European journal of ecology, biology and agriculture.,
Год журнала:
2024,
Номер
1(5), С. 29 - 48
Опубликована: Ноя. 1, 2024
Staphylococcus
aureus
is
a
major
human
pathogen
responsible
for
wide
range
of
infections,
from
mild
skin
conditions
to
severe
systemic
diseases.
The
increasing
prevalence
antibiotic-resistant
strains,
such
as
methicillin-resistant
S.
(MRSA),
poses
significant
challenges
global
healthcare
systems.
This
review
provides
comprehensive
analysis
the
genomic
mechanisms
underpinning
antibiotic
resistance
and
virulence
in
aureus.
Key
include
acquisition
genes
through
horizontal
gene
transfer,
mutations
target
sites,
overexpression
efflux
pumps.
Additionally,
regulation
factors,
toxins,
adhesion
molecules,
enzymes,
controlled
by
complex
genetic
networks,
including
quorum
sensing
regulators
like
agr
sar
Advances
whole-genome
sequencing
have
facilitated
deeper
understanding
diversity
adaptability
These
insights
are
essential
developing
innovative
therapeutic
strategies
mitigating
impact
this
on
public
health.
Computational and Structural Biotechnology Journal,
Год журнала:
2025,
Номер
27, С. 423 - 439
Опубликована: Янв. 1, 2025
Antimicrobial
resistance
(AMR)
is
a
major
threat
to
global
public
health.
The
current
review
synthesizes
address
the
possible
role
of
Artificial
Intelligence
and
Machine
Learning
(AI/ML)
in
mitigating
AMR.
Supervised
learning,
unsupervised
deep
reinforcement
natural
language
processing
are
some
main
tools
used
this
domain.
AI/ML
models
can
use
various
data
sources,
such
as
clinical
information,
genomic
sequences,
microbiome
insights,
epidemiological
for
predicting
AMR
outbreaks.
Although
relatively
new
fields,
numerous
case
studies
offer
substantial
evidence
their
successful
application
outbreaks
with
greater
accuracy.
These
provide
insights
into
discovery
novel
antimicrobials,
repurposing
existing
drugs,
combination
therapy
through
analysis
molecular
structures.
In
addition,
AI-based
decision
support
systems
real-time
guide
healthcare
professionals
improve
prescribing
antibiotics.
also
outlines
how
AI
surveillance,
analyze
trends,
enable
early
outbreak
identification.
Challenges,
ethical
considerations,
privacy,
model
biases
exist,
however,
continuous
development
methodologies
enables
play
significant
combating
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июль 11, 2024
Abstract
Genomic
surveillance
(GS)
programmes
were
crucial
in
identifying
and
quantifying
the
mutating
patterns
of
SARS-CoV-2
during
COVID-19
pandemic.
In
this
work,
we
develop
a
Bayesian
framework
to
quantify
relative
transmissibility
different
variants
tailored
for
regions
with
limited
GS.
We
use
it
study
Chile.
Among
3443
genomes
collected
between
January
June
2021,
where
sampling
was
designed
be
representative,
Gamma
(P.1),
Lambda
(C.37),
Alpha
(B.1.1.7),
B.1.1.348,
B.1.1
lineages
predominant.
found
that
variants’
reproduction
numbers
5%
(95%
CI:
[1%,
14%])
16%
[11%,
21%])
larger
than
Alpha’s,
respectively.
Besides,
observed
systematic
mutation
enrichment
Spike
gene
all
circulating
variants,
which
strongly
correlated
studied
period
(r
=
0.93,
p-value
0.025).
also
characterised
mutational
signatures
local
samples
their
evolution
over
time
progress
vaccination,
comparing
them
those
other
worldwide.
Altogether,
our
work
provides
reliable
method
variant
under
subsampling
emphasises
importance
continuous
genomic
surveillance.
One Health,
Год журнала:
2025,
Номер
20, С. 100966 - 100966
Опубликована: Янв. 5, 2025
The
concept
of
One
Health
was
developed
as
a
successful
strategy
for
addressing
global
crises
that
impact
the
health
animals,
humans,
and
plants.
agriculture
industry
is
facing
huge
dilemma
due
to
climate
change
impacts
heat
stress,
which
might
pose
threat
mankind
in
future.
In
order
enhance
management
stress
sector
(Agri-heat
stress),
we
suggest
implementing
approach.
This
because
existing
methods
employed
alleviate
both
livestock
crop
farming
may
have
side-effects
on
well-being
plants,
ecosystem.
review
article
examines
"dilemma"
mitigating
animal
husbandry.
It
discusses
approach
including
recommended
reducing
Agri-heat
using
study
also
highlights
benefits
adopting
stress.
our
opinion,
efficacy
Approach
depends
process
conceptualization.
includes
recognizing
issue
or
hypothesis,
well
incorporating
cooperating
teams
creation
environmentally
friendly
approaches.
challenges
this
notion
arise
from
precise
coordination
resources
collaborators.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1263 - 1263
Опубликована: Янв. 31, 2025
The
emergence
of
SARS-CoV-2
variants
has
significantly
impacted
the
global
response
to
COVID-19
pandemic.
This
review
examines
genetic
diversity
variants,
their
roles
in
epidemiological
tracking,
and
influence
on
viral
fitness.
Variants
concern
(VOCs)
such
as
Alpha,
Beta,
Gamma,
Delta,
Omicron
have
demonstrated
increased
transmissibility,
altered
pathogenicity,
potential
resistance
neutralizing
antibodies.
Epidemiological
tracking
these
is
crucial
for
understanding
spread,
informing
public
health
interventions,
guiding
vaccine
development.
also
explores
how
specific
mutations
spike
protein
other
genomic
regions
contribute
fitness,
affecting
replication
efficiency,
immune
escape,
transmission
dynamics.
By
integrating
surveillance
data
with
clinical
findings,
this
provides
a
comprehensive
overview
ongoing
evolution
its
implications
strategies
new
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 17, 2025
As
part
of
a
multi-state
viral
genomic
surveillance
program,
we
conducted
case-only
analysis
to
evaluate
the
effectiveness
XBB.1.5-adapated
mRNA
vaccines
in
preventing
severe
illness
among
individuals
with
medically
attended
SARS-CoV-2
infection.
We
compared
prior
receipt
an
XBB.1.5-adapted
vaccine
between
SARS-CoV-2-infected
adults
inpatient
or
emergency
department
(ED)
visits
(as
proxy
for
illness)
vs
those
outpatient
mild
illness).
Among
6,551
patients
September
2023
and
January
2024,
6.1%
ED
12.0%
had
received
XBB.1.5
vaccination
(adjusted
odds
ratio
[aOR]=0.41;
95%
confidence
interval
[CI]:
0.32-0.53).
This
protective
association
was
weaker
JN.1
(aOR=0.62;
CI:
0.40-0.96)
XBB-lineage
(aOR=0.28;
0.18-0.43)
variant
infections
(interaction,
p=0.003).
protect
against
illness,
but
protection
may
be
variants.
study
highlights
need
COVID-19
routinely
updated
align
circulating
strains
stay
up
date
recommended
vaccines.
Interdisciplinary Perspectives on Infectious Diseases,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
This
paper
explores
the
transformative
potential
of
integrating
artificial
intelligence
(AI)
in
diagnosis
and
prognosis
infectious
diseases.
By
analyzing
diverse
datasets,
including
clinical
symptoms,
laboratory
results,
imaging
data,
AI
algorithms
can
significantly
enhance
early
detection
personalized
treatment
strategies.
reviews
how
AI-driven
models
improve
diagnostic
accuracy,
predict
patient
outcomes,
contribute
to
effective
disease
management.
It
also
addresses
challenges
ethical
considerations
associated
with
AI,
data
privacy,
algorithmic
bias,
equitable
access
healthcare.
Highlighting
case
studies
recent
advancements,
underscores
AI's
role
revolutionizing
management
its
implications
for
future
healthcare
delivery.
