Dual sources of melatonin and evidence for different primary functions

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 14, 2024

This article discusses data showing that mammals, including humans, have two sources of melatonin exhibit different functions. The best-known source melatonin, herein referred to as Source #1, is the pineal gland. In this organ, production circadian with maximal synthesis and release into blood cerebrospinal fluid occurring during night. Of total amount produced in we speculate less than 5% synthesized by rhythm has primary function influencing clock at level suprachiasmatic nucleus (the CSF melatonin) clockwork all peripheral organs via receptor-mediated actions. A second (Source # 2) from multiple tissues throughout body, probably being mitochondria these cells. constitutes bulk mammals concerned metabolic regulation. review emphasizes action determining re-dox homeostasis, but it other critical effects well. Extrapineal does not a released acts locally its cell origin possibly paracrine matter on adjacent factors control/influence extrapineal sites are unknown. We propose concentration cells determined subcellular redox state may be inducible under stressful conditions plant

Язык: Английский

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Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?

Nutrients, Год журнала: 2024, Номер 16(10), С. 1422 - 1422

Опубликована: Май 8, 2024

Breastfeeding is the most appropriate source of a newborn’s nutrition; among plethora its benefits, modulation circadian rhythmicity with melatonin as potential neuroendocrine transducer has gained increasing interest. Transplacental transfer assures provision for fetus, who devoid secretion. Even after birth, neonatal pineal gland not able to produce rhythmically several months (with an even more prolonged deficiency following preterm birth). In this context, human breast milk constitutes main natural melatonin: diurnal dynamic changes, acrophase early midnight, and changes in concentrations according gestational age during different stages lactation have been reported. Understudied thus far are factors impacting on (changes in) content their clinical significance chronobiological adherence neonate: maternal well environmental aspects be investigated detail guide nursing mothers optimal feeding schedules which probably means synchronized instead mistimed practice. This review aims thought-provoking regarding critical role chrononutrition breastfeeding, highlighting entrainment therefore optimizing (neuro)developmental outcomes setting.

Язык: Английский

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Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer

Nutrients, Год журнала: 2024, Номер 16(8), С. 1236 - 1236

Опубликована: Апрель 21, 2024

Inflammatory bowel disease (IBD), a continuum of chronic inflammatory diseases, is tightly associated with immune system dysregulation and dysbiosis, leading to inflammation in the gastrointestinal tract (GIT) multiple extraintestinal manifestations. The pathogenesis IBD not completely elucidated. However, it an increased risk colorectal cancer (CRC), which one most common malignancies. In both CRC, complex interplay occurs between gut microbiota (GM), alteration GM composition. Melatonin, neuroendocrine hormone, was found be involved this interplay, especially since present high amounts gut, some protective effects. Actually, melatonin enhances integrity intestinal mucosal barrier, regulates response, alleviates inflammation, attenuates oxidative stress. Thereby, authors summarize multifactorial interaction focusing on new findings related mechanisms action addition its documented positive outcomes treatment these two pathologies possible future perspectives use as adjuvant therapy.

Язык: Английский

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Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits

Biology, Год журнала: 2025, Номер 14(2), С. 143 - 143

Опубликована: Янв. 30, 2025

Melatonin is indispensable for the homeostasis of plants and animals. In humans, it can help prevent or be an adjuvant treatment several diseases mainly related to immune system, inflammation, oxidative stress. Moreover, a melatonin-rich diet linked health benefits, such as regulation circadian rhythm, immunological epilepsy control, delaying aging process, diminishing hormones cancer. This review aimed show effects melatonin in beyond its traditional use. The results showed present scavenging free radicals, reducing inflammatory cytokines, modulating system. improve insulin resistance, blood pressure, LDL-c, adipose tissue mass, adhesion molecules, endothelial impairment, plaque formation. These result neuro- cardioprotection, improvement liver diseases, rheumatoid arthritis, dermatitis, COVID-19, polycystic ovaries, sepsis. We conclude that plant benefit patients with many besides sleep problems neurodegeneration. Plant may more cost-effective fewer adverse events than synthetic. However, clinical trials should performed adequate doses, formulation, time.

Язык: Английский

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Melatonin Interventions in Autism Spectrum Disorder: Sleep Regulation, Behavioral Outcomes, and Challenges Across the Lifespan

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

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Linkage of circadian rhythm disruptions with Alzheimer’s disease and therapeutic interventions

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Bioactive Peptides in Dairy Milk: Highlighting the Role of Melatonin

Biomolecules, Год журнала: 2024, Номер 14(8), С. 934 - 934

Опубликована: Авг. 1, 2024

Melatonin, an endogenous indolamine derived from tryptophan, is primarily synthesized by the pineal gland in mammals and regulated a complex neural system. Its release follows circadian rhythm, which crucial for regulating physiological processes response to light-dark cycles both humans animals. In this review, we report that presence of hormone bovine milk, with significant differences concentration between daytime nighttime milking, has increased interest milk as natural source bioactive molecules. Melatonin lowers cortisol levels at night, reduces body temperature blood pressure, coinciding decreased alertness performance, acts antioxidant anti-inflammatory agent, modulates immune system, offers neuroprotective benefits, supports gastrointestinal health scavenging free radicals reducing oxidative stress dairy cows. Many factors influence melatonin, such intensity artificial lighting during frequency milkings, yield, genetic Nocturnal milking under low-intensity light boosts potentially damage mastitis risk. Additionally, ultra-high (UHT) treatment does not significantly affect melatonin content milk. However, further research on its stability processing storage ensuring product efficacy. some countries, naturally elevated already commercialized aid sleep. Thus, melatonin-rich may be promising alternative synthetic supplements promoting better sleep overall well-being.

Язык: Английский

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Melatonin mitigates manganese-induced neural damage via modulation of gut microbiota-metabolism in mice

The Science of The Total Environment, Год журнала: 2024, Номер 923, С. 171474 - 171474

Опубликована: Март 5, 2024

Язык: Английский

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Pathophysiological features of acute liver failure caused by cholestasis [

Fìzìologìčnij žurnal, Год журнала: 2024, Номер 70(4), С. 80 - 94

Опубликована: Июнь 14, 2024

Acute liver failure is a syndrome that occurs in 20-59% of patients with pathology and one the main causes death 40% mechanical jaundice benign origin more than 70% cases tumor obstruction biliary tract cancer caput pancreas. In most cases, consequence acute damage (viral or drug-induced). Still, it can occur longterm obstructive jaundice, be first manifestation Wilson’s disease, autoimmune chronic hepatitis, superinfection hepatitis D virus against background B. The aim work was to study pathophysiological features development bile outflow disorders. pathogenesis caused by cholestasis based on hepatocytes due impaired blood circulation liver, as well toxic effect parenchyma both etiological factors themselves their metabolites. week from onset symptoms very important usually accompanied systemic inflammatory response significant consequences. At same time, influencing results treatment at different points time are combination critical functional reserve nature severity damage. case syndrome, there further increase inflammation, which has leads other organs. Under these circumstances, understanding course makes possible carry out necessary diagnostic measures offer appropriate therapy.

Язык: Английский

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Breastfeeding in the prevention of long-term consequences of neuropsychiatric pathology in offspring with gestational diabetes mellitus

Journal of obstetrics and women s diseases, Год журнала: 2024, Номер 73(4), С. 107 - 118

Опубликована: Окт. 7, 2024

This literature review summarizes modern concepts of gestational diabetes mellitus as an independent risk factor for the development long-term neuropsychiatric diseases in offspring and mechanisms their programming this complication pregnancy absence protective role maternal melatonin a consequence chronodestruction. The article presents data on composition breast milk participation its endogenous melatonin, microRNAs, long non-coding RNAs, stem cells, microbiome reprogramming epigenetic disorders result adverse effects antenatal period, which helps to reduce likelihood developing pathology later life. It is emphasized that breastfeeding during first six months life later, along with complementary foods under age two years older, exclusively physiological unsurpassed method preventing consequences impaired brain mellitus.

Язык: Английский

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