State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives

Pharmaceuticals, Год журнала: 2024, Номер 17(4), С. 483 - 483

Опубликована: Апрель 10, 2024

Background: Despite some evidence supporting the synergy concept, commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has yet be unambiguously and explicitly studied. Study aim: The study aimed reveal molecular interactions situ host cells response botanical hybrid preparations (BHP) intervention justify benefits implementing BHP clinical practice. Results: This prospective literature review provides results recent network pharmacology studies Rhodiola rosea L. (Arctic root) with other plants, including Withania somnifera (L.) Dunal (ashwagandha), (Camellia sinensis Kuntze (green tea), Eleutherococcus senticosus (Rupr. Maxim.) Maxim. (eleuthero), Schisandra chinensis (Turcz.) Baill. (schisandra), Leuzea carthamoides (Willd.) DC., caffeine, Cordyceps militaris L., Ginkgo biloba L.(ginkgo), Actaea racemosa (black cohosh), Crocus sativus (saffron), L-carnosine. Conclusions: most important finding from was interaction ingredients, revealing unexpected new pharmacological activities unique specific BHP. Some show superior compared mono-drugs. At same time, a priori-designed fail, presumably antagonistic crosstalk between targets within networks involved cellular overall organisms intervention. Network help predict at discovering indications unpredicted adverse events.

Язык: Английский

---

The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Сен. 30, 2024

Neuroinflammation in response to environmental stressors is an important common pathway a number of neurological and psychiatric disorders. Responses immune-mediated stress can lead epigenetic changes the development neuropsychiatric Isothiocyanates (ITC) have shown promise combating oxidative inflammation nervous system as well organ systems. While sulforaphane from broccoli most widely studied ITC for biomedical applications, their precursor glucosinolates are found many species cruciferous other vegetables including moringa. In this review, we examine both clinical pre-clinical studies on amelioration disorders (neurodevelopmental, neurodegenerative, other) 2018 present, documentation protocols several ongoing studies. During time, there been 16 (9 randomized controlled trials), which reported effect autism spectrum disorder schizophrenia. We also review over 80 preclinical examining treatment brain-related dysfunctions The evidence date reveals great potential treating these conditions with minimal toxicity. authors call well-designed trials further translation potent phytochemicals into therapeutic practice.

Язык: Английский

---

Botanical hybrid preparations (BHP) in phytomedicine and phytotherapy research: background and perspectives

Опубликована: Март 15, 2024

Background: The commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has not been systematically studied despite some evidence supporting the synergy concept. Study aim: study aimed reveal molecular interactions situ host cells response intervention BHP and justify benefits implementing clinical practice. Results: This overview provides results recent network pharmacology studies botanical herbal preparations (BHP) Rhodiola with other plants, including Ashwagandha, Green Tea, Eleutherococcus, Schisandra, Leuzea, Caffeine, Cordyceps, Gingko, Black Cohosh, saffron, L-carnosine. Conclusions: most important finding from was interaction ingredients, revealing unexpected new pharmacological activities unique specific BHP. Some show superior compared mono-drugs. At same time, a priori-designed fail, presumably antagonistic crosstalk between targets within networks involved cellular overall organisms on intervention. Network help predict discover indications unpredicted adverse events.

Язык: Английский

---

Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 31, 2025

Neurological disorders pose significant global public health challenges, with a rising prevalence and complex pathophysiological mechanisms that impose substantial social economic burdens. Traditional Chinese Medicine (TCM), its holistic approach multi-target effects, has gained increasing attention in the treatment of neurological diseases. This review explores bioactive compounds derived from herbal plants, focusing on their action, underlying pathways, potential applications functional food development. The highlights neuroprotective properties flavonoids, alkaloids, polysaccharides, polyphenols found key TCM herbs such as Scutellaria baicalensis , Salvia miltiorrhiza Ligusticum chuanxiong Gastrodia elata . These have demonstrated anti-inflammatory, antioxidant, neurogenic making them promising candidates for prevention conditions, including Alzheimer’s disease (AD), Parkinson’s (PD), depression. Furthermore, synergistic effects formulations targeting multiple signaling pathways offer advantages over single-target therapies, especially combating neurodegenerative also discusses challenges future directions integrating these into foods dietary supplements, aiming to improve enhance clinical outcomes. Ultimately, this work aims provide valuable insights TCM-based interventions promoting well-being addressing burden disorders.

Язык: Английский

---

Neuroprotective role of Epigallocatechin-3-Gallate, Albeginin and Melanoxetin in Alzheimer's Disease

Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100740 - 100740

Опубликована: Янв. 1, 2025

Язык: Английский

---

Versatility of Caenorhabditis elegans as a Model Organism for Evaluating Foodborne Neurotoxins and Food Bioactive Compounds in Nutritional Neuroscience

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 25, 2025

Язык: Английский

---

Quercetin as a Complementary Therapy in Substance Use Disorder: A Narrative Review

Majallah-i dānishgāh-i ̒ulum-i pizishkī-i Kirmān., Год журнала: 2025, Номер 32, С. 3816 - 3816

Опубликована: Март 2, 2025

Substance use disorder (SUD) is a pervasive public health concern characterized by compulsive drug despite adverse consequences. SUD treatment strategies aim to help addicts stop obsessively seeking and consuming drugs. These approaches could be provided in variety of venues, utilizing range behavioral pharmacological techniques. Emerging research explores alternative treatments for SUD, including the medicinal plants. Quercetin, natural flavonoid present various fruits vegetables, exhibits promising properties. This naturally occurring pharmaceutical component has shown promise as preventive measure against wide disorders. It shields user neurodegeneration, oxidative stress, inflammation, offering hope central nervous-system-related treatment. Regarding substance abuse, quercetin shows substantial promise. demonstrates ability mitigate effects substances, methamphetamine, nicotine, morphine, heroin, alcohol, through mechanisms, antioxidant, antiinflammatory, neuroprotective pathways. review synthesizes recent evidence supporting complementary approach conventional addiction treatments.

Язык: Английский

---

Anxiolytic, Antidepressant and Healthy Sleep-Promoting Potential of Rosmarinic Acid: Mechanisms and Molecular Targets

Neuropsychiatric Disease and Treatment, Год журнала: 2025, Номер Volume 21, С. 641 - 661

Опубликована: Март 1, 2025

The etiology of psychiatric disorders is complex and results from intricate interactions among multiple neurobiological, psychological, environmental, genetic factors. Furthermore, the roles gut microbiome dyshomeostasis in their pathogeneses are just beginning to be uncovered, adding another level complexity. In recent years, significant efforts have been directed toward discovering multimodal yet safe therapeutics counteract psychological deficits. Rosmarinic acid (RA), a polyphenol found several medicinal herbs, has received considerable attention as potential multifaceted therapeutic agent, particularly for neuropsychiatric conditions. order critically evaluate this aspect, data was compiled consolidated after extensive searches on scholarly databases like PubMed, Google Scholar, Web Science. Peer-reviewed publications which focused RA agent were included regardless year publication country origin. Based pre-clinical clinical evidence, review delves into various mechanistic aspects antidepressant, anxiolytic, sleep-promoting functions RA. beneficial effects gut-microbiome-brain (GMB) axis implications regulation neuroprotective pathways also discussed, with particular focus exploiting them ameliorate Our assessment indicated that neuroprotectant against conditions beneficially influences plethora targets related redox, inflammatory, synaptic, cell death, neurotrophic, signaling pathways. As dietary may relevant favorably altering GMB axis, indicating its prospects adjuvant regulating pathogenic mechanisms underlying However, more studies required ascertain neuromodulatory actions neuronal pathophysiologies, including ailments.

Язык: Английский

---

Astaxanthin Mitigates ADHD Symptoms in Spontaneously Hypertensive Rats via Dopaminergic Modulation and Brain–Gut Axis Regulation

Molecules, Год журнала: 2025, Номер 30(7), С. 1637 - 1637

Опубликована: Апрель 7, 2025

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder that significantly impacts learning, daily functioning, and personal development. Astaxanthin (ASTA), naturally occurring antioxidant, has garnered interest as potential therapeutic agent for various diseases, particularly in mitigating oxidative stress. This study explores novel application of ASTA the context ADHD, aiming to investigate its effects underlying mechanisms. Spontaneously hypertensive rats (SHRs), widely used ADHD model animals, were treated with (50/100 mg/kg/day) three weeks, 5 mg/kg/day atomoxetine (ATO) positive, Wistar Kyoto (WKY) control. Behavioral improvements assessed using open field test (OFT) Morris water maze (MWM). Biochemical analyses conducted evaluate changes levels neurotrophic factors, while histological examinations performed assess neuroprotective effects. Additionally, role brain–gut axis was investigated. The behavioral symptoms hyperactivity, anxiety, impaired spatial memory animals mitigated by ASTA. improvement primarily attributed restoration neurotransmitter levels, dopamine (DA), achieved through modulation several critical components within system, including receptor 1 (DR1), transporter (DAT), tyrosine hydroxylase (TH), synaptic-associated protein 25 (SNAP-25). regulating serotonin (SERT) glial cell-derived factor (GDNF) supports recovery facilitates optimal brain Furthermore, cerebellar cells protected, structure intestinal microbiota regulated. can mitigate SHR dopaminergic multiple neurotransmitters, neuro-intestinal environment, which establishes promising nutraceutical candidate adjunctive therapy pediatric ADHD.

Язык: Английский

---

Evaluation of antioxidant properties, sensory profile of encapsulated spice oleoresins and molecular docking studies for the anti-depressive potential of their active components

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106545 - 106545

Опубликована: Апрель 1, 2025

Язык: Английский

---