Food Science & Nutrition,
Год журнала:
2024,
Номер
13(1)
Опубликована: Дек. 20, 2024
While
fructose
is
a
key
dietary
component,
concerns
have
been
raised
about
its
potential
risks
to
the
liver.
This
study
aimed
assess
quercetin's
protective
effects
against
fructose-induced
mouse
hepatic
steatosis.
Thirty-two
male
C57BL/6J
mice
were
randomly
allocated
into
four
groups:
control,
high
diet
(HFrD),
HFrD
supplemented
with
low-dose
quercetin
(HFrD+LQ),
and
high-dose
(HFrD+HQ).
Biochemical,
pathological,
immune,
metabolic
parameters
assessed.
Quercetin
treatment
significantly
reduced
liver
fat
percentages
in
on
diet,
most
notable
reduction
observed
HFrD+HQ
group.
Histological
examination
confirmed
this
reduction,
revealing
diminished
lipid
droplets
decreased
inflammation
steatosis
hepatocytes.
Compared
group,
interleukin-1
β
tumor
necrosis
factor
alpha
decreased,
serum
aspartate
aminotransferase
concentrations
markedly
reduced,
blood
high-density
lipoprotein
substantially
elevated
after
intervention
(
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 4, 2024
This
study
was
divided
into
two
parts.
The
first
part
involved
the
isolation,
and
detection
of
prevalence
antimicrobial
resistance
profile
Aeromonas
hydrophila,
Pseudomonas
aeruginosa,
Vibrio
species
from
Nile
tilapia
fish
marine
aquatic
water.
One
hundred
freshly
dead
were
collected
freshwater
aquaculture
farms
located
in
Al-Abbassah
district,
Sharkia
Governorate,
100
samples
water
Port
Said.
second
focused
on
determining
vitro
inhibitory
effect
dual-combination
AgNPs-H2O2
bacterial
growth
its
down
regulatory
crucial
virulence
factors
using
RT-PCR.
highest
levels
A.
hydrophila
P.
aeruginosa
detected
43%,
34%
samples,
respectively.
Meanwhile,
level
found
37%
samples.
Additionally,
most
isolated
exhibited
a
multi-drug
profile.
MIC
MBC
results
indicated
bactericidal
AgNPs-H2O2.
Furthermore,
transcriptional
modulation
virulence-associated
genes
resulted
significant
down-regulation
aerA,
exoU,
trh
spp.,
findings
this
suggest
effectiveness
against
drug
resistant
pathogens
related
to
aquaculture.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12091 - 12091
Опубликована: Ноя. 11, 2024
The
main
goal
of
this
systematic
review
on
the
flavonol
class
secondary
metabolite
quercetin
is
to
evaluate
and
summarize
existing
research
quercetin's
potential
health
benefits,
therapeutic
properties,
effectiveness
in
disease
prevention
treatment.
In
addition
evaluating
for
drug
development
with
fewer
side
effects
lower
toxicity,
type
attempts
collect
scientific
evidence
addressing
roles
as
an
antioxidant,
anti-inflammatory,
antibacterial,
anticancer
agent.
first
part,
we
analyze
various
flavonoid
compounds,
focusing
their
chemical
structure,
classification,
natural
sources.
We
highlight
most
recent
biological
activities
reported
literature.
Among
these
pay
special
attention
quercetin,
detailing
its
physicochemical
process
biosynthesis
plants.
also
present
sources
emphasize
such
antioxidant
anti-inflammatory
effects.
Additionally,
discuss
methods
enhance
bioavailability,
analyzing
latest
effective
delivery
systems
based
quercetin.
PeerJ,
Год журнала:
2024,
Номер
12, С. e17094 - e17094
Опубликована: Март 29, 2024
Liver
disease
is
a
common
and
serious
threat
to
human
health.
The
progression
of
liver
diseases
influenced
by
many
physiologic
processes,
including
oxidative
stress,
inflammation,
bile
acid
metabolism,
autophagy.
Various
factors
lead
the
dysfunction
these
processes
basing
on
different
pathogeny,
pathology,
clinical
manifestation,
pathogenesis,
are
grouped
into
categories.
Specifically,
Sirtuin1
(SIRT1),
member
sirtuin
protein
family,
has
been
extensively
studied
in
context
injury
recent
years
confirmed
significant
role
disease.
SIRT1
found
play
critical
regulating
key
injury.
Further,
seems
cause
divers
outcomes
types
diseases.
Recent
studies
have
showed
some
therapeutic
strategies
involving
modulating
SIRT1,
which
may
bring
novel
target.
To
elucidate
mechanisms
underlying
sirtuin1
its
potentiality
as
target,
this
review
outlines
signaling
pathways
associated
with
injury,
discusses
advances
targeting
Biological Research,
Год журнала:
2024,
Номер
57(1)
Опубликована: Июль 9, 2024
Diabetic
neuropathy
(DN)
is
recognized
as
a
significant
complication
arising
from
diabetes
mellitus
(DM).
Pathogenesis
of
DN
accelerated
by
endoplasmic
reticulum
(ER)
stress,
which
inhibits
autophagy
and
contributes
to
disease
progression.
Autophagy
highly
conserved
mechanism
crucial
in
mitigating
cell
death
induced
ER
stress.
Chrysin,
naturally
occurring
flavonoid,
can
be
found
abundantly
honey,
propolis,
various
plant
extracts.
Despite
possessing
advantageous
attributes
such
being
an
antioxidant,
anti-allergic,
anti-inflammatory,
anti-fibrotic,
anticancer
agent,
chrysin
exhibits
limited
bioavailability.
The
current
study
aimed
produce
more
bioavailable
form
discover
how
administering
could
alter
the
Alloxan
male
rats.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
65(4), С. 627 - 646
Опубликована: Дек. 7, 2023
Epigenetics
regulates
gene
expression
and
play
significant
roles
across
diverse
disease
states.
mechanisms,
including
DNA
methylation,
histone
modifications,
microRNAs/lncRNA,
N6-methyladenosine
(m6A)
RNA
elicit
heritable
but
reversible
modifications
in
without
modifying
the
sequence.
Recent
research
suggests
that
certain
natural
phytochemicals
with
chemopreventive
properties
have
potential
to
function
as
epigenetic
regulators.
Quercetin,
a
derivative
of
flavonoid
glycosides
constituent
human
diet,
is
linked
variety
health
benefits
anti-inflammatory,
anticancer
activity,
antiapoptotic,
antihypertensive,
neuroprotective
effects.
findings
suggest
quercetin
possesses
ability
modulate
canonical
biochemical
signaling
pathways
exert
an
impact
on
networks.
This
review
aims
synthesize
most
recent
elucidate
biological
effects
its
influence
vitro
vivo
models
via
mechanisms.
In
light
our
findings,
it
evident
exemplary
instance
naturally
derived
phytochemicals,
which
can
be
effectively
employed
pivotal
functional
foods
dietary
supplements
aimed
at
amelioration
various
ailments.
More
specifically,
mechanism
action
involves
alteration
targets.
Veterinary Medicine and Science,
Год журнала:
2024,
Номер
10(3)
Опубликована: Март 20, 2024
Lipopolysaccharide
(LPS)
can
induce
systemic
inflammation
and
affect
the
growth
development
of
poultry.
As
a
kind
traditional
Chinese
medicine,
polysaccharide
Atractylodes
macrocephala
Koidz
(PAMK)
effectively
improve
performance
animals
immunity
animal
bodies.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 24, 2024
The
liver
is
the
largest,
important
organ
and
site
for
essential
biochemical
reactions
in
human
body.
It
has
function
to
detoxify
toxic
substances
synthesize
useful
biomolecules.
Liver
diseases
related
complications
represent
a
significant
source
of
morbidity
mortality
worldwide,
creating
substantial
economic
burden.
Oxidative
stress,
excessive
inflammation,
dysregulated
energy
metabolism
significantly
contributed
diseases.
Therefore,
discovery
novel
therapeutic
drugs
treatment
are
urgently
required.
For
centuries,
flavonoids
their
preparations
which
have
beneficial
health
effects
chronic
been
used
treat
various
illnesses.
Flavonoids
mainly
include
flavones,
isoflavones,
flavanols,
dihydroflavones,
dihydroflavonols,
anthocyanins
chalcones.
primary
objective
this
review
assess
efficacy
safety
flavonoids,
from
clinical
point
view
considering
clinically
relevant
end-points.
We
summarized
recent
progress
research
hepatoprotective
molecular
mechanisms
different
bioactive
ingredients
also
outlined
networks
underlying
signaling
pathways.
Further
pharmacology
toxicology
will
contribute
development
natural
products
derivatives
as
medicines
with
alluring
prospect
application.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 24, 2025
Introduction
Enterococcus
faecalis
,
a
common
inhabitant
of
the
feline
gastrointestinal
tract,
has
emerged
as
significant
pathogen
causing
urinary
tract
infections
(UTIs)
in
domestic
cats.
The
rise
multidrug-resistant
E.
strains
and
their
propensity
to
form
biofilms
pose
challenges
treatment.
This
study
investigated
antibacterial
antibiofilm
activities
hexagonal
zinc
oxide
nanoparticles
(ZnONPs)
alone
combination
with
streptomycin
Moringa
oleifera
leaf
extract
(MOLe)
against
isolates
from
UTIs.
Methods
Antimicrobial
susceptibility
testing
was
performed
using
Kirby-Bauer
disk
diffusion
method.
Biofilm
formation
assessed
crystal
violet
assay,
biofilm-associated
genes
(
sprE
gel
E,
fsr
ABC)
were
detected
by
PCR.
ZnONPs,
Str/ZnONPs
(streptomycin-loaded
ZnONPs),
Str/MOLe@ZnONPs
(streptomycin
MOLe-loaded
ZnONPs)
characterized
FTIR,
DLS,
TEM,
SEM.
synthesized
evaluated
through
time-kill
assays,
well
gene
expression
analysis.
Results
A
high
prevalence
multidrug
resistance
observed
among
isolates,
ampicillin,
vancomycin,
streptomycin.
Characterization
studies
revealed
successful
encapsulation
MOLe
within
ZnONPs.
In
vitro
assays
demonstrated
that
exhibited
potent
tested
strains,
significantly
reducing
bacterial
growth
biofilm
formation.
Discussion
emergence
necessitates
development
novel
therapeutic
strategies.
demonstrates
promising
potential
particularly
those
loaded
MOLe,
combating
biofilm-forming
.
synergistic
effects
combined
formulation
may
offer
approach
overcome
antibiotic
improve
treatment
outcomes
UTIs
