Inflammaging and Immunosenescence as Part of Skin Aging—A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7784 - 7784

Опубликована: Апрель 24, 2023

Inflammaging and immunosenescence are associated with aging of the human body, but there key differences between them. Immunosenescence aims to adapt body systems aging, while inflammaging is considered a consequence immunosenescence. There has been much research in area recently, yet our understanding ability develop interventions decrease harmful effect on insufficient. This review focused processes skin. We aimed identify factors that influence inflammaging, skin their mechanisms. discussed role triggering (e.g., UV radiations, changes bioavailability nitric oxide, senescence-associated secretory phenotype factors, reactive oxygen species) inhibiting can potentially be used as anti-aging treatments, well idea geroprotectors senotherapeutics. concluded knowledge external help people improve health conditions, biochemical researchers understand process minimize impact body. Further needed better slow down or accelerate inflammaging.

Язык: Английский

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Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Янв. 23, 2024

Abstract Background CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during aging. Furthermore, persistently high level of promotes longevity and ameliorates an age-related skin phenotype transgenic mice. Here we translate the genetic evidence into pharmaceutical application using potent activator, hesperetin, which enhances expression HEK001 human keratinocytes from older person. We also treated naturally aged mice order to study activator’s anti-aging efficacy. Methods studied biological effects hesperetin on aging using, firstly, cell-based platform, namely keratinocyte cell line established Secondly, used mouse model, old at 21-month old. In latter case, investigate efficacy ultraviolet B (UVB)-induced photoaging skin. identify underlying mechanisms potential pathways involved this process carried out transcriptomic analysis. Finally, knockdown Cisd2 knockout were Cisd2-dependent Results Four findings are pinpointed. Firstly , skin, mainly expressed proliferating epidermal basal layer and, furthermore, sun-exposed epidermis. Secondly person, mitochondrial function protects against reactive oxygen species-induced oxidative stress via increased expression; enhancement CISD2-dependent. Additionally, alleviates UVB-induced damage suppresses matrix metalloproteinase-1 expression, being major indicator keratinocytes. Thirdly analysis revealed that modulates panel differentially genes associated with function, redox homeostasis, inflammation attenuate senescence. Intriguingly, activates two known longevity-associated regulators, FOXO3a FOXM1, suppress senescence-associated secretory phenotype. Finally ameliorate occurs mechanism involving CISD2. Most strikingly, late-life treatment started lasting for 5 months, able retard rejuvenate Conclusions Our results reveal pharmacological elevation stage feasible approach effectively mitigating both intrinsic extrinsic could act as functional food or skincare product fighting

Язык: Английский

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Anti-Aging Effects of Flavonoids from Plant Extracts

Foods, Год журнала: 2024, Номер 13(15), С. 2441 - 2441

Опубликована: Авг. 2, 2024

Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues' cells' morphology functionality consequently being responsible for aging-related diseases. Taking into account actual preoccupations of both consumers researchers, healthy anti-aging alternatives are intensively studied in order to address such concerns. Due their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights possibilities use extracted from various plants potential on skin, brain, heart. Moreover, anticarcinogenic, anti-inflammatory, anti-diabetic properties summarized, along with senescence-associated mechanisms. Both nutraceutical cosmeceutical fields continuously developing originating promising candidates obtain products. Thus, bioactive compounds' extraction subsequent involvement innovative product manufacturing must carefully performed while aware intrinsic extrinsic factors that may affect phytochemicals' structures, bioavailability, health effects.

Язык: Английский

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Low-temperature cold plasma promotes wound healing by inhibiting skin inflammation and improving skin microbiome

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Фев. 20, 2025

Wound healing includes four consecutive and overlapping stages of hemostasis, inflammation, proliferation, remodeling. Factors such as aging, infection, chronic diseases can lead to wounds delayed healing. Low-temperature cold plasma (LTCP) is an emerging physical therapy for wound healing, characterized by its safety, environmental friendliness, ease operation. This study utilized a self-developed LTCP device investigate biological effects mechanisms on in adult elderly mice. Histopathological studies found that significantly accelerated the rate skin mice, with particularly pronounced markedly inhibit expression pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) senescence-associated secretory phenotype factors (MMP-3, MMP-9), while increasing tissue repair-related factors, VEGF, bFGF, TGF-β, COL-I, α-SMA. It also regulated genes related cell proliferation migration (Aqp5, Spint1), inflammation response (Nlrp3, Icam1), angiogenesis (Ptx3, Thbs1), promoting apoptosis. Furthermore, treatment reduced relative abundance harmful bacteria Delftia, Stenotrophomonas, Enterococcus, Enterobacter wounds, beneficial Muribaculaceae, Acinetobacter, Lachnospiraceae NK4A136_group, un_f__Lachnospiraceae, thereby improving microbial community structure wounds. These research findings are significant implications understanding mechanism well clinical applications especially aging skin.

Язык: Английский

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Revitalizing Photoaging Skin through Eugenol in UVB-Exposed Hairless Mice: Mechanistic Insights from Integrated Multi-Omics

Antioxidants, Год журнала: 2024, Номер 13(2), С. 168 - 168

Опубликована: Янв. 29, 2024

Chronic ultraviolet (UV) exposure causes photoaging, which is primarily responsible for skin damage. Nutritional intervention a viable strategy preventing and treating photoaging. Eugenol (EU) presents anti-inflammatory antioxidant properties, promotes wound healing, provides contact dermatitis relief. This study explored the ability of EU to mitigate photoaging caused by UVB in vitro vivo. alleviated UVB-induced photodamage cells, including oxidative stress damage extracellular matrix (ECM) decline. Dietary promoting barrier repair, facilitating tissue regeneration, modulating microenvironment photoaged mice. The transcriptome sequencing results revealed that changed gene expression profiles. Subsequent pathway enrichment analyses indicated might reverse pivotal ECM–receptor interaction cytokine–cytokine receptor signaling pathways. Furthermore, intestinal dysbiosis induced chronic exposure. Spearman analysis further close connection between gut microbiota Considering near-inevitable modern living, findings showed effectively reverted offering potential addressing extrinsic aging.

Язык: Английский

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Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 15, 2024

Intrinsic and extrinsic factors, including lifestyle sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead aging. Senescent cells have a specific secretome, called the senescence-associated secretory phenotype (SASP) includes MMPs, CXCLs S100A8/9. Reducing SASP with senotherapeutics is promising strategy reduce Here we evaluated effect of formula containing niacinamide hyaluronic acid, are known limit senescence We conducted three different studies. (1) Ex vivo explants treated had more collagen glycosaminoglycan. (2) In clinical trial forty-four women, two months treatment improved fine lines, wrinkles, luminosity, smoothness, homogeneity, plumpness. (3) third study on thirty one arm for took biopsies gene expression. 101 mRNAs 13 miRNAs were differentially expressed. observed likely senomorphic effect, as there was decrease many genes MMP12 CXCL9 significant downregulation autocrine signaling genes: S100A8 S100A9. These pharmaco-clinical results first demonstrate properties an effective anti-aging skin.

Язык: Английский

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The Role of p53 in Regulating Chronic Inflammation and PANoptosis in Diabetic Wounds

Aging and Disease, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Diabetic wounds represent a formidable challenge in the clinical management of diabetes mellitus, markedly diminishing patient's quality life. These arise from multifaceted etiology, with pathophysiological underpinnings remaining elusive and complex. Diabetes precipitates neuropathies vasculopathies lower extremities, culminating infections, ulcerations, extensive tissue damage. The hallmarks non-healing diabetic include senescence, persistent inflammation, heightened apoptosis, attenuated cellular proliferation. TP53 gene, pivotal tumor suppressor frequently silenced human malignancies, orchestrates proliferation, DNA repair, apoptosis. While p53 is integral cell cycle regulation, its role initial repair appears to be deleterious. In typical cutaneous wounds, levels transiently dip, swiftly reverting baseline. Yet protracted activation impedes healing via two distinct pathways: i) activating p53-p21-Retinoblastoma (RB) axis, which halts cycle, ii) upregulating cGAS-STING nuclear factor-kappaB (NF-κB) cascades, instigating ferroptosis pyroptosis. Furthermore, intersects various metabolic pathways, including glycolysis, gluconeogenesis, oxidative phosphorylation, autophagy. may drive reprogramming, thus potentially derailing macrophage polarization. This review synthesizes case studies investigating therapeutic modulation care. summation, modulates chronic inflammation aging within implicated novel death modality, encompassing pyroptosis, hinders reparative process.

Язык: Английский

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Critical Signalling Pathways Activating Cellular Senescence and Immortalization

Опубликована: Янв. 1, 2025

Язык: Английский

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Cutaneous Redox Senescence

Biomedicines, Год журнала: 2024, Номер 12(2), С. 348 - 348

Опубликована: Фев. 1, 2024

Our current understanding of skin cell senescence involves the role environmental stressors (UV, O3, cigarette smoke, particulate matter, etc.), lifestyle (diet, exercise, etc.) as well genetic factors (metabolic changes, hormonal, etc.). The common mechanism action these is disturbance cellular redox balance characterized by increased free radicals and reactive oxygen species (ROS), when overload intrinsic antioxidant defense system, it can lead to an oxidative stress condition. main mechanisms that activate in involve (1) damage telomeres causing their shortening; (2) oxidation proteomes DNA damage; (3) a lysosomal mass through activity resident enzymes such senescence-associated β-galactosidase (SA-β-gal) other proteins are products activity; (4) expression SASP, particular pro-inflammatory cytokines transcriptionally regulated NF-κB. However, targets ROS on proteome (oxi-proteome), followed telomeres, nucleic acids (DNAs), lipids, proteins, cytoplasmic organelles. As result, cycle arrest pathways, lipid peroxidation, content dysfunctional mitochondria, SASP synthesis occur. Furthermore, cells increases p16INK4A p53 inhibitors Rb CDks, which important for maintaining cycle. also promotes inactivation mTOR-mediated autophagic apoptotic leading senescence. markers alone cannot establish state senescence, multiple analyses encouraged confirmation. An updated more comprehensive approach investigating should include further assays ox-inflammatory molecular pathways consolidate cutaneous

Язык: Английский

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Dietary supplementation with α-ionone alleviates chronic UVB exposure-induced skin photoaging in mice

Food & Function, Год журнала: 2024, Номер 15(4), С. 1884 - 1898

Опубликована: Янв. 1, 2024

Dietary α-ionone mitigates chronic UVB-induced skin photoaging by reducing wrinkles, alleviating dryness, promoting extracellular matrix, and inhibiting cellular senescence in mice.

Язык: Английский

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