Physiological and Molecular Plant Pathology, Год журнала: 2025, Номер unknown, С. 102570 - 102570
Опубликована: Янв. 1, 2025
Язык: Английский
Antioxidants, Год журнала: 2025, Номер 14(1), С. 108 - 108
Опубликована: Янв. 18, 2025
The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments several brain diseases. Mitochondrial can arise from genetic mutations, ischemic events, hypoxia, other environmental factors. This article highlights critical role progression diseases discusses need targeted therapeutic strategies attenuate damage, restore enhance neuroprotection.
Язык: Английский
Процитировано
1
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 23, 2025
Oxidative stress is a crucial pathophysiological mechanism in chronic diseases and mortality. While individual oxidative markers have been studied, the comprehensive impact of balance on mortality risks remains unclear, particularly among cancer survivors. We aimed to investigate associations Balance Score (OBS) with both general population This study included 37,317 adults (52% female) from National Health Nutrition Examination Survey (2001-2018). OBS was calculated based antioxidant pro-oxidant exposures categorized into quartiles. Survey-weighted Cox proportional hazards models were used estimate hazard ratios for risks. Restricted cubic spline analyses performed examine potential non-linear relationships. Stratified conducted further refine findings. During mean follow-up 9.1 years, 5,092 deaths occurred. Compared lowest quartile, highest quartile total associated lower all-cause (HR 0.68) 0.55). Among survivors, similar observed 0.66). Component analysis revealed consistent protective effects 0.60 mortality), while higher showed varying across causes. Higher risks, cancer-related mortality, effects, varied by
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1034 - 1034
Опубликована: Янв. 25, 2025
Postmortem interval (PMI) estimation is a challenge of utmost importance in forensic daily practice. Traditional methods face limitations accuracy and reliability, particularly for advanced decomposition stages. Recent advances “omics” sciences, providing holistic view postmortem biochemical changes, offer promising avenues overcoming these challenges. This systematic review aims at investigating the role mass-spectrometry-based approaches PMI to elucidate molecular mechanisms underlying predictable time-dependent alterations occurring after death. A search was performed, adhering PRISMA guidelines, through “free-text” protocols databases PubMed, SCOPUS Web Science. The inclusion criteria were as follows: experimental studies analyzing, investigated samples, animal or human corpses toto parts estimating MS-based untargeted omics approaches, with full texts English language. Quality assessment performed using STROBE ARRIVE critical appraisal checklists. total 1152 papers screened 26 included. Seventeen adopted proteomic approach (65.4%), nine focused on metabolomics (34.6%) two lipidomics (7.7%). Most (57.7%) short PMIs (<7 days), remaining explored medium (7–120 days) (30.77%) long (>120 (15.4%). Muscle tissue most frequently analyzed substrate (34.6% papers), followed by liver (19.2%), bones (15.4%), cardiac blood leaking fluids (11.5%), lung, kidney serum (7.7%), spleen, vitreous humor heart (3.8%). Predictable degradation patterns macromolecules different biological substrates have been discussed, special attention insights into changes.
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2025, Номер 14(2), С. 203 - 203
Опубликована: Фев. 10, 2025
The interplay between oxidative stress and adipogenesis is a critical factor in the development of obesity its associated metabolic disorders. Excessive reactive oxygen species (ROS) disrupt key transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) CCAAT/enhancer-binding protein alpha (C/EBPα), impairing lipid metabolism, promoting adipocyte dysfunction, exacerbating inflammation insulin resistance. Antioxidants, classified endogenous (e.g., glutathione, superoxide dismutase, catalase) exogenous polyphenols, flavonoids, vitamins C E), are pivotal mitigating these effects by restoring redox balance preserving functionality. Endogenous antioxidants neutralize ROS safeguard cellular structures; however, under heightened stress, defenses often insufficient, necessitating dietary supplementation. Exogenous derived from plant-based sources, polyphenols vitamins, act through direct scavenging, upregulation antioxidant enzymes, modulation signaling pathways like nuclear kappa B (NF-κB) PPARγ, reducing peroxidation, inflammation, dysfunction. Furthermore, they influence epigenetic regulation transcriptional networks to restore differentiation limit accumulation. Antioxidant-rich diets, including Mediterranean diet, strongly with improved health, reduced rates, enhanced sensitivity. Advances personalized therapies, guided biomarkers supported novel delivery systems, present promising avenues for optimizing therapeutic interventions. This review, "Crosstalk Between Antioxidants Adipogenesis: Mechanistic Pathways Their Role Metabolic Health", highlights mechanistic which regulate enhance health.
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2025, Номер 17(5), С. 719 - 719
Опубликована: Фев. 20, 2025
Tumors of the central nervous system (CNS), especially gliomas, pose a significant clinical challenge due to their aggressive nature and limited therapeutic options. Emerging research highlights critical role gut microbiota in regulating CNS health disease. The composition is essential for maintaining homeostasis, as it modulates immune responses, oxidative status, neuroinflammation. microbiota–gut–brain axis, bidirectional communication network, plays pivotal cancer disease treatment, exerting its influence through neural, endocrine, immunological, metabolic pathways. Recent studies suggest that influences solidification tumor microenvironment dysbiosis may promote glioma development by modulating systemic inflammation stress, which contributes tumorigenesis progression. This review interrogates impact on glioma, focusing pathways such NF-κB, MAPK, PI3K/Akt/mTOR, Kynurenine/AhR drive proliferation, evasion, therapy resistance. Furthermore, we explore emerging strategies, including probiotics microbiota-based interventions, show potential these enhancing immunotherapies checkpoint inhibitors. By multifaceted interactions between microbiota, tumors, this microbiota-targeted therapies manipulation complement enhance current treatments.
Язык: Английский
Процитировано
1
Reviews in Fish Biology and Fisheries, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2025, Номер 14(3), С. 264 - 264
Опубликована: Фев. 25, 2025
Autophagy is a fundamental cellular process that maintains homeostasis by degrading damaged components and regulating stress responses. It plays crucial role in cancer biology, including tumor progression, metastasis, therapeutic resistance. Oxidative stress, similarly, key to maintaining balance oxidants antioxidants, with its disruption leading molecular damage. The interplay between autophagy oxidative particularly significant, as reactive oxygen species (ROS) act both inducers by-products of autophagy. While can function suppressor early stages, it often shifts pro-tumorigenic advanced disease, aiding cell survival under adverse conditions such hypoxia nutrient deprivation. This dual mediated several signaling pathways, PI3K/AKT/mTOR, AMPK, HIF-1α, which coordinate the autophagic activity ROS production. In this review, we explore mechanisms interact across different hematological malignancies. We discuss how triggers autophagy, creating feedback loop promotes survival, dysregulation leads increased accumulation, exacerbating tumorigenesis. also examine implications targeting autophagy-oxidative axis cancer. Current strategies involve modulating through specific inhibitors, enhancing levels pro-oxidant compounds, combining these approaches conventional therapies overcome drug Understanding complex relationship provides critical insights into novel aimed at improving treatment outcomes.
Язык: Английский
Процитировано
1
BioEssays, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
Talin, a key integrin activator, is essential for cellular adhesion, signal transduction, and mechanical stability. Its transition between autoinhibited active conformations allows dynamic regulation of adhesion in response to environmental cues. Cholesterol-rich membrane microdomains, such as lipid rafts, organize stabilize signaling platforms, influencing talin conformational states. Cholesterol switch modulating activation, binding, adhesion. Environmental pollutants, including heavy metals air toxins, disrupt cholesterol homeostasis, destabilize interfere with talin-integrin interactions. These disruptions impair tissue repair, fidelity, contributing atherosclerosis cancer metastasis. Understanding talin's interaction cholesterol-rich domains offers critical insights into reveals the broader impact toxicants on function. This framework emphasizes importance composition, particularly cholesterol, mediating effects stressors suggests potential therapeutic interventions.
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2024, Номер 13(9), С. 1078 - 1078
Опубликована: Сен. 4, 2024
Cells constantly face the challenge of managing oxidants. In aerobic organisms, oxygen (O
Язык: Английский
Процитировано
7
Antioxidants, Год журнала: 2024, Номер 13(9), С. 1082 - 1082
Опубликована: Сен. 4, 2024
Repurposing saffron (
Язык: Английский
Процитировано
6