Editorial: A Toxic Aging Coin perspective to investigate the intersection of toxicology and aging DOI Creative Commons
Rachel M. Wise, John Pierce Wise, Julie K. Andersen

и другие.

Frontiers in Toxicology, Год журнала: 2024, Номер 6

Опубликована: Дек. 12, 2024

The intersection between toxicology and aging is a compelling yet often overlooked topic. 1 Our society imminently challenged with growing numbers of individuals across the globe as lifespans continue to lengthen these geriatric populations increasing at an unprecedented rate. 2,3 Compounding this global challenge, understanding contribution environmental toxicants presents critical two-sided dilemma that we have designated 'Toxic Aging Coin'. On heads side consider how age impacts effects toxic chemicals, while on tails chemicals exacerbate or accelerate outcomes. This volume compiles manuscripts timely topic exploring dual nature coin, one representing natural progression life changing stages other considering detrimental exposure can complicate journey.Aging universal experience major risk factor for several neurodegenerative diseases, including Parkinson's disease Alzheimer's disease. characterized by gradual diminution physiological processes impairs ability reinforce internal homeostasis, results in increased vulnerability disease, infections, trauma, stress. process driven genetic, environmental, lifestyle factors; though influence genes lifespan variation estimated be less than 10%, leaving majority influences factors. 4 biological mechanisms underlying aging, such telomere shortening, mitochondrial dysfunction, cellular senescence, are well-documented. However, role substances modulating has been scantly characterized. To address concerns impact interdisciplinary research essential. Here, manuscripts/reviews attempt highlight interaction toxicology. Scieszka et al. approached concept through lens wildfire smoke air quality processes. 5 authors review key hallmarks, attrition inhaled from wildfires may Preliminary findings suggest neurological impair learning disrupting vascular integrity promoting neuroinflammation. stresses importance studying relationship exposures inform future interventions, well potential using anti-inflammatory NAD+ boosting compounds intervention strategies.An original article Tsai reported acute intoxication organophosphate (OP) cholinesterase inhibitors lead cholinergic crisis, resulting severe symptoms respiratory depression seizures health issues evolve into further 6 Those who survive long-term behavioral deficits, but connecting OP chronic remain unclear. tested hypothesis induces senescence brain rat model exposed diisopropylfluorophosphate (DFP). While no signs were found one-month post-exposure, significant increases biomarker p16 observed three six months, specifically neurons within certain regions, suggesting mechanism deficits survivors intoxication.A Ottinger focuses integrating Toxic Coin One Health frameworks. 7 begin introducing framework, which observes wildlife, ecosystems, humans interconnected, emphasizing wildlife preservation essential maintaining healthy ecosystems. They use examples sharp declines avian over last century due human activities like industrialization, habitat loss, climate change led stress both wildlife. then present "Toxic Coin", suggests stressors not only also affect older individuals' cope pollutants. discuss concepts merged explore important connections propose strategies improving outcomes alike.Finally, mini review, Ratner Rutchik copper function, highlighting deficiencies excesses adverse 8 case study 53-year-old woman early onset Lewy Body Dementia Parkinsonism revealing contamination her drinking water, contributed condition. α-synucleinopathies should avoid excessive exposure, similar recommendations those disease.For future, recommend together, toxicologists gerontologists collaborate investigate metabolism agents. It imperative studies cumulative throughout public policies regulations. In studies, hope will encourage policymakers better recognize implications advocate more comprehensive initiatives.

Язык: Английский

Among Gerontogens, Heavy Metals Are a Class of Their Own: A Review of the Evidence for Cellular Senescence DOI Creative Commons

Samuel T. Vielee,

John Pierce Wise

Brain Sciences, Год журнала: 2023, Номер 13(3), С. 500 - 500

Опубликована: Март 16, 2023

Advancements in modern medicine have improved the quality of life across globe and increased average lifespan our population by multiple decades. Current estimates predict 2030, 12% global will reach a geriatric age live another 3-4 This swelling place critical stress on healthcare infrastructures due to accompanying increases age-related diseases comorbidities. While much research focused long-lived individuals seeks answer questions regarding how healthier, there is deficit investigating what aspects lives accelerate or exacerbate aging. In particular, heavy metals are recognized as significant threat human health with links plethora diseases, widespread exposures from occupational, medical, environmental settings. We believe ought be classified class gerontogens (i.e., chemicals that biological aging cells tissues). Gerontogens may best studied through their effects "Hallmarks Aging", nine physiological hallmarks demonstrated occur aged cells, tissues, bodies. Evidence suggests cellular senescence-a permanent growth arrest cells-is one most pertinent useful indicator tissues. Here, we discuss roles brain briefly general, then expand upon observations for contributing neurodegenerative disorders. particularly emphasize senescence diseases. Finally, inducing senescence. The glaring lack knowledge about gerontogenic mechanisms necessitates greater field, especially context crisis.

Язык: Английский

Процитировано

15
Employing a Toxic Aging Coin approach to assess hexavalent chromium (Cr[VI])-induced neurotoxic effects on behavior: Heads for age differences DOI

Samuel T. Vielee,

Jessica Isibor,

William J. Buchanan

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 489, С. 117007 - 117007

Опубликована: Июнь 18, 2024

Язык: Английский

Процитировано

5
Female Rat Behavior Effects from Low Levels of Hexavalent Chromium (Cr[VI]) in Drinking Water Evaluated with a Toxic Aging Coin Approach DOI Creative Commons

Samuel T. Vielee,

Jessica Isibor,

William J. Buchanan

и другие.

Applied Sciences, Год журнала: 2024, Номер 14(14), С. 6206 - 6206

Опубликована: Июль 17, 2024

We are facing a critical aging crisis, with geriatric populations (65+) growing to unprecedented proportions and ~4 million people (a 6.5-fold increase) expected become centenarians by 2050. This is compounded environmental pollution, which affects individuals of all ages contributes age-related diseases. As we have limited understanding how pollutants affect older distinctly from younger populations, these longer-lived present key knowledge gap. To address this gap, employ “Toxic Aging Coin” approach: heads consider age impacts chemical toxicity, tails chemicals act as gerontogens—or they accelerate biological aging. employed approach investigate hexavalent chromium (Cr[VI]) on female rats exposed 0.05 or 0.1 mg Cr(VI)/L in drinking water for 90 days; the maximum contaminant levels (i.e., highest permitted) World Health Organization U.S. Environmental Protection Agency, respectively. During exposure, performed battery behavior assays assess grip strength, locomotor coordination, anxiety, spatial memory, sociability, social novelty preference. observed differences Cr(VI) neurotoxicity, function, memory middle-aged females being particularly affected. further compared results males, noting many sex differences, especially rats. These data emphasize need variables toxicology revisit regulations Cr(VI).

Язык: Английский

Процитировано

2
Chromium Selectively Accumulates in the Rat Hippocampus after 90 Days of Exposure to Cr(VI) in Drinking Water and Induces Age- and Sex-Dependent Metal Dyshomeostasis DOI Creative Commons

Samuel T. Vielee,

William J. Buchanan,

Spencer H. Roof

и другие.

Toxics, Год журнала: 2024, Номер 12(10), С. 722 - 722

Опубликована: Окт. 3, 2024

Hexavalent chromium (Cr[VI]) is a widespread environmental pollutant in air and water that primarily attributed to industrial pollution. The current maximum contaminant levels (MCLs) for drinking from the World Health Organization U.S. Environmental Protection Agency (0.05 0.1 mg/L, respectively) were set based on contact dermatitis warrant further toxicological investigation. While Cr(VI) neurotoxic accumulates brain, most animal studies only report whole-brain Cr, leaving large knowledge gaps. Few consider differences between ages or sexes, fewer essential metal dyshomeostasis. We sought investigate where Cr considering sex age differences, following 90-day exposure MCLs. Here, we six brain regions of rats exposed Cr(VI). observed accumulated hippocampus, older females. assessed changes metals observing opposite effects across sexes young compared rats. In sum, our data indicate selectively targeted with geriatric females accumulating induced significant dyshomeostasis even tissues lacking evident accumulation.

Язык: Английский

Процитировано

1
Reproductive toxicology: keeping up with our changing world DOI Creative Commons

Laura B. Miller,

Morgan B. Feuz,

Ralph G. Meyer

и другие.

Frontiers in Toxicology, Год журнала: 2024, Номер 6

Опубликована: Окт. 11, 2024

Reproductive toxicology testing is essential to safeguard public health of current and future generations. Traditional toxicological male reproduction has focused on evaluating substances for acute toxicity the reproductive system, with fertility assessment as a main endpoint infertility adverse outcome. Newer studies in last few decades have significantly widened our understanding what represents an event toxicology, thus changed perspective constitutes toxicant, such endocrine disrupting chemicals that affect offspring intergenerational manner. Besides or congenital abnormalities, outcomes can present increased likelihood various problems offspring, including metabolic syndrome, neurodevelopmental like autism cancer predisposition, among others. To enable toxicologic accurately represent population, designs need model changing population characteristics exposure circumstances. Current trends increasing importance human include paternal age, associated decline nicotinamide adenine dinucleotide (NAD), higher prevalence obesity, both which are factors study design should account for. In this article, we highlighted some limitations standard protocols, expanding assessed by genetic epigenetic sperm parameters, potential recent developments, mixture testing, novel animal models, vitro systems organoids, multigenerational well silico modelling, machine learning artificial intelligence.

Язык: Английский

Процитировано

0
Editorial: A Toxic Aging Coin perspective to investigate the intersection of toxicology and aging DOI Creative Commons
Rachel M. Wise, John Pierce Wise, Julie K. Andersen

и другие.

Frontiers in Toxicology, Год журнала: 2024, Номер 6

Опубликована: Дек. 12, 2024

The intersection between toxicology and aging is a compelling yet often overlooked topic. 1 Our society imminently challenged with growing numbers of individuals across the globe as lifespans continue to lengthen these geriatric populations increasing at an unprecedented rate. 2,3 Compounding this global challenge, understanding contribution environmental toxicants presents critical two-sided dilemma that we have designated 'Toxic Aging Coin'. On heads side consider how age impacts effects toxic chemicals, while on tails chemicals exacerbate or accelerate outcomes. This volume compiles manuscripts timely topic exploring dual nature coin, one representing natural progression life changing stages other considering detrimental exposure can complicate journey.Aging universal experience major risk factor for several neurodegenerative diseases, including Parkinson's disease Alzheimer's disease. characterized by gradual diminution physiological processes impairs ability reinforce internal homeostasis, results in increased vulnerability disease, infections, trauma, stress. process driven genetic, environmental, lifestyle factors; though influence genes lifespan variation estimated be less than 10%, leaving majority influences factors. 4 biological mechanisms underlying aging, such telomere shortening, mitochondrial dysfunction, cellular senescence, are well-documented. However, role substances modulating has been scantly characterized. To address concerns impact interdisciplinary research essential. Here, manuscripts/reviews attempt highlight interaction toxicology. Scieszka et al. approached concept through lens wildfire smoke air quality processes. 5 authors review key hallmarks, attrition inhaled from wildfires may Preliminary findings suggest neurological impair learning disrupting vascular integrity promoting neuroinflammation. stresses importance studying relationship exposures inform future interventions, well potential using anti-inflammatory NAD+ boosting compounds intervention strategies.An original article Tsai reported acute intoxication organophosphate (OP) cholinesterase inhibitors lead cholinergic crisis, resulting severe symptoms respiratory depression seizures health issues evolve into further 6 Those who survive long-term behavioral deficits, but connecting OP chronic remain unclear. tested hypothesis induces senescence brain rat model exposed diisopropylfluorophosphate (DFP). While no signs were found one-month post-exposure, significant increases biomarker p16 observed three six months, specifically neurons within certain regions, suggesting mechanism deficits survivors intoxication.A Ottinger focuses integrating Toxic Coin One Health frameworks. 7 begin introducing framework, which observes wildlife, ecosystems, humans interconnected, emphasizing wildlife preservation essential maintaining healthy ecosystems. They use examples sharp declines avian over last century due human activities like industrialization, habitat loss, climate change led stress both wildlife. then present "Toxic Coin", suggests stressors not only also affect older individuals' cope pollutants. discuss concepts merged explore important connections propose strategies improving outcomes alike.Finally, mini review, Ratner Rutchik copper function, highlighting deficiencies excesses adverse 8 case study 53-year-old woman early onset Lewy Body Dementia Parkinsonism revealing contamination her drinking water, contributed condition. α-synucleinopathies should avoid excessive exposure, similar recommendations those disease.For future, recommend together, toxicologists gerontologists collaborate investigate metabolism agents. It imperative studies cumulative throughout public policies regulations. In studies, hope will encourage policymakers better recognize implications advocate more comprehensive initiatives.

Язык: Английский

Процитировано

0