Cannabinoids in the Modulation of Oxidative Signaling

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2513 - 2513

Опубликована: Янв. 28, 2023

Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), components of the endocannabinoids system, N-arachidonoylethanolamide (anandamide, AEA) 2-arachidonoylglycerol (2-AG), are extensively studied to investigate their numerous biological effects, including powerful antioxidant effects. Indeed, a series recent studies have indicated that many disorders characterized by alterations in intracellular which lead macromolecule damage. These pathological conditions an unbalanced, most often increased, reactive oxygen species (ROS) production. For this study, it was interest recapitulate properties these natural for part CBD THC, on production ROS modulation redox state, with emphasis use various reduction can be clinically useful, neurodegenerative disorders, inflammatory conditions, autoimmunity, cancers. The further development ROS-based fundamental research focused cannabis compounds could beneficial future clinical applications.

Язык: Английский

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Hydrogels: a promising therapeutic platform for inflammatory skin diseases treatment

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(33), С. 8007 - 8032

Опубликована: Янв. 1, 2024

Inflammatory skin diseases, such as psoriasis and atopic dermatitis, pose significant health challenges due to their long-lasting nature, potential for serious complications, risks, which requires treatments that are both effective exhibit minimal side effects. Hydrogels offer an innovative solution biocompatibility, tunability, controlled drug delivery capabilities, enhanced treatment adherence minimized effects risk. This review explores the mechanisms guide design of hydrogel therapeutic platforms from multiple perspectives, focusing on components hydrogels, adjustable physical chemical properties, interactions with cells drugs underscore clinical potential. We also examine various agents dermatitis can be integrated into including traditional drugs, novel compounds targeting oxidative stress, small molecule biologics, emerging therapies, offering insights advantages. Additionally, we trial data evaluate effectiveness safety hydrogel-based in managing under complex disease conditions. Lastly, discuss current future opportunities therapeutics treating improving barrier penetration developing multifunctional highlight enhance long-term stability.

Язык: Английский

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A bibliometrics study on the status quo and hot topics of pathogenesis of psoriasis based on Web of Science

Skin Research and Technology, Год журнала: 2024, Номер 30(1)

Опубликована: Янв. 1, 2024

Abstract Background Psoriasis is an immune‐mediated chronic inflammatory skin disease. Great progress has been made in the pathogenesis of psoriasis recent years, but there no bibliometric study on psoriasis. The purpose this was to use bibliometrics method analyze research overview and hot spots 10 so as further understand development trend frontier field. Methods core literatures were searched Web Science database, analyzed by VOSviewer, CiteSpace, Bibliometrix terms annual publication volume, country, institution, author, journal, keywords, on. Results A total 3570 included. China United States main countries field, Rockefeller University institution. Krueger JG, had highest number publications greatest influence, Boehncke (2015) most cited local literature. J INVEST DERMATOL takes top spot Dermatol articles citation frequency. hotspots are follows: (1) interaction between innate adaptive immunity related loop dominated Th17 cells IL‐23/IL‐17 axis still key mechanisms psoriasis; (2) molecular genetic studies represented Long Non‐Coding RNA (LncRNA); (3) integrated multi‐omics techniques gut microbiota; (4) Exploring comorbidity mechanism Metabolic Syndrome (MetS). Conclusion This a summary current status psoriasis, which will provide some reference for scholars studying

Язык: Английский

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Alleviative effects of combined topical melatonin and rutin on imiquimod-induced psoriasis mouse model

Pharmacia, Год журнала: 2024, Номер 71, С. 1 - 13

Опубликована: Сен. 3, 2024

Background : Psoriasis is a longstanding autoimmune dermatosis with thickened, reddish-brown, and flaking skin lesions. Melatonin an indolamine hormone exhibiting antioxidant, anti-inflammatory, anti-proliferative actions. Rutin nutritional flavonoid possessing antioxidative, immunomodulatory properties. Aim To explore the potential anti-psoriatic activity of combined topical melatonin rutin. Methods 70 albino mice were divided into 7 groups 10 each. The impacts clinical observation, histopathological examination, biomarker analysis estimated. Results Combined rutin effectively diminished imiquimod-induced elevated PASI Baker’s scores corrected aberrations. Diminished inflammatory indicators like TNF-α IL-17A, angiogenic elements VEGF, oxidative MDA, proliferative Ki-67 also noted. Conclusion have profound effects.

Язык: Английский

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Etiopathogenesis of Psoriasis: Integration of Proposed Theories

Immunological Investigations, Год журнала: 2024, Номер 53(3), С. 348 - 415

Опубликована: Янв. 19, 2024

Psoriasis is a chronic inflammatory disease characterized by squamous and erythematous plaques on the skin involvement of immune system. Global prevalence for psoriasis has been reported around 1–3% with higher incidence in adults similar proportions between men women. The risk factors associated are both extrinsic intrinsic, out which polygenic predisposition highlight latter. etiology not yet fully described, but several hypothesis have proposed: 1) autoimmunity based over-expression antimicrobial peptides such as LL-37, proteins ADAMTSL5, K17, hsp27, or lipids synthesized PLA2G4D enzyme, all may serve autoantigens to promote differentiation autoreactive lymphocytes T unleash response; 2) dysbiosis microbiota gained relevance due observations loss diversity participation pathogenic bacteria Streptococcus spp. Staphylococcus fungi Malassezia Candida virus HPV, HCV, HIV psoriatic plaques; 3) oxidative stress hypothesis, most recent one, describes that cell injury release proinflammatory mediators leads activate Th1/Th17 axis observed caused reactive oxygen species imbalance oxidant antioxidant mechanisms. This review aims describe mechanisms involved three hypotheses etiopathogeneses psoriasis.

Язык: Английский

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Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species

Redox Biology, Год журнала: 2024, Номер 70, С. 103055 - 103055

Опубликована: Янв. 23, 2024

Nanozymes with superior antioxidant properties offer new hope for treating oxidative stress-related inflammatory skin diseases. However, lacking sufficient catalytic activity or having complex material designs limit the application of current metallic nanozymes in Here, we report a simple and effective twin-defect platinum nanowires (Pt NWs) enzyme multiple mimetic enzymes broad-spectrum ROS scavenging capability treatment diseases mice (including psoriasis rosacea). Pt NWs simultaneous superoxide dismutase, glutathione peroxidase catalase exhibit cytoprotective effects against ROS-mediated damage at extremely low doses significantly improve outcomes psoriasis- rosacea-like mice. Meanwhile, these ultrasmall sizes allow nanomaterials to effectively penetrate do not produce significant biotoxicity. Therefore, have potential applications related stress inflammation.

Язык: Английский

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Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives

Biomolecules, Год журнала: 2022, Номер 12(12), С. 1904 - 1904

Опубликована: Дек. 19, 2022

Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays pivotal role pathogenesis and persistence lesions. Phototherapy represents one most used therapeutic options, with benefits clinical picture. Studies have demonstrated immunomodulatory effect phototherapy its reducing molecule hallmarks oxidative stress. In this review, we report data present literature dealing main signaling molecular pathways involved stress after to target atopic dermatitis-affected cells. Since flare-up, new research lines could be opened study drugs that act on mechanism, perhaps concert phototherapy.

Язык: Английский

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Resveratrol and Its Derivatives in Inflammatory Skin Disorders—Atopic Dermatitis and Psoriasis: A Review

Antioxidants, Год журнала: 2023, Номер 12(11), С. 1954 - 1954

Опубликована: Ноя. 2, 2023

Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases whose prevalence has increased worldwide in recent decades. These disorders contribute to patients’ decreased quality of life (QoL) constitute a socioeconomic burden. New therapeutic options for AD based on natural compounds being investigated. include resveratrol (3,5,40-trihydroxystilbene) its derivatives, which produced by many plant species, including grapevines. Resveratrol gained interest since the term “French Paradox”, refers improved cardiovascular outcomes despite high-fat diet French population, was introduced. derivatives have demonstrated various health benefits. In addition anti-cancer, anti-aging, antibacterial effects, there also anti-inflammatory antioxidant effects that can affect molecular pathways disorders. A comprehensive understanding these mechanisms may help develop new therapies. Numerous vivo vitro studies been conducted properties compounds. However, regarding treating psoriasis, still unexplained need clinical trials. Considering this, this review, we discuss summarize most critical research animal cell models mimicking psoriasis.

Язык: Английский

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Reactive oxygen species-responsive supramolecular deucravacitinib self-assembly polymer micelles alleviate psoriatic skin inflammation by reducing mitochondrial oxidative stress

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 10, 2024

Introduction The new topical formula is urgent needed to meet clinical needs for majority mild patients with psoriasis. Deucravacitinib exerts outstanding anti-psoriatic capacity as an oral TYK2 inhibitor; however, single therapy insufficient target the complicated psoriatic skin, including excessive reactive oxygen species (ROS) and persistent inflammation. To address this need, engineered smart nano-therapeutics hold potential delivery of deucravacitinib. Methods hydrophobic was loaded into polyethylene glycol block-polypropylene sulphide (PEG-b-PPS) transdermal in treatment oxidative stress model HaCaT psoriasis established by TNF-α IL-17A vitro . JC-1 assay, DCFH-DA staining mtDNA copy number were utilized assess mitochondrial function. 0.75% Carbopol ® 934 incorporated SPMs produce hydrogels Rhb labeled monitor penetration Immunofluorescence. In vivo , we IMQ-induced evaluate therapeutic effect Car@Deu@PEPS. Results Deu@PEPS exerted effects restoring DNA membrane HaCaT. Car@Deu@PEPS supramolecular micelle had longer retention time dermis ROS microenvironment. Topical application significantly restored normal epidermal architecture skin abrogation splenomegaly dermatitis model. inhibited STAT3 signaling cascade a corresponding decrease levels differentiation proliferative markers Keratin 17 Cyclin D1, respectively. Meanwhile, alleviated generation subsequent NLRP3 inflammasome-mediated pyroptosis. Conclusion prominent anti-inflammatory anti-oxidative effects, which may offers more patient-acceptable fewer adverse compared

Язык: Английский

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Kaempferol modulates IFN-γ induced JAK-STAT signaling pathway and ameliorates imiquimod-induced psoriasis-like skin lesions

International Immunopharmacology, Год журнала: 2022, Номер 114, С. 109585 - 109585

Опубликована: Дек. 15, 2022

Язык: Английский

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