Plant Physiology and Biochemistry, Год журнала: 2023, Номер 202, С. 107934 - 107934
Опубликована: Авг. 3, 2023
Язык: Английский
Nutrients, Год журнала: 2023, Номер 15(8), С. 1947 - 1947
Опубликована: Апрель 18, 2023
In recent years, people have tended to consume phytonutrients and nutrients in their daily diets. Isorhamnetin glycosides (IGs) are an essential class of flavonoids derived from dietary medicinal plants such as Opuntia ficus-indica, Hippophae rhamnoides, Ginkgo biloba. This review summarizes the structures, sources, quantitative qualitative analysis technologies, health benefits, bioaccessibility, marketed products IGs. Routine innovative assay methods, IR, TLC, NMR, UV, MS, HPLC, UPLC, HSCCC, been widely used for characterization quantification All therapeutic effects IGs discovered date collected discussed this study, with emphasis on relevant mechanisms health-promoting effects. exhibit diverse biological activities against cancer, diabetes, hepatic diseases, obesity, thrombosis. They exert through multiple networks underlying molecular signaling pathways. Owing these could be utilized make foods functional foods. higher bioaccessibility plasma concentrations longer average residence time blood than aglycones. Overall, very promising excellent application potential.
Язык: Английский
Процитировано
27
Antioxidants, Год журнала: 2023, Номер 12(1), С. 155 - 155
Опубликована: Янв. 9, 2023
The contention that flavonoids' oxidation would necessarily lead to a loss of their antioxidant properties was recently challenged by the demonstration quercetin leads formation 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (Que-BZF), metabolite whose potency notably higher than its precursor. Here, we compared and expanded former observation analogue kaempferol. Oxidation kaempferol led mixture metabolites included 2-(4-hydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (Kae-BZF). Following chromatographic isolation Kae-BZF from such mixture, antioxidant, mitochondria- cell-protecting, NF-kB-inhibiting effects were assessed, with those Que-BZF, in Caco-2 cells exposed indomethacin as source ROS. concentrations Que-BZF (100 nm) (1 needed attain maximal protection 50- 5000-fold lower respective precursors. differences also seen when abilities inhibit indomethacin-induced activation NF-kB compared. These data not only reveal oxidative conversion into 2-benzoyl-2-hydroxy-3(2H)-benzofuranones (BZF) results considerable amplification original properties, but case kaempferol, is 100-fold greater quercetin.
Язык: Английский
Процитировано
23
Biochemical Pharmacology, Год журнала: 2024, Номер 228, С. 116165 - 116165
Опубликована: Март 26, 2024
In this comprehensive review we tried to reassess the role of phytochemicals in cancer chemoprevention. The exploration "synergistic effect" concept, advocating combined chemopreventive agents, faces challenges like low bioavailability. incorporates personal, occasionally controversial, viewpoints on natural compounds' preventive capabilities, delving into mechanisms. Prioritizing significant contributions within vast research domain, aim stimulating discussion provide a insight evolving prevention. While early years downplayed phytochemicals, late nineties witnessed shift, with leaders exploring their potential alongside synthetic compounds. Challenges faced by chemoprevention, such as limited pharmaceutical interest and cost-effectiveness issues, persist despite successful drugs. Recent studies, including EPIC study, nuanced insights, indicating modest risk reduction for increased fruit vegetable intake. Phytochemicals, once attributed antioxidant effects, face scrutiny due bioavailability conflicting evidence. Nrf2-EpRE signaling pathway microbiota-mediated metabolism emerge mechanisms, highlighting complexity understanding phytochemical mechanisms
Язык: Английский
Процитировано
14
The Plant Journal, Год журнала: 2024, Номер 118(5), С. 1550 - 1568
Опубликована: Фев. 27, 2024
The increased soil salinity is becoming a major challenge to produce more crops and feed the growing population of world. In this study, we demonstrated that overexpression OsDIR55 gene enhances rice salt tolerance by altering root diffusion barrier. broadly expressed in all examined tissues organs with maximum expression levels at lignified regions roots. Salt stress upregulates an abscisic acid (ABA)-dependent manner. Loss-function compromised improved development CS barrier, manifested decreased width CS, respectively, ultimately affected permeability apoplastic barrier deficiency resulted Na
Язык: Английский
Процитировано
8
Heliyon, Год журнала: 2024, Номер 10(7), С. e28456 - e28456
Опубликована: Март 22, 2024
High volume of postharvest materials including peels from citrus fruits is periodically generated, which contributes to environmental pollution. Investigating the chemical composition cum antioxidant property these 'wastes' would be instructive in achieving value addition food and pharmaceutical chain. On this premise, study carried out phytochemical screening activity three (3) commonly cultivated varieties namely Citrus sinensis 'valencia', 'washinton' 'thompson navel'. The were extracted using ethanol hexane a Soxhlet extractor thereafter subjected Gas Chromatography/Mass Spectrometry (GC/MS) analyses, ferric ion reducing power (FRAP), hydrogen peroxide scavenging cupric capacity (CUPRAC) assays evaluate their potentials. Results show that peel extracts contain alkaloids, flavonoids, phenols, phytosterols, diterpenes, tannins glycosides. GC/MS analysis identified about 48 compounds each extract; with predominant bioactive being limonene (16.5%), ascorbic acid (17.7%), stearic (26.3%), linalool (4.7%), linoleic (16.18%), palmitic (15.23%), pentadecyclic (1.1%). Ethanol Valencia exhibited higher FRAP (9.09 ± 0.13) CUPRAC (2.04 0.06) values while extract Ibadan sweet demonstrated greater (1.39 0.00). are rich excellent may serve as potential sources natural antioxidants for products or formulations.
Язык: Английский
Процитировано
8
Brain Sciences, Год журнала: 2023, Номер 13(9), С. 1258 - 1258
Опубликована: Авг. 29, 2023
Flavonoids are a large subgroup of polyphenols known to be sourced from over 6000 natural products, including fruits, vegetables, bark, and herbs. Due their antioxidant properties, flavonoids have been implicated as therapy source for many diseases conditions, inflammation, vasculitis, venous insufficiency, hemorrhoids. Currently, some being researched ability concerning neuroprotection. These can penetrate the blood–brain barrier and, depending on specific flavonoid, retain adequate bioavailability in certain brain regions. Further data suggest that could strong anti-inflammatory effect brain, which not only robust therapeutic neuroinflammatory such Alzheimer’s Disease or Parkinson’s but also ischemic hemorrhagic conditions stroke. While flavonoid toxicity exists, they relatively safe non-invasive drugs origins. As such, exploring mechanisms therapies may highlight establish viable stroke patients. stated, already isolated, purified, implemented both vitro vivo experiments. these proceed clinical trials, it will important understand how function therapy, primarily antioxidants, by other secondary mechanisms. This review aims elucidate those explore neuroprotective role flavonoids.
Язык: Английский
Процитировано
20
Plants, Год журнала: 2023, Номер 12(3), С. 517 - 517
Опубликована: Янв. 23, 2023
Land plants survive the challenges of new environments by evolving mechanisms that protect them from excess irradiation, nutrient deficiency, and temperature water availability fluctuations. One such evolved mechanism is regulation shoot/root growth ratio in response to balancing actions hormones auxin cytokinin. Plant terrestrialization co-occurred with a dramatic expansion secondary metabolism, particularly evolution establishment flavonoid biosynthetic pathway. Flavonoid biosynthesis responsive wide range stresses, numerous synthesized species offer two main evolutionary advantages land plants. First, flavonoids are antioxidants thus defend against those adverse conditions lead overproduction reactive oxygen species. Second, aid protecting deficiency modulating root development establishing symbiotic relations beneficial soil fungi bacteria. Here, we review different aspects relationships between auxin/cytokinin module flavonoids. The current body knowledge suggests whereas both cytokinin regulate biosynthesis, act fine-tune only auxin, which turn regulates action. This conclusion agrees established master regulatory function controlling ratio.
Язык: Английский
Процитировано
19
Antioxidants, Год журнала: 2024, Номер 13(3), С. 325 - 325
Опубликована: Март 6, 2024
The historical use of plants as sources natural compounds has persisted over time. Increasing the intake bioactive substances shows significant potential for promoting overall well-being and health. This study delves into pigments, phenolic composition, profile, along with antioxidant properties, leaf extracts rich in bioactives from Azores region, contributing to sustainable primary food production. Analyses encompassed chlorophylls, carotenoids, total phenols, ortho-diphenols, flavonoids, well capacity assessment, polyphenolic profiling, quantification. Psidium guajava L. Smallanthus sonchifolius (Poepp.) H.Rob. exhibited elevated chlorophyll content, while Colocasia esculenta (L.) Schott displayed highest carotenoid levels. Annona cherimola Mill., Eriobotrya japonica (Thunb.) Lindl, demonstrated pronounced flavonoids. These findings align heightened capacity. HPLC–DAD (high-performance liquid chromatography diode-array detection) characterization unveiled hydroxycinnamic acids E. Ipomea batatas Lam. compared A. C. increased flavone content. Among quantified compounds, flavonols were ones that predominantly contribution these leaves. research highlights Azorean plants’ potential, fostering product development better
Язык: Английский
Процитировано
6
Food Chemistry, Год журнала: 2024, Номер 467, С. 142266 - 142266
Опубликована: Ноя. 27, 2024
Язык: Английский
Процитировано
6
Antioxidants, Год журнала: 2022, Номер 11(10), С. 1849 - 1849
Опубликована: Сен. 20, 2022
The main objective of this work is to evaluate the potential utility an Achillea millefolium extract (yarrow extract, YE) in control H. pylori infection. supercritical anti-solvent fractionation (SAF) process YE allowed obtaining two different fractions: yarrow’s precipitated fraction (YPF), enriched most polar phenolic compounds (luteolin-7-O-glucoside, luteolin, and 3,5-dicaffeoylquinic acid), separator (YSF), monoterpenes sesquiterpenes, mainly containing camphor, artemisia ketone, borneol. was effective reducing reactive oxygen species (ROS) production human gastric AGS cells by 16% 29%, depending on strain. YPF had highest inhibitory activity (38–40%) for ROS production. modulated inflammatory response cells, decreasing IL-8 53% 64%. This inhibition also showed a strain-dependent character. YSF exhibited similar behavior, production, suggesting that both essential oils could contribute inhibition. antibacterial against (6.3–7.1 log CFU reduction, strain) lower MIC (0.08 mg/mL). Results obtained have shown SAF fractions (YPF YSF) were as antioxidant, anti-inflammatory, agents regardless strain characteristics.
Язык: Английский
Процитировано
25