Physiological and Molecular Plant Pathology, Год журнала: 2025, Номер unknown, С. 102570 - 102570
Опубликована: Янв. 1, 2025
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(21), С. 3741 - 3741
Опубликована: Окт. 31, 2024
Conventional cancer treatments include surgical resection, chemotherapy, hyperthermia, immunotherapy, hormone therapy, and locally targeted therapies such as radiation therapy. Standard often require the use of multiple agents, which can activate nuclear factor kappa B (NF-κB) in tumor cells, leading to reduced cell death increased drug resistance. Moreover, agents also contributes added toxicity, resulting poor treatment outcomes. Cancer cells gradually develop resistance almost all chemotherapeutics through various mechanisms, efflux, alterations metabolism transport, changes signal transduction pathways, enhanced DNA repair capacity, evasion apoptosis, mutations, reactivation targets, interaction with microenvironment, cell-stroma interactions, epithelial–mesenchymal transition (EMT)-mediated chemoresistance, epigenetic modifications, metabolic alterations, effect stem (CSCs). Developing new strategies improve chemotherapy sensitivity while minimizing side effects is essential for achieving better therapeutic outcomes enhancing patients’ quality life. One promising approach involves combining conventional propolis its flavonoids. These natural compounds may enhance response reducing toxicity. Propolis components sensitize chemotherapeutic likely by inhibiting NF-κB activation, reprogramming tumor-associated macrophages (TAMs; an M2-like phenotype), thereby release matrix metalloproteinase (MMP)-9, cytokines, chemokines, vascular endothelial growth (VEGF). By TAMs, overcome EMT-mediated disrupt crosstalk between CSCs, inhibit maintenance stemness, reverse acquired immunosuppression, thus promoting antitumor mediated cytotoxic T-cells. This review highlights potential flavonoids modulate responsiveness modalities. The evidence suggests that novel incorporating could be developed positive cytotoxicity peripheral blood leukocytes, liver, kidney cells. Therefore, polyphenolic/flavonoid hold combination clinical types cancers.
Язык: Английский
Процитировано
6
ACS Omega, Год журнала: 2024, Номер 9(23), С. 25014 - 25026
Опубликована: Май 31, 2024
The utilization of metallodrugs as a viable alternative to organic molecules has gained significant attention in modern medicine. We hereby report synthesis new imine quinoline ligand (IQL)-based Cu(II) complexes and evaluation their potential biological applications. Syntheses the were achieved by condensation 7-chloro-2-hydroxyquinoline-3-carbaldehyde 2,2′-thiodianiline, followed complexation with metal ions. synthesized characterized using UV–vis spectroscopy, TGA/DTA, FTIR 1H 13C NMR pXRD. pXRD diffractogram analysis revealed that its polycrystalline systems, nanolevel average crystallite sizes 13.28, 31.47, 11.57 nm for IQL, CuL, CuL2, respectively. molar conductivity confirmed nonelectrolyte nature complexes. activity was evaluated vitro assays, examine anticancer against MCF-7 human breast cancer cell line antibacterial Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli Pseudomonas aeruginosa) bacterial strains. CuL complex had highest cytotoxic potency cells, an IC50 43.82 ± 2.351 μg/mL. At 100 μg/mL, induced largest reduction proliferation 97%, whereas IQL reduced 53% CuL2 28%. minimum inhibitory concentration found be 12.5 μg/mL three tested pathogens. Evaluation antioxidant 2,2-diphenyl-1-picrylhydrazyl exhibited 153.3 1.02 Molecular docking results showed strong binding affinities active sites S. aureus, E. coli, estrogen receptor alpha, indicating high compared CuL2.
Язык: Английский
Процитировано
5
Antioxidants, Год журнала: 2024, Номер 13(9), С. 1062 - 1062
Опубликована: Авг. 30, 2024
Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.
Язык: Английский
Процитировано
5
Antioxidants, Год журнала: 2024, Номер 13(12), С. 1508 - 1508
Опубликована: Дек. 10, 2024
Healthcare professionals frequently experience significant work overload, which often leads to substantial physical and psychological stress. This stress is closely linked increased oxidative a corresponding decline in energy levels. scoping review investigates the potential impact of dietary antioxidants food supplements conjunction with diet controlling these negative effects. Through an analysis biochemical pathways involved metabolism, paper emphasizes effectiveness targeted interventions. Key antioxidants, such as vitamins C E, polyphenols, carotenoids, are evaluated for their ability counteract enhance Additionally, assesses various supplements, including omega-3 fatty acids, coenzyme Q10, ginseng, mechanisms action enhancement. Practical guidelines incorporating energy-boost strategies into routine healthcare provided, emphasizing importance modifications reducing improving overall well-being performance high-stress environments. The concludes by suggesting directions future research validate findings explore new interventions that may further support under overload.
Язык: Английский
Процитировано
5
Physiological and Molecular Plant Pathology, Год журнала: 2025, Номер unknown, С. 102570 - 102570
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0