Biotechnology & Biotechnological Equipment,
Год журнала:
2024,
Номер
38(1)
Опубликована: Май 28, 2024
The
studies
of
rejuvenation
are
important
for
promoting
health
and
longevity,
preventing
age-related
diseases,
reducing
economic
burdens,
improving
quality
life
addressing
the
challenges
posed
by
an
aging
global
population.
This
review
explores
intersection
aging,
regeneration
bioelectric
fields
examining
emerging
role
membrane
potential
in
processes
like
cell
proliferation,
differentiation,
limb
potentially
aging.
Manipulation
opens
a
novel
dimension
to
landscape
offering
alternative
or
complementary
approach
partial
reprograming
method
presenting
exciting
possibilities
therapeutic
interventions
targeting
cellular
changes.
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 24, 2025
Abstract
Free
radicals,
characterized
by
the
presence
of
unpaired
electrons,
are
highly
reactive
species
that
play
a
significant
role
in
human
health.
These
molecules
can
be
generated
through
various
endogenous
processes,
such
as
mitochondrial
respiration
and
immune
cell
activation,
well
exogenous
sources,
including
radiation,
pollution,
smoking.
While
free
radicals
essential
for
certain
physiological
signaling
defense,
their
overproduction
disrupt
delicate
balance
between
oxidants
antioxidants,
leading
to
oxidative
stress.
Oxidative
stress
results
damage
critical
biomolecules
like
DNA,
proteins,
lipids,
contributing
pathogenesis
diseases.
Chronic
conditions
cancer,
cardiovascular
diseases,
neurodegenerative
disorders,
inflammatory
diseases
have
been
strongly
associated
with
harmful
effects
radicals.
This
review
provides
comprehensive
overview
characteristics
types
mechanisms
formation,
biological
impacts.
Additionally,
we
explore
natural
compounds
extracts
studied
antioxidant
properties,
offering
potential
therapeutic
avenues
managing
radical-induced
damage.
Future
research
directions
also
discussed
advance
our
understanding
treatment
radical-associated
Antioxidants,
Год журнала:
2023,
Номер
12(9), С. 1737 - 1737
Опубликована: Сен. 7, 2023
Hydrogen
sulfide
(H2S),
traditionally
recognized
as
a
toxic
gas,
has
emerged
critical
regulator
in
many
biological
processes,
including
oxidative
stress
and
cellular
homeostasis.
This
review
presents
an
exhaustive
overview
of
the
current
understanding
H2S
its
multifaceted
role
mammalian
functioning
management.
We
delve
into
sources
function
H2S,
mechanisms
underlying
homeostasis,
intricate
relationships
between
these
processes.
explore
evidence
from
recent
experimental
clinical
studies,
unraveling
biochemical
molecular
dictating
H2S’s
roles
modulating
responses
maintaining
The
implications
therapeutic
potential
conditions
characterized
by
dysregulation
disrupted
homeostasis
are
discussed,
highlighting
emerging
significance
health
disease.
Finally,
this
underscores
challenges,
controversies,
future
directions
field,
emphasizing
need
for
further
research
to
harness
agent
diseases
associated
with
homeostatic
imbalance.
Through
review,
we
aim
emphasize
pivotal
function,
encouraging
exploration
burgeoning
area
research.
Phytotherapy Research,
Год журнала:
2023,
Номер
37(12), С. 5700 - 5723
Опубликована: Сен. 25, 2023
Abstract
Galangin
is
an
important
flavonoid
with
natural
activity,
that
abundant
in
galangal
and
propolis.
Currently,
various
biological
activities
of
galangin
have
been
disclosed,
including
anti‐inflammation,
antibacterial
effect,
anti‐oxidative
stress
aging,
anti‐fibrosis,
antihypertensive
effect.
Based
on
the
above
bioactivities,
more
attention
has
paid
to
role
neurodegenerative
diseases,
rheumatoid
arthritis,
osteoarthritis,
osteoporosis,
skin
cancer.
In
this
paper,
sources,
pharmacokinetics,
therapeutic
potential
against
diseases
were
systematically
reviewed
by
collecting
summarizing
relevant
literature.
addition,
molecular
mechanism
new
preparation
treatment
related
are
also
discussed,
broaden
application
prospect
provide
reference
for
its
clinical
application.
Furthermore,
it
should
be
noted
current
toxicity
studies
insufficient,
evidence
needed
support
possibility
as
a
functional
food.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 670 - 670
Опубликована: Май 22, 2024
Given
the
ongoing
rise
in
occurrence
of
allergic
disorders,
alterations
dietary
patterns
have
been
proposed
as
a
possible
factor
contributing
to
emergence
and
progression
these
conditions.
Currently,
there
is
significant
focus
on
development
therapies
that
utilize
natural
compounds
possessing
anti-allergy
properties.
Dietary
polyphenols
plant
metabolites
intensively
researched
due
their
well-documented
anti-inflammatory,
antioxidant,
immunomodulatory
characteristics,
making
them
one
most
prominent
bioactive
chemicals.
This
study
seeks
discuss
in-depth
mechanisms
by
which
molecules
may
exert
anti-allergic
effects,
namely
through
capacity
diminish
allergenicity
proteins,
modulate
immune
responses,
modify
composition
gut
microbiota.
However,
further
investigation
required
fully
understand
effects.
paper
examines
existing
evidence
from
experimental
clinical
studies
supports
idea
different
polyphenols,
such
catechins,
resveratrol,
curcumin,
quercetin,
others,
can
reduce
inflammation,
relieve
symptoms
food
allergy,
asthma,
atopic
dermatitis,
rhinitis,
prevent
response.
In
summary,
possess
properties
be
utilized
for
developing
both
preventative
therapeutic
strategies
targeting
The
also
discusses
constraints
investigating
broad
usage
well
potential
avenues
future
research.
AJP Heart and Circulatory Physiology,
Год журнала:
2023,
Номер
326(2), С. H317 - H333
Опубликована: Дек. 1, 2023
Mitochondria
are
cellular
organelles
critical
for
ATP
production
and
particularly
relevant
to
cardiovascular
diseases
including
heart
failure,
atherosclerosis,
ischemia-reperfusion
injury,
cardiomyopathies.
With
advancing
age,
even
in
the
absence
of
clinical
disease,
mitochondrial
homeostasis
becomes
disrupted
(e.g.,
redox
balance,
DNA
damage,
oxidative
metabolism,
quality
control).
Mitochondrial
dysregulation
leads
accumulation
damaged
dysfunctional
mitochondria,
producing
excessive
reactive
oxygen
species
perpetuating
dysfunction.
In
addition,
DNA,
cardiolipin,
Translational Stroke Research,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 26, 2023
Abstract
Subarachnoid
hemorrhage
(SAH)
is
a
type
of
stroke
with
high
disability
and
mortality
rate.
Apoptosis
caused
by
massive
damage
to
mitochondria
in
neuron
cells
inflammatory
responses
extracellular
ATP
lead
poor
outcomes.
USP30
deubiquitinating
enzyme
that
inhibits
mitophagy,
resulting
failure
remove
damaged
timely
manner
after
SAH;
nevertheless,
the
pathway
through
which
mitophagy
unknown.
This
study
evaluated
neuroprotective
role
possible
molecular
basis
inhibiting
attenuate
SAH-induced
EBI
promoting
neuronal
mitophagy.
We
used
an
vitro
model
hemoglobin
exposure
vivo
intravascular
perforation.
Increased
expression
was
found
SAH
vitro,
inhibition
mice
treated
MF094
resulted
significant
improvement
neurological
injury
response
mediated
good
outcomes,
suggesting
effect
inhibition.
In
cultured
neurons,
promoted
ubiquitination
modification
mitochondrial
fusion
protein
2
(MFN2)
E3
ubiquitin
ligase
(Parkin),
separating
from
healthy
network
prompting
causing
early
clearance
intracellular
mitochondria,
reducing
onset
apoptosis.
The
environment
meliorated,
reversing
conversion
microglia
pro-inflammatory
phenotype
injury.
had
no
autophagy-promoting
on
structurally
functionally
sound
did
not
inhibit
normal
production.
findings
suggest
has
clear
mitochondria.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(1), С. 56 - 56
Опубликована: Янв. 6, 2025
The
imbalance
in
the
production
of
reactive
oxygen
species
(ROS)
with
endogenous
antioxidant
capacity
leads
to
oxidative
stress,
which
drives
many
disorders,
especially
skin.
In
such
conditions,
supplementing
exogenous
antioxidants
may
help
body
prevent
negative
effect
ROS.
However,
skin,
as
outermost
barrier
body,
provides
a
perfect
barricade,
making
delivery
complicated.
Several
strategies
have
been
developed
enhance
penetration
through
one
is
nanotechnology.
This
review
focuses
on
utilizing
several
nanocarrier
systems,
including
nanoemulsions,
liposomes,
solid
lipid
nanoparticles
(SLNs),
nanostructured
carriers
(NLCs),
and
polymeric
nanoparticles,
for
transporting
into
We
also
reveal
ROS
formation
skin
role
therapy,
well
natural
sources
antioxidants.
Furthermore,
we
discuss
clinical
application
topical
therapy
concomitantly
current
status
using
nanotechnology
deliver
will
accelerate
advancement
therapy.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 10, 2025
Oxidative
stress
is
widely
acknowledged
as
a
key
pathogenic
mechanism
in
diabetic
nephropathy
(DN).
In
recent
years,
the
role
of
oxidative
DN
has
garnered
increasing
attention.
However,
no
bibliometric
analysis
yet
been
conducted
on
relationship
between
and
DN.
This
study
aims
to
systematically
analyze
relevant
literature,
identify
trends
research,
assess
current
hotspots,
predict
future
directions.
We
retrieved
literature
related
from
Web
Science
Core
Collection
database.
analyzed
data
publication
volume,
countries/regions,
institutions,
journals,
keywords,
other
metrics
using
VOSviewer,
Bibliometrix
R
package,
CiteSpace.
From
2014
2024,
total
4076
publications
were
published
across
755
showing
consistent
upward
trend
each
year.
China
United
States
are
leading
contributors
this
field
demonstrate
close
collaborative
efforts.
The
top
by
country,
institution,
journal,
author
include:
(1919
publications),
Jilin
University
Central
South
(69
each),
BIOMEDICINE
&
PHARMACOTHERAPY
(117
Prof.
Sun
Lin
(33
publications).
most
frequent
keyword
"oxidative
stress"
(3683
occurrences).
co-citation
analysis,
Alicic
RZ's
2017
was
cited
(144
citations).
These
findings
highlight
critical
importance
investigating
pathogenesis
perspective.
demonstrates
steady
increase
research
since
2014,
highlighting
its
central
Future
should
focus
molecular
mechanisms
explore
therapeutic
potential,
provide
new
strategies
for
prevention
treatment
