Cell Biology and Toxicology,
Год журнала:
2024,
Номер
41(1)
Опубликована: Дек. 27, 2024
N-acetyltransferase
10
(NAT10)
is
a
member
of
the
Gcn5-related
(GNAT)
family
and
it
plays
crucial
role
in
various
cellular
processes,
such
as
regulation
cell
mitosis,
post-DNA
damage
response,
autophagy
apoptosis
regulation,
ribosome
biogenesis,
RNA
modification,
other
related
pathways
through
its
intrinsic
protein
acetyltransferase
activities.
Moreover,
NAT10
closely
associated
with
pathogenesis
tumors,
Hutchinson-Gilford
progeria
syndrome
(HGPS),
systemic
lupus
erythematosus,
pulmonary
fibrosis,
depression
host–pathogen
interactions.
In
recent
years,
mRNA
acetylation
has
emerged
prominent
focus
research
due
to
pivotal
regulating
stability
translation.
stands
out
sole
identified
modification
enzyme
responsible
for
acetylation.
There
remains
some
ambiguity
regarding
similarities
differences
NAT10's
actions
on
substrates.
While
involves
both
cases,
which
molecular
mechanism
epigenetic
there
are
significant
disparities
catalytic
mechanisms,
regulatory
pathways,
biological
processes
involved.
Therefore,
this
review
aims
offer
comprehensive
overview
acetyltransferase,
covering
basic
features,
functions,
roles
diseases.
Redox Biology,
Год журнала:
2024,
Номер
75, С. 103211 - 103211
Опубликована: Май 30, 2024
Ferroptosis
is
a
pervasive
non-apoptotic
form
of
cell
death
highly
relevant
in
various
degenerative
diseases
and
malignancies.
The
hallmark
ferroptosis
uncontrolled
overwhelming
peroxidation
polyunsaturated
fatty
acids
contained
membrane
phospholipids,
which
eventually
leads
to
rupture
the
plasma
membrane.
unique
that
it
essentially
spontaneous,
uncatalyzed
chemical
process
based
on
perturbed
iron
redox
homeostasis
contributing
process,
but
nonetheless
modulated
by
many
metabolic
nodes
impinge
cells'
susceptibility
ferroptosis.
Among
affecting
sensitivity,
several
have
emerged
as
promising
candidates
for
pharmacological
intervention,
rendering
ferroptosis-related
proteins
attractive
targets
treatment
numerous
currently
incurable
diseases.
Herein,
current
members
Germany-wide
research
consortium
focusing
research,
well
key
external
experts
who
made
seminal
contributions
this
rapidly
growing
exciting
field
gathered
provide
comprehensive,
state-of-the-art
review
Specific
topics
include:
basic
mechanisms,
vivo
relevance,
specialized
methodologies,
tools,
potential
contribution
disease
etiopathology
progression.
We
hope
article
will
not
only
established
scientists
newcomers
with
an
overview
multiple
facets
ferroptosis,
also
encourage
additional
efforts
characterize
further
molecular
pathways
modulating
ultimate
goal
develop
novel
pharmacotherapies
tackle
associated
-
or
caused
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 30, 2023
In
recent
years,
the
development
of
BMSCs-derived
exosomes
(EXO)
for
treatment
osteosarcoma
(OS)
is
a
safe
and
promising
modality
OS
treatment,
which
can
effectively
deliver
drugs
to
tumor
cells
in
vivo.
However,
differences
carried,
binding
EXOs
other
organs
limit
their
therapeutic
efficacy.
Therefore,
improving
OS-targeting
ability
BMSCs
developing
new
crucial
clinical
application
targeted
therapy
OS.In
this
study,
we
constructed
potential
nano
platform
by
modifying
using
bone-targeting
peptide
SDSSD
encapsulated
capreomycin
(CAP)
within
shell.
These
nanoparticles
(NPs)
showed
homologous
targeting
(BT-EXO)
significantly
promotes
cellular
endocytosis
vitro
accumulation
Furthermore,
our
results
revealed
that
NPs
induced
ferroptosis
prompting
excessive
reactive
oxygen
species
(ROS),
Fe2+
aggregation,
lipid
peroxidation
further
identified
anticancer
molecular
mechanism
as
transduced
Keap1/Nrf2/GPX4
signaling
pathway.
Also,
these
NP-directed
significant
inhibition
growth
vivo
with
no
side
effects.These
suggest
have
superior
activity
mouse
models
vivo,
providing
strategy
combining
ferroptosis-based
chemotherapy
OS.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 17, 2024
Abstract
N
4
-acetylcytidine
(ac
C)
is
a
highly
conserved
chemical
modification
widely
found
in
eukaryotic
and
prokaryotic
RNA,
such
as
tRNA,
rRNA,
mRNA.
This
significantly
associated
with
various
human
diseases,
especially
cancer,
its
formation
depends
on
the
catalytic
activity
of
N-acetyltransferase
10
(NAT10),
only
known
protein
that
produces
ac
C.
review
discusses
detection
techniques
regulatory
mechanisms
C
summarizes
correlation
tumor
occurrence,
development,
prognosis,
drug
therapy.
It
also
comments
new
biomarker
for
early
diagnosis
prognosis
prediction
target
Translational Oncology,
Год журнала:
2024,
Номер
45, С. 101934 - 101934
Опубликована: Апрель 30, 2024
N-acetyltransferase
10
(NAT10)
is
acknowledged
as
a
tumor
promoter
in
various
cancers
due
to
its
role
regulator
of
acetylation
modification.
Tumor-associated
macrophages
(TAMs)
play
pivotal
the
microenvironment
(TME).
However,
intercellular
communication
between
esophageal
squamous
cell
carcinoma
(ESCC)
cells
and
TAMs
involving
NAT10
remains
poorly
understood.
This
study
aimed
elucidate
regulatory
mechanism
modulating
macrophage
lipid
metabolism
polarization.
Experimental
evidence
was
derived
from
vitro
vivo
analyses.
We
explored
association
upregulated
ESCC
tissues,
polarization,
therapeutic
efficacy
PD-1.
Furthermore,
we
investigated
impact
methyltransferase
3
(METTL3)-induced
m6A
modification
on
increased
expression
cells.
Additionally,
examined
exosomal
stabilizing
fatty
acid
synthase
(FASN)
promoting
M2
polarization
through
mediating
ac4C
FASN.
Results
indicated
that
NAT10,
packaged
by
exosomes
cells,
promotes
facilitating
metabolism.
In
animal
studies
demonstrated
targeting
could
enhance
effect
PD-1
reprogramming.
Our
findings
offer
novel
insights
into
improving
treatment
targeting.
Abstract
N4‐acetylcytidine
(ac4C)
modification
is
a
crucial
RNA
widely
present
in
eukaryotic
RNA.
Previous
studies
have
demonstrated
that
ac4C
plays
pivotal
role
viral
infections.
Despite
numerous
highlighting
the
strong
correlation
between
and
cancer
progression,
its
detailed
roles
molecular
mechanisms
normal
physiological
processes
progression
remain
incompletely
understood.
This
review
first
outlines
key
regulatory
enzyme
mediating
modification,
N‐acetyltransferase
10
(NAT10),
including
critical
regulating
stability,
transcriptional
efficiency,
translational
fidelity.
Additionally,
it
systematically
summarizes
essential
functions
of
biological
processes,
stem
cell
fate
determination,
spermatogenesis
oogenesis,
embryonic
development,
cellular
senescence,
bone
remodeling.
Furthermore,
this
delves
into
central
malignant
proliferation,
cycle
arrest,
EMT,
drug
resistance,
death,
metabolism,
tumor
immunotherapy.
It
also
emphasizes
potential
NAT10
as
prognostic
biomarker
therapeutic
target
for
disease
treatment.
In
summary,
clarifies
multifaceted
both
health
explores
NAT10‐targeted
therapies
with
aim
advancing
research
improving
patient
outcomes.
