A Rising Star in Dark Teas: The Processing, Microorganisms, Chemicals, Bioactivities, and Safety of Qingzhuan Tea DOI

Yuxuan Pang,

Yang Wei, Kang Wei

и другие.

ACS Food Science & Technology, Год журнала: 2024, Номер 4(4), С. 796 - 812

Опубликована: Апрель 4, 2024

Qingzhuan tea (QZT), as a kind of representative dark tea, is daily necessity for people in the high-cold and high-fat diet areas northwest China, having many health effects such weight loss, lipid reduction, antioxidant ability. The production QZT has history more than 1000 years, which originated Yangloudong, Chibi City, Hubei Province. typically produced by subjecting sun-dried raw green to various processes, including pile fermentation, drying, autoclave formation, aging. Pile-fermentation, key step processing QZT, will form abundant microorganisms generate extracellular enzymes, leads series biochemical transformations intrinsic chemicals. unique sensory nutritional properties are formed through dynamic changes microorganisms. Meanwhile, there still potential risks food safety be resolved QZT. This paper reviews history, manufacturing, microorganisms, chemical composition, benefits, We first demonstrate panorama discuss opportunities challenges future. However, understanding not been integrated, comprehensive study requisite reveal association between consumption human further illuminate future QZT-derived products.

Язык: Английский

Blood-Based Biomarkers for Alzheimer’s Disease Diagnosis and Progression: An Overview DOI Creative Commons
Angelica Varesi, Adelaide Carrara,

Vitor Gomes Pires

и другие.

Cells, Год журнала: 2022, Номер 11(8), С. 1367 - 1367

Опубликована: Апрель 17, 2022

Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain. Although several studies have been conducted to unravel complex interconnected pathophysiology of AD, clinical trial failure rates high, no disease-modifying therapies are presently available. Fluid biomarker discovery for AD rapidly expanding field research aimed at anticipating diagnosis following progression over time. Currently, Aβ

Язык: Английский

Процитировано

81
Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies DOI Open Access

Francesca R. Buccellato,

Marianna D’Anca, Gianluca Martino Tartaglia

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 13900 - 13900

Опубликована: Сен. 9, 2023

In an ever-increasing aged world, Alzheimer’s disease (AD) represents the first cause of dementia and one chronic diseases in elderly people. With 55 million people affected, WHO considers AD to be a with public priority. Unfortunately, there are no final cures for this pathology. Treatment strategies aimed mitigate symptoms, i.e., acetylcholinesterase inhibitors (AChEI) N-Methyl-D-aspartate (NMDA) antagonist Memantine. At present, best approaches managing seem combine pharmacological non-pharmacological therapies stimulate cognitive reserve. Over last twenty years, number drugs have been discovered acting on well-established biological hallmarks AD, deposition β-amyloid aggregates accumulation hyperphosphorylated tau protein cells. Although previous efforts disappointed expectations, new era treating has working its way recently. The Food Drug Administration (FDA) gave conditional approval disease-modifying therapy (DMT) treatment aducanumab, monoclonal antibody (mAb) designed against Aβ plaques oligomers 2021, January 2023, FDA granted accelerated second antibody, Lecanemab. This review describes ongoing clinical trials DMTs therapies. We will also present future scenario based biomarkers that can detect preclinical or prodromal stages, identify at risk developing allow early curative treatment.

Язык: Английский

Процитировано

52
Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management DOI Creative Commons
Shehwaz Anwar, Faris Alrumaihi, Tarique Sarwar

и другие.

Biomolecules, Год журнала: 2024, Номер 14(6), С. 697 - 697

Опубликована: Июнь 14, 2024

The antioxidant defense mechanisms play a critical role in mitigating the deleterious effects of reactive oxygen species (ROS). Catalase stands out as paramount enzymatic antioxidant. It efficiently catalyzes decomposition hydrogen peroxide (H

Язык: Английский

Процитировано

52
Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease DOI Creative Commons
Andrila E. Collins, Tarek M. Saleh, Bettina E. Kalisch

и другие.

Antioxidants, Год журнала: 2022, Номер 11(2), С. 213 - 213

Опубликована: Янв. 23, 2022

It is estimated that the prevalence rate of Alzheimer’s disease (AD) will double by year 2040. Although currently available treatments help with symptom management, they do not prevent, delay progression of, or cure disease. Interestingly, a shared characteristic AD and other neurodegenerative diseases disorders oxidative stress. Despite profound evidence supporting role stress in pathogenesis AD, none treatment options address Recently, attention has been placed on use antioxidants to mitigate effects central nervous system. In preclinical studies utilizing cellular animal models, natural showed therapeutic promise when administered alone combination compounds. More recently, concept antioxidant therapy explored as novel approach preventing treating conditions present contributing factor. this review, relationship between pathology neuroprotective from sources are discussed. Additionally, potential preventatives and/or for examined, special paid combinations conjugates being investigated human clinical trials.

Язык: Английский

Процитировано

63
Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions DOI Creative Commons
Ana Tadijan, Ignacija Vlašić, Josipa Vlainić

и другие.

Antioxidants, Год журнала: 2022, Номер 11(10), С. 2049 - 2049

Опубликована: Окт. 18, 2022

In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic have received growing interest as treatment options in neurodegenerative conditions. various experimental settings, they displayed antioxidative, anti-inflammatory, antiapoptotic, immunomodulatory, neuroprotective effects. However, due to numerous targets downstream effectors of their action, cellular molecular mechanisms underlying these effects are rather complex still under discussion. Cannabinoids able neutralize free radicals modulate production reactive oxygen species activity antioxidative systems acting on CB1 CB2 cannabinoid receptors. The activation receptors stimulates signaling pathways involved defense survival (such phosphoinositide 3-kinase (PI3K)/Akt, mitogen-activated protein kinase (MAPK), Nrf2 pathways) regulates glutamatergic signaling, N-methyl-D-aspartate (NMDA) receptors, calcium influx, induction Ca2+-regulated cascades, whereas mediated by suppression microglial release prooxidative proinflammatory mediators. This review summarizes main new advances understanding cannabinoids. Because plethora possible pharmacological interventions related oxidative stress cannabinoid-mediated neuroprotection, future research should be directed towards a better interplay between activated signal transduction with aim improve efficacy targeting endocannabinoid system.

Язык: Английский

Процитировано

44
Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4) DOI
Nawab John Dar,

Urmilla John,

Nargis Bano

и другие.

Molecular Neurobiology, Год журнала: 2023, Номер 61(3), С. 1507 - 1526

Опубликована: Сен. 19, 2023

Язык: Английский

Процитировано

33
Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy DOI Creative Commons
Angelica Varesi, Lucrezia Irene Maria Campagnoli, Adelaide Carrara

и другие.

Antioxidants, Год журнала: 2023, Номер 12(1), С. 180 - 180

Опубликована: Янв. 12, 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although substantial research has been conducted to elucidate the complex pathophysiology of AD, therapeutic approach still limited efficacy in clinical practice. Oxidative stress (OS) established as an early driver several age-related diseases, including neurodegeneration. In increased levels reactive oxygen species mediate neuronal lipid, protein, nucleic acid peroxidation, mitochondrial dysfunction, synaptic damage, inflammation. Thus, identification novel antioxidant molecules capable detecting, preventing, counteracting AD onset progression utmost importance. However, although studies have published, comprehensive up-to-date overviews principal anti-AD agents harboring properties remain scarce. this narrative review, we summarize role vitamins, minerals, flavonoids, non-flavonoids, mitochondria-targeting molecules, organosulfur compounds, carotenoids non-enzymatic antioxidants with diagnostic, preventative, potential, thereby offering insights into relationship between OS

Язык: Английский

Процитировано

25
Oxidative stress–mediated neuroinflammation in Alzheimer’s disease DOI

Sayed Mohammed Firdous,

Sahabaj Ali Khan, Amritangshu Maity

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 4, 2024

Язык: Английский

Процитировано

16
Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects DOI
Md. Faysal,

Zerrouki Dehbia,

Mehrukh Zehravi

и другие.

Neurochemical Research, Год журнала: 2024, Номер 49(8), С. 1926 - 1944

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

11
Porous Materials for Early Diagnosis of Neurodegenerative Diseases DOI Creative Commons
Payam Arghavani, Hossein Daneshgar, Soheil Sojdeh

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Abstract Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies the absence of curative treatments. Despite advances symptomatic management, early diagnosis remains essential for mitigating progression improving patient outcomes. Traditional diagnostic methods, such as MRI, PET, cerebrospinal fluid biomarker analysis, are often inadequate detection these diseases. Emerging porous materials, including metal–organic frameworks (MOFs), covalent–organic (COFs), MXene, zeolites, silicon, offer promising new approaches neurodegenerative These characterized by highly tunable physicochemical properties, have potential capture concentrate disease‐specific biomarkers amyloid‐beta (Aβ), tau protein, alpha‐synuclein (α‐Syn). The integration materials into advanced biosensors real‐time holds promise revolutionizing neurodiagnostic, enabling non‐invasive, sensitive, specific platforms. Furthermore, incorporation artificial intelligence (AI) machine learning (ML) techniques analysis sensor data enhances accuracy allows more efficient interpretation profiles. AI ML can optimize feature selection, improve pattern recognition, facilitate prediction progression, making them indispensable tools personalized medicine. This review explores diagnostics, emphasizing design, functionality, synergistic role advancing clinical applications.

Язык: Английский

Процитировано

2