM) formulas are widely applied practice. TCM demonstrated great potential although lack review. Our work aimed summarize effects mechanisms for point out issues limitations current research, provide recommendations advancement future. We discovered regulated many malignant biological processes, such as inflammation-mediated oxidative stress, apoptosis, tumor microenvironment, intestinal microecology imbalance review published databases
Язык: Английский
Процитировано
14
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Март 25, 2024
The escalation of urbanization correlates with rising rates inflammatory bowel disease (IBD), necessitating research into new etiological factors. This study aims to elucidate the gut microbiota profiles in IBD patients and compare them healthy controls a western city China. We conducted multicenter case-control from end 2020, using 16S rRNA gene sequencing (n = 36) metagenomic 12) analyze newly diagnosed patients, including those Crohn's (CD) ulcerative colitis (UC). Our results demonstrated significant enrichment phylum Proteobacteria, particularly genus Escherichia-Shigella, CD patients. Conversely, Enterococcus was markedly increased UC core microbiota, such as Christensenellaceae R-7 group, Fusicatenibacter, Holdemanella, were primarily identified subjects. Additionally, interactions between microbiome virulence factors observed. findings suggest that oxidative stress may play pivotal role pathology IBD. contributes growing dialogue about impact on development its variations across different geographies, highlighting potential avenues for further research.
Язык: Английский
Процитировано
6
Chinese Medical Journal, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 6, 2024
Abstract Background: Inflammatory bowel disease (IBD) imposes a significant economic and social burden in China. We aim to assess the epidemiological trends of IBD China, predict near future. Methods: The incidence, mortality, prevalence, disability-adjusted life year (DALYs) from 1990 2021 were obtained Global Burden Disease 2021. Estimated annual percentage change (EAPC), average percent change, total age-period-cohort model used access trends. Bayesian age–period–cohort was utilized risk incidence mortality. Results: In 2021, affected 168,077 people with 24,941 new cases 5640 deaths. age-standardized rate (ASR) death 1.4 0.3, respectively. prevalence China lower than global high socio-demographic index (SDI) regions, but ASR (EAPC: 2.93 2.54, respectively) had rapidly increased DALYs significantly decreased −3.05 −2.93, respectively). Middle-aged elderly populations faced severe while population mortality burden. It is projected that by 2035, will continue rise, whereas decline. Conclusions: serious increasingly severe. Establishing comprehensive management system help better control medical IBD.
Язык: Английский
Процитировано
5
Psychology Research and Behavior Management, Год журнала: 2024, Номер Volume 17, С. 219 - 235
Опубликована: Янв. 1, 2024
Purpose: To identify the distinct profiles of psychosocial adaptation Chinese inflammatory bowel disease (IBD) patients and predictive factors. Patients Methods: A cross-sectional survey method was used to recruit 263 IBD who were treated in a tertiary hospital Shandong Province from July 2022 April 2023. The general information questionnaire, Inflammatory Bowel Disease Psychosocial Adaptation Questionnaire, Resilience Scale for Disease, Benefit Finding Scale, Stigma Chronic Illnesses, Medical Coping Modes Questionnaire Disease-Disk as instruments investigation. Latent profile analysis conducted with six dimensions explicit indicators. predictors membership analyzed by multinomial logistic regressions. Results: Four identified: Low level (14.1%), Medium – High body image distress (25.5%), (30.0%) (30.4%). Compared group, group had higher positive cognition (OR=2.930, 95%IC 0.017– 0.305, p < 0.001) overall psychological resilience ( OR =1.832, 0.000– 0.016, 0.001), more health behaviors = 2.520, 0.191– 1.358, =0.001), lower internal stigma =0.135, 0.043– 0.420, =0.010, 0.003– 0.118, less acceptance-resignation coping style =0.055, 0.209– 3.200, burden =0.407, 0.298– 0.698, =0.006). Conclusion: About half medium adaptation. Psychological resilience, benefit finding, stigma, medical styles predicted profiles. Healthcare providers need focus on heterogeneity formulate personalized intervention programs different improve their Keywords: disease, latent analysis, adaptation, coping,
Язык: Английский
Процитировано
4