Anti- and pro-oxidant properties of polyphenols and their role in modulating glutathione synthesis, activity and cellular redox potential: Potential synergies for disease management

Advances in Redox Research, Год журнала: 2024, Номер 11, С. 100099 - 100099

Опубликована: Апрель 9, 2024

Cellular metabolic activities are controlled by pathways catalyzed enzymes, closely regulated signal transduction through induction or inhibition processes. Metabolic disorders and cellular dysregulation often linked to redox-dependent signaling in a complex relationship. Glutathione (GSH) polyphenols which known regulators of redox homeostasis have been studied immensely. However, no study has considered their potential interactions synergies as novel mechanisms control disorders. GSH does not only act an antioxidant, but ligand that binds inactivate enzymes toxins. Also, depending on environment, structure, pH, concentration availability transition metals high charge density, may possess either anti-oxidant pro-oxidant properties. Owing remarkable influence individual compounds, this the between disease management. Generally, both reduce oxidative stress normal cells under exacerbating conditions low GSH/GSSG ratio, induce apoptotic abnormal cells. Investigating effects polyphenol concentrations, metals, caloric restriction structure apoptosis proliferation cancer future be basis for synergistic exploitation

Язык: Английский

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Polyphenols in Ruminant Nutrition and Their Effects on Reproduction

Antioxidants, Год журнала: 2022, Номер 11(5), С. 970 - 970

Опубликована: Май 14, 2022

The feeding of domestic animals with diets in which polyphenols are present is increasingly attracting the attention nutritionists and scientists. This review summarizes knowledge regarding polyphenols’ possible positive negative effects their bioavailability. bioavailability substances a prerequisite for any postabsorption effect vivo. Positive properties have been confirmed previous studies on rich polyphenols, such as secondary metabolites plants. Free radicals formed every organism, leading to oxidative stress. highly reactive molecules can react cells macromolecules cause damage, including reproductive cells. Some at specific concentrations antioxidant that positively affect animal reproduction by improving quality male female gametes. intake phytoestrogens mimic estrogen function induce various pathological conditions tract, ovarian, fallopian, uterine dysfunction. metabolism genistein daidzein yields equol p-phenyl-phenol, decline cow fertilization. findings so far confirm numerous questions still need be answered. points out importance using both benificial some unfavorable diets.

Язык: Английский

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Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12155 - 12155

Опубликована: Ноя. 12, 2024

The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease. Several bioactive nutrients, including medicinal herbs, flavonoids, bioavailable polyphenol-combined nanoparticles, as well probiotics, vitamin D omega-3 fatty acids, have been shown improve blood-brain barrier (BBB) dysfunction, endogenous neurosteroid homeostasis brain function. These can inhibit oxidative neuroinflammation, which are linked the pathogenesis of various neurological disorders. Interestingly, flavonoids exhibit dose-dependent effects, activating nuclear factor erythroid 2-related 2 (Nrf2) pathway at physiological/low dose (neurohormesis). This leads upregulation antioxidant phase II genes proteins such heme oxygenase-1 (HO-1) sirtuin-1 (Sirt1), activated by curcumin resveratrol, respectively. adaptive neuronal response mechanisms help protect against reactive oxygen species (ROS) neurotoxicity. Impaired Nrf2 hormone signaling exacerbate selective vulnerability neuroinflammatory conditions, contributing onset progression neurodegenerative psychiatric disorders, Alzheimer's disease, anxiety depression other due neurons stress. review focuses on targeting redox regulate BBB damage associated with altered GABAergic neurotransmission. By exploring underlying molecular using innovative technologies, we aim develop promising neuroprotective strategies personalized nutritional neuroregenerative therapies prevent or attenuate ultimately promoting health.

Язык: Английский

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Effects of dietary addition of mulberry leaf powder on blood metabolites and fecal microbiota composition in Hu sheep

Frontiers in Animal Science, Год журнала: 2025, Номер 5

Опубликована: Янв. 3, 2025

In livestock production, ruminant feed resources are often scarce, and numerous challenges arise during such as immune disorders oxidative stress. Mulberry leaves rich in various nutrients exhibit significant antioxidant immune-regulating properties. Therefore, they can be used an unconventional resource production. This study investigated the effects of mulberry (ML) a supplement on blood biochemical parameters hindgut microbial structure Hu sheep. Sixteen sheep were randomly divided into two groups fed either 0 or 60 g/d ML. Compared to control group, ML showed increase AKP ( P = 0.027) GPT 0.002) levels blood, while TP 0.001) decreased significantly. Additionally, there was increasing trend GSH-Px 0.082) CAT 0.058) levels. After addition ML, abundance Campylobacterota, Campylobacter , Mailhella significantly increased < 0.05), Alloprevotella Roseburia Prevotellaceae UCG-003 0.05). serve natural regulate status animals, thereby promoting healthy production ruminants.

Язык: Английский

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Exogenous application of melatonin to plants, algae, and harvested products to sustain agricultural productivity and enhance nutritional and nutraceutical value: A meta-analysis

Environmental Research, Год журнала: 2021, Номер 200, С. 111746 - 111746

Опубликована: Июль 22, 2021

Язык: Английский

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Application of polyphenolic compounds in animal nutrition and their promising effects

Journal of Animal and Feed Sciences, Год журнала: 2023, Номер 32(3), С. 233 - 256

Опубликована: Март 20, 2023

1. Abd El Tawab A.M., Kholif A.E., Khattab M.S.A., Shaaban M.M., Hadhoud F.I., Mostafa M.M.M., Olafadehan O.A., 2020. Feed utilization and lactational performance of Barki sheep fed diets containing thyme or celery. Small Rumin. Res. 192, 106249, https://doi.org/10.1016/j.smal... CrossRef Google Scholar

Язык: Английский

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Improving Reproductive Performance and Health of Mammals Using Honeybee Products

Antioxidants, Год журнала: 2021, Номер 10(3), С. 336 - 336

Опубликована: Фев. 24, 2021

Honeybee products have positive effects on the reproductive performance of mammals. Many honeybee product constituents are biologically active, with antioxidant, antimicrobial, antiviral, anti-inflammatory, immunomodulatory, antifungal, wound-healing, and cardio-protective properties. also improve male female fertility rates by enhancing gamete cryopreservation, in vitro maturation fertilization, embryo development. Previously published studies confirmed their efficacy for alleviating toxicity caused contaminants lifestyle habits that impair overall health well-being. However, high-dose oral administration may adversely affect system, unfavorable were alleviated treatment cessation. For this reason, review proposes bioactive components from bee can be used as a strategy improving

Язык: Английский

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Effects of a Nanoencapsulated Moringa Leaf Ethanolic Extract on the Physiology, Metabolism and Reproductive Performance of Rabbit Does during Summer

Antioxidants, Год журнала: 2021, Номер 10(8), С. 1326 - 1326

Опубликована: Авг. 23, 2021

This study investigated the effect of Moringa leaf ethanolic extract (MLEE) on heat-tolerance variables and reproductive performance rabbit does bred under hot climate conditions. Additionally, nanoencapsulation technology biological efficiency MLEE was considered. A total 56 were randomly divided into four experimental groups treated with 50 mg/kg body weight (BW) nonencapsulated MLEE, 25 or 10 BW nanoencapsulated not (Control, C). The treatments continued for days, including mating pregnancy times. Physiological hematochemical variables, hormonal profiles, (kindling rate litter characteristics) determined. active components identified. results indicated that has 30 components. All MLEE-based reduced heat-stress-related indicators, such as rectal temperatures, respiratory rates heart rate; improved attributes, redox status, hormones (progesterone prolactin); increased size, kindling rate, size at birth birth. Adding can alleviate negative impacts heat stress by improving metabolism, balance during pregnancy. These effects seen whether MLLE in free encapsulated forms. However, use allowed 80% reduction (10 BW) optimal dose (50 without affecting treatment. support importance bioavailability when they are orally administered.

Язык: Английский

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Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

Nutrients, Год журнала: 2024, Номер 16(12), С. 1815 - 1815

Опубликована: Июнь 9, 2024

Androgen production primarily occurs in Leydig cells located the interstitial compartment of testis. In aging males, testosterone is crucial for maintaining muscle mass and strength, bone density, sexual function, metabolic health, energy levels, cognitive as well overall well-being. As men age, by testes begins to decline at a rate approximately 1% per year starting from their 30s. This review highlights recent findings concerning use natural polyphenolics compounds, such flavonoids, resveratrol, phenolic acids, enhance production, thereby preventing age-related degenerative conditions associated with insufficiency. Interestingly, most polyphenolic antioxidants having beneficial effects on tend expression steroidogenic acute regulatory protein (Star) gene cells. The STAR facilitates entry steroid precursor cholesterol inside mitochondria, rate-limiting step androgen biosynthesis. Natural compounds can also improve activities enzymes, hypothalamus-pituitary gland axis signaling, bioavailability. Thus, many luteolin, quercetin, ferulic acid phenethyl ester or gigantol may be promising delaying initiation late-onset hypogonadism accompanying males.

Язык: Английский

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Polyphenols as a strategy for improving male reproductive system

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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