The role of graphene quantum dots in cutting‐edge medical therapies

Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(9)

Опубликована: Сен. 1, 2024

Abstract Graphene quantum dots (GQDs), owing to their unique optical, electrical, and chemical properties, have emerged as promising nanomaterials for various biomedical applications. This review provides a comprehensive overview of the latest advancements in utilization GQDs tissue engineering, wound healing, drug delivery systems, other therapies. The inherent properties GQDs, including high biocompatibility, tunable photoluminescence, significant surface area, make them ideal candidates enhancing medical treatments diagnostics. In improve mechanical biological performance scaffolds, promoting cell proliferation differentiation. For enhance antimicrobial activity facilitate faster regeneration. Their potential DDS is highlighted by ability deliver therapeutic agents efficiently, ensuring targeted controlled release. Additionally, play crucial role therapies, particularly cancer treatment, efficacy reducing side effects. While offer diagnostics, challenges such understanding long‐term cytotoxicity at higher concentrations, need standardized synthesis methods remain critical areas further research. also discusses future directions opportunities emphasizing transformative advancing modern healthcare solutions. insights presented here contribute expanding field GQD research, highlighting significantly patient outcomes drive innovations.

Язык: Английский

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Therapeutic Potential of Combined 5% Lifitegrast and Tocopherol Eye Drops in Managing Inflammation and Oxidative Stress in Murine Dry Eye

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 38 - 38

Опубликована: Янв. 1, 2025

Background/Objectives: This study aimed to evaluate the therapeutic effects of combined 5% lifitegrast (LF) and tocopherol (TCP) eye drops in a murine experimental dry (EDE) model. Methods: Female C57BL/6 were divided into seven groups: untreated controls, EDE control, + 0.05% cyclosporin A (CsA), (TCP), LF, LF TCP (once daily), (twice daily). Clinical parameters (tear volume, tear break-up time (TBUT), corneal fluorescein staining score (CFSS), film lipid layer grade (TFLLG)) assessed on days 7 14. Goblet cell density conjunctiva, CD4+ IFN-γ+ T cells, interleukin levels, reactive oxygen species (ROS) apoptotic cells analyzed day Results: Monotherapy with CsA showed improvements all clinical compared control (p < 0.05). Combination therapy groups demonstrated superior CsA, groups. percentages ROS levels cornea conjunctiva markedly reduced combination 0.01). Furthermore, significantly decreased Conclusions: Combined improved inflammatory oxidative stress markers. The can mitigate ocular surface damage by managing inflammation eye.

Язык: Английский

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SIRT3 mitigates dry eye disease through the activation of autophagy by deacetylation of FOXO1.

Experimental Eye Research, Год журнала: 2025, Номер unknown, С. 110328 - 110328

Опубликована: Март 1, 2025

Язык: Английский

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Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway

Investigative Ophthalmology & Visual Science, Год журнала: 2025, Номер 66(3), С. 44 - 44

Опубликована: Март 20, 2025

Purpose: This study aims to explore the therapeutic efficacy of evodiamine (EVO) in treatment dry eye disease (DED). Methods: Mouse models DED was developed using benzalkonium chloride drops and subcutaneous atropine injections. Corneal epithelial defects were assessed by fluorescein sodium staining, tear secretion measured with phenol red thread test. For vitro model, human corneal cells cultured a chloride–enriched medium. Phenotypic mechanistic analyses conducted real-time quantitative PCR, Western blotting, flow cytometry, immunofluorescence staining. Results: The administration EVO significantly enhanced mice, ameliorated ocular surface damage, decreased expression inflammatory factors, increased density conjunctival goblet cells. Furthermore, reduced oxidative stress promoting autophagy. Mechanistically, EVO-induced autophagy mediated via p53/mammalian target rapamycin pathway. Conclusions: These findings suggest that is potential agent for DED, its beneficial effects attributed activation through

Язык: Английский

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Nanozymes for Treating Ocular Diseases

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 13, 2024

Nanozymes, characterized by their nanoscale size and enzyme-like catalytic activities, exhibit diverse therapeutic potentials, including anti-oxidative, anti-inflammatory, anti-microbial, anti-angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery. Nanozymes show significant promise tackling multi-factored diseases, those influenced oxidation inflammation, like dry eye disease, age-related macular degeneration. Their small size, coupled with ease of modification integration into soft materials, facilitates effective penetration barriers, thereby enabling targeted or prolonged therapy within eye. This review is dedicated to exploring diseases that are intricately linked shedding light on role nanozymes managing these conditions. Additionally, recent studies elucidating advanced applications therapeutics, along materials disease management, discussed. Finally, this outlines directions future investigations aimed at bridging gap between nanozyme research clinical applications.

Язык: Английский

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A Modified Polydopamine Nanoparticle Loaded with Melatonin for Synergistic ROS Scavenging and Anti‐Inflammatory Effects in the Treatment of Dry Eye Disease

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), critical factor perpetuating inflammatory cycle in DED. Effectively scavenging ROS essential to impede progression In this study, boronophenylalanine‐ containing polydopamine (PDA‐PBA) nanoparticles are developed loaded with melatonin (MT), which blended poly(vinyl alcohol) (PVA) create drops PVA/ PDA‐PBA@MT (PPP@MT). vitro vivo studies demonstrate PPP@MT exhibits dual functionalities reducing production downregulating pathways, thereby preserving mitochondrial integrity further inhibiting programmed cell death. Following treatment, tear secretion, corneal structure, number goblet cells markedly restored mouse model dry eye, indicating therapeutic efficacy agent. Collectively, PPP@MT, characterized minimal side effects favorable bioavailability, offers promising insights for management DED other ROS‐mediated disorders.

Язык: Английский

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Dendrobium nobile : A Potential Therapeutic Approach for Dry Eye Disease

CABI eBooks, Год журнала: 2025, Номер unknown, С. 237 - 254

Опубликована: Март 24, 2025

Язык: Английский

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Associations between air pollution and daily outpatient visits for dry eye disease and the effect modification of temperature

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Март 27, 2025

Abstract Background Dry eye disease (DED) is one of the most common ocular surface disorders caused by various contributors. Air pollutants are considered a risk factor for diseases. We aimed to investigate associations between air (PM 2.5 , PM 10 NO 2 SO CO and O 3 ) constituents daily outpatient visits DED, as well modifying effect temperature on associations. Methods Daily data DED environmental variables during 2014–2019 were collected in Hangzhou, China. Distributed lag nonlinear models (DLNM) combined with time-stratified case-crossover design utilized evaluate effects 0‒3 days. Furthermore, we also estimated modification stratified median. The attributable fraction (AF) quantified. Stratified analyses gender, age, seasons conducted assess vulnerable population characteristics high-risk periods. Results Every interquartile range increase concentration significantly associated cases. AF 6.42% (95% CI: 1.09%, 11.58%), 8.00% (2.60%, 13.60%), 18.65% (11.52%, 25.21%), 10.82% (3.92%, 17.24%) 12.28% (0.23%, 22.86%), respectively. For constituents, − NH 4 + 4.34% (0.21%, 8.11%) 4.84% (0.18%, 9.09%), pollution significant low-temperature level CO; while statistically insignificant high-temperature level. Subgroup indicated present winter among patients aged 21–40 but other age groups. Conclusion Our results revealed that visits. Low temperatures might hazardous pollution. Besides, individuals pollution, was period. Clinical trial number Not applicable. Graphical abstract

Язык: Английский

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Streptococcus thermophilus iHA318 Improves Dry Eye Symptoms by Mitigating Ocular Surface Damage in a Mouse Model

Microorganisms, Год журнала: 2024, Номер 12(7), С. 1306 - 1306

Опубликована: Июнь 27, 2024

Dry eye is a complicated ocular surface disease that causes discomfort, visual disturbance, and frequently observed damage. Emerging hypotheses suggest probiotics may help relieve dry symptoms by modulating inflammation oxidative stress. This study aimed to investigate the therapeutic effects of

Язык: Английский

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Oxygen, the Paradox of Life and the Eye

Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(9)

Опубликована: Сен. 13, 2024

Oxidative stress, caused by the formation of free radicals, such as reactive oxygen species (ROS), leads to cell and tissue degradation, contributing various diseases aging. While is essential for aerobic organisms, it inevitably causes oxidative stress. Antioxidants protect against damage from stress arises when an imbalance occurs between radical production antioxidant defenses. However, investigating whether excess antioxidants, almost eliminating could benefit aging disease susceptibility, was observed that a basic level appears necessary maintain correct homeostasis tissues organs life in general. Therefore, this review aimed compile most significant recent papers characterizing describing dual role molecule precursor which can be detrimental life. We conducted targeted searches PubMed Google browsers gather all relevant papers. then focused on eye, organ particularly vulnerable due its high metabolic activity combined with direct exposure light environmental pollutants, produces substantial number radicals (mainly ROS). present curated selection literature main ocular pathologies posterior anterior segments highlighting factor. Additionally, we report how endogenous exogenous antioxidants mitigate development progression these diseases. Finally, consider frequently overlooked aspect: balance oxidants maintaining homeostatic equilibrium organs. It widely recognized overwhelm occurs, leading negative consequences organism's homeostasis. emphasize similarly dangerous situation arise presence overwhelms drastically reducing their amount adversely affecting longevity. Unfortunately, no specific studies have addressed particular eye.

Язык: Английский

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