Neuroprotective Effects of Curcumin in Neurodegenerative Diseases

Foods, Год журнала: 2024, Номер 13(11), С. 1774 - 1774

Опубликована: Июнь 5, 2024

Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now considered candidate drug for treatment neurological diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), Huntington’s (HD), Multiple Sclerosis (MS), Amyotrophic Lateral (ALS), and prion disease, due to its potent anti-inflammatory, antioxidant potential, anticancerous, immunomodulatory, neuroprotective, antiproliferative, antibacterial activities. Traditionally, curcumin has been used medicinal dietary purposes in Asia, India, China. However, low water solubility, poor stability blood, high rate metabolism, limited bioavailability, little capability cross blood–brain barrier (BBB) have clinical application curcumin, despite important pharmacological activities this drug. A variety nanocarriers, liposomes, micelles, dendrimers, cubosome nanoparticles, polymer solid lipid nanoparticles developed with great success effectively deliver active brain cells. Functionalization on surface brain-specific ligands makes them target-specific, which should significantly improve bioavailability reduce harmful effects. The aim review summarize studies and/or containing most common neurodegenerative highlighting neuroprotective potential nutraceutical.

Язык: Английский

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Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 31, 2025

Despite the diverse applications of γ radiation in radiotherapy, industrial processes, and sterilization, it causes hazardous effects on living organisms, such as cellular senescence, persistent cell cycle arrest, mitochondrial dysfunction. This study evaluated efficacy curcumin nanoparticles (CNPs) mitigating dysfunction senescence induced by rat brain tissues. Four groups male Wistar albino rats (n = 8 per group) were included: (Gr1) control group; (Gr2) CNPs group (healthy receiving oral administration at a dose 10 mg/kg/day, three times week for eight weeks); (Gr3) irradiated (rats exposed to single Gy head irradiation); (Gr4) + (irradiated treated with CNPs). The data obtained demonstrated that weeks attenuated oxidative stress γ-irradiated lowering brain's lipid peroxidation level [malondialdehyde (MDA)] enhancing antioxidant markers [superoxide dismutase (SOD), reduced glutathione (GSH), total capacity (TAC)] (P < 0.05). In addition, significantly increased function improving complex I, II, ATP production levels compared group. rats, also showed anti-neuroinflammatory reducing interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), nuclear factor-kappa B (NF-ĸB) Moreover, administered β-galactosidase activity expression p53, p21, p16 genes 0.05) while concurrently inducing significant increase AMPK mRNA conclusion, ameliorated neurotoxicity hold promise novel agent delay via their combined antioxidant, anti-inflammatory, mitochondrial-enhancing properties.

Язык: Английский

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Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Pharmacological Research, Год журнала: 2025, Номер 213, С. 107641 - 107641

Опубликована: Фев. 1, 2025

Язык: Английский

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Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 114 - 114

Опубликована: Янв. 15, 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite promising therapeutic potential, poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers viable solution to these challenges by enabling development curcumin-based nanoparticles (CNPs) that enhance bioavailability efficacy. This review provides comprehensive overview recent advancements in design synthesis CNPs cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, inorganic nanoparticles, highlighting their role improving pharmacokinetic pharmacodynamic profiles. The mechanisms which exert effects, such as inducing apoptosis, inhibiting cell proliferation, modulating signaling pathways, are explored details. Furthermore, we examine preclinical studies have demonstrated efficacy treating different types tumors, breast, colorectal, pancreatic cancers. Finally, addresses current future perspectives translation CNPs, emphasizing need further research optimize targeted delivery outcomes. By synthesizing latest research, this underscores potential avenue advancing

Язык: Английский

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Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective

Life, Год журнала: 2025, Номер 15(1), С. 113 - 113

Опубликована: Янв. 16, 2025

The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has profoundly impacted global health, with pneumonia emerging as a major complication in severe cases. pathogenesis of is marked the overproduction reactive oxygen species (ROS) and an excessive inflammatory response, resulting oxidative stress significant tissue damage, particularly respiratory system. Antioxidants have garnered considerable attention for their potential role managing mitigating modulating immune responses. This review provides comprehensive overview literature on use antioxidants hospitalized patients mild-to-moderate COVID-19. Studies exploring antioxidants, including vitamins, trace elements, nitric oxide (NO), ozone (O3), glutathione (GSH), L-carnitine, melatonin, bromelain, N-acetylcysteine (NAC), numerous polyphenols, yielded promising outcomes. Through ROS-scavenging properties, these molecules support endothelial function, reduce thrombosis risk, may help mitigate effects cytokine storm, key contributor to morbidity mortality. Clinical evidence suggests that antioxidant supplementation improve patient outcomes decreasing inflammation, supporting cell potentially shortening recovery times. Furthermore, symptoms exerting direct antiviral inhibit infection process genomic replication SARS-CoV-2 host cells. Moreover, work synergistically standard treatments viral-induced damage. By integrating findings from real-world data our clinical experience, we gain more profound understanding pneumonia. Further research combining reviews analysis crucial validate efficacy establish evidence-based guidelines practice.

Язык: Английский

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Behavioral and Biochemical Insights into the Therapeutic Potential of Mitocurcumin in a Zebrafish–Pentylenetetrazole (PTZ) Epilepsy Model

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 382 - 382

Опубликована: Март 7, 2025

Background/Objectives: Epilepsy is a complex neurological disorder with strong link to oxidative stress, which contributes seizure susceptibility and neuronal damage. This study aims investigate the effects of curcumin (Cur), sodium valproate (VPA), mitocurcumin (MitoCur), mitochondria-targeted curcumin, on behavioral stress parameters in zebrafish model pentylenetetrazole (PTZ)-induced seizures. Methods: Adult were exposed two concentrations (0.25 0.5 µM for Cur MitoCur; 0.25 mM VPA). Behavioral assessments, including locomotion, spatial exploration, directional movement, conducted using EthoVision XT tracking software. Oxidative markers, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx), total antioxidant status (TAS), analyzed brain homogenates. Results: analyses indicated dose-dependent effects, higher doses generally reducing activity. MitoCur at enhanced defenses reduced damage, while exhibited pro-oxidant shift. VPA improved TAS without significantly altering MDA levels. Conclusions: These findings emphasize importance dose optimization antioxidant-based epilepsy treatments highlight potential as targeted therapeutic option.

Язык: Английский

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Curcumin Administration Routes in Breast Cancer Treatment

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11492 - 11492

Опубликована: Окт. 26, 2024

Breast cancer is a public health concern worldwide, characterized by increasing incidence and mortality rates, requiring novel effective therapeutic strategies. Curcumin bioactive compound extracted from turmeric with several pharmacological activities. multifaceted anticancer agent through mechanisms including the modulation of signaling pathways, inhibition cell proliferation, induction apoptosis, production reactive oxygen species. However, poor water solubility bioavailability curcumin create important barriers in its clinical application. This review elaborates on potential breast treatment, focusing efficacy different administration routes synergistic effects other agents. The intravenous curcumin-loaded nanoparticles significantly improves outcomes compared to oral routes. Innovative formulations, such as nano-emulsifying drug delivery systems, have shown promise enhancing bioavailability. While ensures higher direct action tumor cells, it more invasive expensive than administration. Advancing research treatment essential for improving quality life patients.

Язык: Английский

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Nanocurcumin in myocardial infarction therapy: emerging trends and future directions

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12

Опубликована: Янв. 8, 2025

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Curcumin has been observed to significantly reduce pathological processes associated with MI. Its clinical application limited due its low bioavailability, rapid degradation, poor solubility. Advancements in nanotechnology can be used enhance therapeutic potentials nano-formulation enhances solubility, stability, allowing more precise delivery ischemic cardiac tissue. nanoparticles have successfully infarct size, maintain heart function by modulating essential molecular pathways liposomal formulations provide sustained release higher tissue penetration improved pharmacokinetics enhanced efficacy. Preclinical studies revealed that nanocurcumin drastically lower oxidative stress indicators, inflammatory cytokines, damage. Micelles composed polymers demonstrated high biocompatibility targeting capabilities increased cardio-protective effects. Research trials are for comprehensive analysis efficacy curcumin-based nano-therapeutics cardiovascular condition lowering risk

Язык: Английский

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Ophthalmic In Situ Nanocomposite Gel for Delivery of a Hydrophobic Antioxidant

Gels, Год журнала: 2025, Номер 11(2), С. 105 - 105

Опубликована: Фев. 2, 2025

The topical administration of in situ hydrogels for ocular pathologies is a promising application strategy providing high effectiveness and patient compliance. Curcumin, natural polyphenol, possesses all the prerequisites successful therapy ophthalmic diseases, but unfortunately its physicochemical properties hurdle practical use. Applying composite thermoresponsive hydrogel formulation embedded with polymer nanoparticles potent to overcome identified drawbacks. In present work we prepared uniform spherical (296.4 ± 3.1 nm) efficiently loaded curcumin (EE% 82.5 2.3%) based on biocompatible biodegradable poly-(lactic-co-glycolic acid). They were thoroughly physicochemically characterized terms FTIR, SEM, TGA, DLS, vitro release following Fickian diffusion (45.62 2.37%), stability over 6 months. Their lack cytotoxicity was demonstrated HaCaT cell lines, potential antioxidant protection also outlined, starting from concentrations as low 0.1 µM reaching 41% at 5 µM. An (17% w/v poloxamer 407 0.1% Carbopol) suitable optimized respect gelation temperature (31.40 0.36 °C), gelling time (8.99 0.28 s) upon tears dilution, gel erosion (90.75 4.06%). Upon curcumin-loaded nanoparticle embedding, appropriate pseudoplastic behavior viscosity 35 °C (2129 24 Pa∙s), 6-fold increase permeation, prolonged h.

Язык: Английский

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Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment

Antioxidants, Год журнала: 2025, Номер 14(2), С. 199 - 199

Опубликована: Фев. 10, 2025

Aging is a general biological process inherent in all living organisms. It characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as highly effective mechanism for suppressing the progression of malignant neoplasms. However, recent increasing evidence suggests “double-edged” role cancer development. According to these data, not only tumor suppressor that leads cell cycle arrest neoplastic cells, but also promoter ensures chronic proinflammatory and immunosuppressive microenvironment. In this regard, our review, we discuss data on destructive senescent cells pathogenesis cancer. We identify first time correlations between modulation senescence-associated secretory phenotype antitumor effects naturally occurring molecules.

Язык: Английский

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