Curcumin: A Magical Small Molecule with a Large Role in Active-Intelligent Degradable Food Packaging DOI Open Access
Di Wang, Siyu Zhou, Nan Li

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3917 - 3917

Published: April 21, 2025

Curcumin exhibits antioxidant, antibacterial, antitumor, and anti-inflammatory biological properties. Its dual functionality as both a food additive pH-sensitive colorant has led to extensive applications in meat products other systems, thereby garnering significant research interest. In recent years, curcumin-loaded active-intelligent packaging films have emerged promising innovation due their multifunctional capabilities: not only do they prevent microbial contamination extend shelf life, but also enable real-time freshness monitoring through visual colorimetric responses. This paper first delineates the molecular structure fundamental mechanisms of curcumin. Subsequently, it systematically reviews strategies for curcumin incorporation (including encapsulation techniques composite formulations) advanced fabrication methodologies developing biodegradable films. Finally, current polymer-based smart systems are critically analyzed, with prospective directions proposed address existing technological limitations.

Language: Английский

Neuroprotective Effects of Curcumin in Neurodegenerative Diseases DOI Creative Commons
Giuseppe Genchi, Graziantonio Lauria, Alessia Catalano

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1774 - 1774

Published: June 5, 2024

Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now considered candidate drug for treatment neurological diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), Huntington’s (HD), Multiple Sclerosis (MS), Amyotrophic Lateral (ALS), and prion disease, due to its potent anti-inflammatory, antioxidant potential, anticancerous, immunomodulatory, neuroprotective, antiproliferative, antibacterial activities. Traditionally, curcumin has been used medicinal dietary purposes in Asia, India, China. However, low water solubility, poor stability blood, high rate metabolism, limited bioavailability, little capability cross blood–brain barrier (BBB) have clinical application curcumin, despite important pharmacological activities this drug. A variety nanocarriers, liposomes, micelles, dendrimers, cubosome nanoparticles, polymer solid lipid nanoparticles developed with great success effectively deliver active brain cells. Functionalization on surface brain-specific ligands makes them target-specific, which should significantly improve bioavailability reduce harmful effects. The aim review summarize studies and/or containing most common neurodegenerative highlighting neuroprotective potential nutraceutical.

Language: Английский

Citations

22
Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy DOI Creative Commons
Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 114 - 114

Published: Jan. 15, 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite promising therapeutic potential, poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers viable solution to these challenges by enabling development curcumin-based nanoparticles (CNPs) that enhance bioavailability efficacy. This review provides comprehensive overview recent advancements in design synthesis CNPs cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, inorganic nanoparticles, highlighting their role improving pharmacokinetic pharmacodynamic profiles. The mechanisms which exert effects, such as inducing apoptosis, inhibiting cell proliferation, modulating signaling pathways, are explored details. Furthermore, we examine preclinical studies have demonstrated efficacy treating different types tumors, breast, colorectal, pancreatic cancers. Finally, addresses current future perspectives translation CNPs, emphasizing need further research optimize targeted delivery outcomes. By synthesizing latest research, this underscores potential avenue advancing

Language: Английский

Citations

4
Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats DOI Creative Commons

Omnia A. Moselhy,

Nahed Abdel-Aziz, Azza M. El-Bahkery

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 31, 2025

Despite the diverse applications of γ radiation in radiotherapy, industrial processes, and sterilization, it causes hazardous effects on living organisms, such as cellular senescence, persistent cell cycle arrest, mitochondrial dysfunction. This study evaluated efficacy curcumin nanoparticles (CNPs) mitigating dysfunction senescence induced by rat brain tissues. Four groups male Wistar albino rats (n = 8 per group) were included: (Gr1) control group; (Gr2) CNPs group (healthy receiving oral administration at a dose 10 mg/kg/day, three times week for eight weeks); (Gr3) irradiated (rats exposed to single Gy head irradiation); (Gr4) + (irradiated treated with CNPs). The data obtained demonstrated that weeks attenuated oxidative stress γ-irradiated lowering brain's lipid peroxidation level [malondialdehyde (MDA)] enhancing antioxidant markers [superoxide dismutase (SOD), reduced glutathione (GSH), total capacity (TAC)] (P < 0.05). In addition, significantly increased function improving complex I, II, ATP production levels compared group. rats, also showed anti-neuroinflammatory reducing interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), nuclear factor-kappa B (NF-ĸB) Moreover, administered β-galactosidase activity expression p53, p21, p16 genes 0.05) while concurrently inducing significant increase AMPK mRNA conclusion, ameliorated neurotoxicity hold promise novel agent delay via their combined antioxidant, anti-inflammatory, mitochondrial-enhancing properties.

Language: Английский

Citations

2
Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Gofarana Wilar, Cecep Suhandi, Kohji Fukunaga

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107641 - 107641

Published: Feb. 1, 2025

Language: Английский

Citations

2
Nanocurcumin in myocardial infarction therapy: emerging trends and future directions DOI Creative Commons

Mei Lv,

Qing Sun,

YU Yi-lin

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Curcumin has been observed to significantly reduce pathological processes associated with MI. Its clinical application limited due its low bioavailability, rapid degradation, poor solubility. Advancements in nanotechnology can be used enhance therapeutic potentials nano-formulation enhances solubility, stability, allowing more precise delivery ischemic cardiac tissue. nanoparticles have successfully infarct size, maintain heart function by modulating essential molecular pathways liposomal formulations provide sustained release higher tissue penetration improved pharmacokinetics enhanced efficacy. Preclinical studies revealed that nanocurcumin drastically lower oxidative stress indicators, inflammatory cytokines, damage. Micelles composed polymers demonstrated high biocompatibility targeting capabilities increased cardio-protective effects. Research trials are for comprehensive analysis efficacy curcumin-based nano-therapeutics cardiovascular condition lowering risk

Language: Английский

Citations

1
Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective DOI Creative Commons
Stefano Sanduzzi Zamparelli, Alessandro Sanduzzi, Marialuisa Bocchino

et al.

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 113 - 113

Published: Jan. 16, 2025

The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has profoundly impacted global health, with pneumonia emerging as a major complication in severe cases. pathogenesis of is marked the overproduction reactive oxygen species (ROS) and an excessive inflammatory response, resulting oxidative stress significant tissue damage, particularly respiratory system. Antioxidants have garnered considerable attention for their potential role managing mitigating modulating immune responses. This review provides comprehensive overview literature on use antioxidants hospitalized patients mild-to-moderate COVID-19. Studies exploring antioxidants, including vitamins, trace elements, nitric oxide (NO), ozone (O3), glutathione (GSH), L-carnitine, melatonin, bromelain, N-acetylcysteine (NAC), numerous polyphenols, yielded promising outcomes. Through ROS-scavenging properties, these molecules support endothelial function, reduce thrombosis risk, may help mitigate effects cytokine storm, key contributor to morbidity mortality. Clinical evidence suggests that antioxidant supplementation improve patient outcomes decreasing inflammation, supporting cell potentially shortening recovery times. Furthermore, symptoms exerting direct antiviral inhibit infection process genomic replication SARS-CoV-2 host cells. Moreover, work synergistically standard treatments viral-induced damage. By integrating findings from real-world data our clinical experience, we gain more profound understanding pneumonia. Further research combining reviews analysis crucial validate efficacy establish evidence-based guidelines practice.

Language: Английский

Citations

1
Antioxidant Peptide-Based Nanocarriers for Delivering Wound Healing Agents DOI

Inseo Lee,

Woo Hyun Kwon,

Jooyoung Kim

et al.

Tissue Engineering and Regenerative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

Citations

1
Phytoconstituents as emerging therapeutics for breast cancer: Mechanistic insights and clinical implications DOI Creative Commons

Mahalakshmi Devaraji,

Punniyakoti T. Veeraveedu

Cancer Pathogenesis and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Behavioral and Biochemical Insights into the Therapeutic Potential of Mitocurcumin in a Zebrafish–Pentylenetetrazole (PTZ) Epilepsy Model DOI Creative Commons

Alin Dumitru Ciubotaru,

Carmen-Ecaterina Leferman, Bogdan Ignat

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 382 - 382

Published: March 7, 2025

Background/Objectives: Epilepsy is a complex neurological disorder with strong link to oxidative stress, which contributes seizure susceptibility and neuronal damage. This study aims investigate the effects of curcumin (Cur), sodium valproate (VPA), mitocurcumin (MitoCur), mitochondria-targeted curcumin, on behavioral stress parameters in zebrafish model pentylenetetrazole (PTZ)-induced seizures. Methods: Adult were exposed two concentrations (0.25 0.5 µM for Cur MitoCur; 0.25 mM VPA). Behavioral assessments, including locomotion, spatial exploration, directional movement, conducted using EthoVision XT tracking software. Oxidative markers, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx), total antioxidant status (TAS), analyzed brain homogenates. Results: analyses indicated dose-dependent effects, higher doses generally reducing activity. MitoCur at enhanced defenses reduced damage, while exhibited pro-oxidant shift. VPA improved TAS without significantly altering MDA levels. Conclusions: These findings emphasize importance dose optimization antioxidant-based epilepsy treatments highlight potential as targeted therapeutic option.

Language: Английский

Citations

1
Curcumin Administration Routes in Breast Cancer Treatment DOI Open Access

B. C. Mayo,

Silvana Penroz,

Keila Torres

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11492 - 11492

Published: Oct. 26, 2024

Breast cancer is a public health concern worldwide, characterized by increasing incidence and mortality rates, requiring novel effective therapeutic strategies. Curcumin bioactive compound extracted from turmeric with several pharmacological activities. multifaceted anticancer agent through mechanisms including the modulation of signaling pathways, inhibition cell proliferation, induction apoptosis, production reactive oxygen species. However, poor water solubility bioavailability curcumin create important barriers in its clinical application. This review elaborates on potential breast treatment, focusing efficacy different administration routes synergistic effects other agents. The intravenous curcumin-loaded nanoparticles significantly improves outcomes compared to oral routes. Innovative formulations, such as nano-emulsifying drug delivery systems, have shown promise enhancing bioavailability. While ensures higher direct action tumor cells, it more invasive expensive than administration. Advancing research treatment essential for improving quality life patients.

Language: Английский

Citations

7