Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 Infectivity

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(5), С. 2643 - 2643

Опубликована: Фев. 27, 2022

The overall impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on our society is unprecedented. identification small natural ligands that could prevent the entry and/or replication remains a pertinent approach to fight disease (COVID-19) pandemic. Previously, we showed phenolic compounds corilagin and 1,3,6-tri-O-galloyl-β-D-glucose (TGG) inhibit interaction between SARS-CoV-2 spike protein receptor binding domain (RBD) angiotensin-converting enzyme (ACE2), target cell membrane host organism. Building these promising results, now assess effects two other crucial targets involved in replication, respectively: transmembrane protease serine (TMPRSS2) 3-chymotrypsin like (3CLpro) inhibitors. Since corilagin, TGG, tannic acid (TA) share many physicochemical structural properties, investigate TA targets. In this work, combination experimental methods (biochemical inhibition assays, surface plasmon resonance, quartz crystal microbalance with dissipation monitoring) confirms potential role prevention infectivity through extracellular RBD/ACE2 interactions TMPRSS2 3CLpro activity. Moreover, molecular docking prediction followed by dynamic simulation mechanics Poisson-Boltzmann area (MMPBSA) free energy calculation also shows binds RBD, TMPRSS2, higher affinities than TGG corilagin. Overall, results suggest naturally occurring candidate SARS-CoV-2.

Язык: Английский

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Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review

Antioxidants, Год журнала: 2022, Номер 11(8), С. 1609 - 1609

Опубликована: Авг. 19, 2022

The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease's progression not entirely understood, but there are strong indications that oxidative stress defense against reactive oxygen species crucial players. A big influx of immune cells to site infection marked by increase in nitrogen species. Our article aims highlight critical role emergence severity COVID-19 and, more importantly, shed light on underlying molecular genetic mechanisms. We have reviewed available literature clinical trials extract relevant variants within pathway associated with anti-oxidative therapies currently evaluated for treatment, particular glutathione N-acetylcysteine.

Язык: Английский

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On the Potential Role of the Antioxidant Couple Vitamin E/Selenium Taken by the Oral Route in Skin and Hair Health

Antioxidants, Год журнала: 2022, Номер 11(11), С. 2270 - 2270

Опубликована: Ноя. 17, 2022

The relationship between oxidative stress and skin aging/disorders is well established. Many topical oral antioxidants (vitamins C E, carotenoids, polyphenols) have been proposed to protect the against deleterious effect induced by increased reactive oxygen species production, particularly in context of sun exposure. In this review, we focused on combination vitamin E selenium taken supplements since both molecules act synergy either non-enzymatic enzymatic pathways eliminate lipids peroxides, which are strongly implicated hair disorders.

Язык: Английский

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Biomarkers Associated with Cardiovascular Disease in COVID-19

Cells, Год журнала: 2022, Номер 11(6), С. 922 - 922

Опубликована: Март 8, 2022

Coronavirus disease-19 (COVID-19) emerged late December 2019 in the city of Wuhan, China and has since spread rapidly all over world causing a global pandemic. While respiratory system is primary target disease manifestation, COVID-19 been shown to also affect several other organs, making it rather complex, multi-system disease. As such, cardiovascular involvement topic discussion beginning pandemic, primarily due early reports excessive myocardial injury these patients. Treating physicians are faced with multiple challenges management triage patients COVID-19, as severity highly variable ranging from an asymptomatic infection critical cases deteriorating intensive care treatment or even fatality. Laboratory biomarkers provide important prognostic information which can guide decision emergency department, especially atypical presentations. Several cardiac biomarkers, most notably high-sensitive troponin (hs-cTn) N-terminal pro-B-type natriuretic peptide (NT-proBNP), have valuable predictors prognosis COVID-19. The purpose this review was offer concise summary on discuss whether routine measurements warranted upon hospital admission.

Язык: Английский

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Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

Journal of Trace Elements in Medicine and Biology, Год журнала: 2022, Номер 75, С. 127099 - 127099

Опубликована: Ноя. 3, 2022

Язык: Английский

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