Опубликована: Янв. 1, 2024
8-oxo-2-deoxiguanosina 8-oxo-dG: 8-oxo-2'-deoxiguanosina ADH: álcool desidrogenase AKT:
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июль 3, 2024
Diabetic cardiomyopathy (DCM) is a myocardial-specific microvascular disease caused by diabetes that affects the structure and function of heart considered to be leading cause morbidity death in patients with diabetes. Currently, there no specific treatment or preventive drug for DCM, an urgent need develop new drugs treat DCM. Traditional Chinese medicine (TCM) has rich experience its characteristics multi-target, multi-pathway, multi-component, few side effects can effectively deal complexity long-term nature Growing evidence suggests myocardial fibrosis, inflammation, oxidative stress, apoptosis, cardiac hypertrophy, advanced glycation end product deposition were main pathologic mechanisms According pathological mechanism this study revealed potential metabolites prescriptions TCM against DCM from perspective signaling pathways. The results showed TGF-β/Smad, NF-κB, PI3K/AKT, Nrf2, AMPK, NLRP3, Wnt/β-catenin pathways key aim was summarize update screen targets candidates provide ideas more experimental clinical use
Язык: Английский
Процитировано
19
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116909 - 116909
Опубликована: Июнь 8, 2024
Lung cancer is a prevalent malignant tumor and leading cause of cancer-related fatalities globally. However, current treatments all have limitations. Therefore, there an urgent need to identify readily available therapeutic agent counteract lung development progression. Luteolin flavonoid derived from vegetables herbs that possesses preventive effects on various cancers. With the goal providing new directions for treatment cancer, we review here recent findings luteolin so as provide ideas anti-lung drugs. The search focused studies published between January 1995 2024 explored use in cancer. A comprehensive literature was conducted SCOPUS, Google Scholar, PubMed, Web Science databases using keywords "luteolin" "lung cancer." By collecting previous literature, found has multiple mechanisms effects, including promotion apoptosis cells; inhibition cell proliferation, invasion metastasis; modulation immune responses. In addition, it can be used adjuvant radio-chemotherapy helps ameliorate complications. This summarizes structure, natural sources, physicochemical properties pharmacokinetics luteolin, focuses mechanism
Язык: Английский
Процитировано
9
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Июнь 10, 2024
This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on integumentary, respiratory, cardiovascular, urinary, and skeletal systems, study highlights versatility MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge central mediators antioxidative anti-inflammatory effects. From expediting diabetic wound healing to mitigating oxidative stress-induced skin injuries, alleviating acute lung even offering solutions for conditions like myocardial infarction renal ischemia-reperfusion injury, demonstrate promising efficacy. Their adaptability different administration routes identifying specific factors opens avenues innovative regenerative strategies. positions candidates future clinical applications, providing a overview medicine.
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7530 - 7530
Опубликована: Июль 9, 2024
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.
Язык: Английский
Процитировано
8
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
6
Antioxidants, Год журнала: 2024, Номер 13(8), С. 1012 - 1012
Опубликована: Авг. 20, 2024
Oxidative stress (OS) is a key factor in the generation of various pathophysiological conditions. Nuclear erythroid 2 (NF-E2)-related (Nrf2) major transcriptional regulator antioxidant reactions. Heme oxygenase-1 (HO-1), gene regulated by Nrf2, one most critical cytoprotective molecules. In recent years, Nrf2/HO-1 has received widespread attention as regulatory pathway for intracellular defense against oxidative stress. It considered potential target treatment inflammatory bowel disease (IBD). This review highlights mechanism action and therapeutic significance IBD complications (intestinal fibrosis colorectal cancer (CRC)), well phytochemicals targeting IBD. The results suggest that effects on mainly involve following aspects: (1) Controlling to reduce intestinal inflammation injury; (2) Regulation flora repair mucosal barrier; (3) Prevention ferroptosis epithelial cells. However, due complex role Nrf2/HO-1, more nuanced understanding exact mechanisms involved way forward future.
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11544 - 11544
Опубликована: Июль 17, 2023
MicroRNAs are small, noncoding molecules of about twenty-two nucleotides with crucial roles in both healthy and pathological cells. Their expression depends not only on genetic factors, but also epigenetic mechanisms like genomic imprinting inactivation X chromosome females that influence a sex-dependent manner onset, progression, response to therapy different diseases cancer. There is evidence correlation between miRNAs, sex, cancer solid tumors hematological malignancies; as an example, lymphomas, prevalence rate higher men than women, miR-142 “silenced” because its hypermethylation by DNA methyltransferase-1 it blocked normal activity regulating the migration cell. This condition corresponds clinical practice more aggressive tumor. In addition, treatment can have advantages from evaluation miRNAs expression; fact, estrogens hepatocellular carcinoma determines upregulation oncosuppressors miR-26a, miR-92, miR-122 and, consequently, apoptosis. The aim this review present exhaustive collection scientific data possible role sex differences through which cancerogenesis, autophagy, apoptosis cells diverse types tumors.
Язык: Английский
Процитировано
14
Oncology Letters, Год журнала: 2025, Номер 29(3)
Опубликована: Янв. 23, 2025
Lung adenocarcinoma (LUAD) is a prevalent malignant tumor of the respiratory tract. The Kelch like ECH associated protein 1 (KEAP1)/nuclear factor erythroid 2‑related 2 (NRF2)/heme oxygenase (HO‑1) axis serves pivotal role in occurrence and progression LUAD. present study aimed to identify specific genes regulated by mutations KEAP1/NRF2/HO‑1 investigate their prognostic potential LUAD, as well association with microenvironment. Immunohistochemistry was performed assess expression levels KEAP1, NRF2 HO‑1 LUAD tissues evaluate clinical pathology. Sequencing data information were obtained from Cancer Genome Atlas (TCGA)‑LUAD Gene Expression Omnibus (GSE68465) databases, whilst mutation sourced cBio Genomics Portal website. R package 'limma' Venn diagram utilized upregulated differentially expressed genes. Subsequently, model constructed using univariate Cox regression analysis 101 machine learning methods. A nomogram generated its efficacy evaluating survival among patients 'ImmuCellAI' 'oncoPredict' packages used compare differences immune cell infiltration immunotherapy between high‑ low‑risk groups, sensitivity chemotherapy drugs. Compared group negative expression, results revealed that positive exhibited advanced tumor, lymph node stages worse prognosis. predictive incorporating four (kynureninase, serpin family B member 5, insulin 4 γ‑aminobutyric acid type receptor subunit α3) based on mutation‑mediated (KNHMUGs). Risk score an independent for (hazard ratio, 1.038; 95% confidence interval, 1.034‑1.043; P<0.001). developed predict prognosis which validated reliable tool. higher infiltration, including CD4+ T, CD8+ natural killer (NK) NKT cells, compared high‑risk group. In addition, it demonstrated increased checkpoint inhibitory such cytotoxic T‑lymphocyte 4, T immunoreceptor Ig ITIM domains, hepatitis virus cellular lymphocyte protein. Moreover, displayed enhanced immunotherapy. Drug towards vinblastine, docetaxel cisplatin, whereas showed BMS_754807, SB505124_1194 JQ1_2172. conclusion, KNHMUGs‑based gene signature study, holds promise biomarker patient guiding treatment effectively assessing response
Язык: Английский
Процитировано
0
Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
0
Behavioural Brain Research, Год журнала: 2025, Номер unknown, С. 115545 - 115545
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0