Anti- and pro-oxidant properties of polyphenols and their role in modulating glutathione synthesis, activity and cellular redox potential: Potential synergies for disease management

Advances in Redox Research, Journal Year: 2024, Volume and Issue: 11, P. 100099 - 100099

Published: April 9, 2024

Cellular metabolic activities are controlled by pathways catalyzed enzymes, closely regulated signal transduction through induction or inhibition processes. Metabolic disorders and cellular dysregulation often linked to redox-dependent signaling in a complex relationship. Glutathione (GSH) polyphenols which known regulators of redox homeostasis have been studied immensely. However, no study has considered their potential interactions synergies as novel mechanisms control disorders. GSH does not only act an antioxidant, but ligand that binds inactivate enzymes toxins. Also, depending on environment, structure, pH, concentration availability transition metals high charge density, may possess either anti-oxidant pro-oxidant properties. Owing remarkable influence individual compounds, this the between disease management. Generally, both reduce oxidative stress normal cells under exacerbating conditions low GSH/GSSG ratio, induce apoptotic abnormal cells. Investigating effects polyphenol concentrations, metals, caloric restriction structure apoptosis proliferation cancer future be basis for synergistic exploitation

Language: Английский

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Polyphenols in Ruminant Nutrition and Their Effects on Reproduction

Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 970 - 970

Published: May 14, 2022

The feeding of domestic animals with diets in which polyphenols are present is increasingly attracting the attention nutritionists and scientists. This review summarizes knowledge regarding polyphenols’ possible positive negative effects their bioavailability. bioavailability substances a prerequisite for any postabsorption effect vivo. Positive properties have been confirmed previous studies on rich polyphenols, such as secondary metabolites plants. Free radicals formed every organism, leading to oxidative stress. highly reactive molecules can react cells macromolecules cause damage, including reproductive cells. Some at specific concentrations antioxidant that positively affect animal reproduction by improving quality male female gametes. intake phytoestrogens mimic estrogen function induce various pathological conditions tract, ovarian, fallopian, uterine dysfunction. metabolism genistein daidzein yields equol p-phenyl-phenol, decline cow fertilization. findings so far confirm numerous questions still need be answered. points out importance using both benificial some unfavorable diets.

Language: Английский

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Effects of dietary addition of mulberry leaf powder on blood metabolites and fecal microbiota composition in Hu sheep

Frontiers in Animal Science, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 3, 2025

In livestock production, ruminant feed resources are often scarce, and numerous challenges arise during such as immune disorders oxidative stress. Mulberry leaves rich in various nutrients exhibit significant antioxidant immune-regulating properties. Therefore, they can be used an unconventional resource production. This study investigated the effects of mulberry (ML) a supplement on blood biochemical parameters hindgut microbial structure Hu sheep. Sixteen sheep were randomly divided into two groups fed either 0 or 60 g/d ML. Compared to control group, ML showed increase AKP ( P = 0.027) GPT 0.002) levels blood, while TP 0.001) decreased significantly. Additionally, there was increasing trend GSH-Px 0.082) CAT 0.058) levels. After addition ML, abundance Campylobacterota, Campylobacter , Mailhella significantly increased < 0.05), Alloprevotella Roseburia Prevotellaceae UCG-003 0.05). serve natural regulate status animals, thereby promoting healthy production ruminants.

Language: Английский

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Exogenous application of melatonin to plants, algae, and harvested products to sustain agricultural productivity and enhance nutritional and nutraceutical value: A meta-analysis

Environmental Research, Journal Year: 2021, Volume and Issue: 200, P. 111746 - 111746

Published: July 22, 2021

Language: Английский

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Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12155 - 12155

Published: Nov. 12, 2024

The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease. Several bioactive nutrients, including medicinal herbs, flavonoids, bioavailable polyphenol-combined nanoparticles, as well probiotics, vitamin D omega-3 fatty acids, have been shown improve blood-brain barrier (BBB) dysfunction, endogenous neurosteroid homeostasis brain function. These can inhibit oxidative neuroinflammation, which are linked the pathogenesis of various neurological disorders. Interestingly, flavonoids exhibit dose-dependent effects, activating nuclear factor erythroid 2-related 2 (Nrf2) pathway at physiological/low dose (neurohormesis). This leads upregulation antioxidant phase II genes proteins such heme oxygenase-1 (HO-1) sirtuin-1 (Sirt1), activated by curcumin resveratrol, respectively. adaptive neuronal response mechanisms help protect against reactive oxygen species (ROS) neurotoxicity. Impaired Nrf2 hormone signaling exacerbate selective vulnerability neuroinflammatory conditions, contributing onset progression neurodegenerative psychiatric disorders, Alzheimer's disease, anxiety depression other due neurons stress. review focuses on targeting redox regulate BBB damage associated with altered GABAergic neurotransmission. By exploring underlying molecular using innovative technologies, we aim develop promising neuroprotective strategies personalized nutritional neuroregenerative therapies prevent or attenuate ultimately promoting health.

Language: Английский

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Improving Reproductive Performance and Health of Mammals Using Honeybee Products

Antioxidants, Journal Year: 2021, Volume and Issue: 10(3), P. 336 - 336

Published: Feb. 24, 2021

Honeybee products have positive effects on the reproductive performance of mammals. Many honeybee product constituents are biologically active, with antioxidant, antimicrobial, antiviral, anti-inflammatory, immunomodulatory, antifungal, wound-healing, and cardio-protective properties. also improve male female fertility rates by enhancing gamete cryopreservation, in vitro maturation fertilization, embryo development. Previously published studies confirmed their efficacy for alleviating toxicity caused contaminants lifestyle habits that impair overall health well-being. However, high-dose oral administration may adversely affect system, unfavorable were alleviated treatment cessation. For this reason, review proposes bioactive components from bee can be used as a strategy improving

Language: Английский

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Application of polyphenolic compounds in animal nutrition and their promising effects

Journal of Animal and Feed Sciences, Journal Year: 2023, Volume and Issue: 32(3), P. 233 - 256

Published: March 20, 2023

1. Abd El Tawab A.M., Kholif A.E., Khattab M.S.A., Shaaban M.M., Hadhoud F.I., Mostafa M.M.M., Olafadehan O.A., 2020. Feed utilization and lactational performance of Barki sheep fed diets containing thyme or celery. Small Rumin. Res. 192, 106249, https://doi.org/10.1016/j.smal... CrossRef Google Scholar

Language: Английский

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Polyphenols as a strategy for improving male reproductive system

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 17, 2025

Language: Английский

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Effects of phenolic compounds on broiler’s diet: a systematic review

World s Poultry Science Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 5, 2025

Language: Английский

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Phytoestrogens Modulate Bovine G Protein‐Coupled Receptors and Play a Critical Role in Regulating Reproductive Functions in Animals

Reproduction in Domestic Animals, Journal Year: 2025, Volume and Issue: 60(3)

Published: March 1, 2025

Phytoestrogens are secondary plant metabolites that structurally analogous to endogenous oestrogens and bind Bovine G Protein-Coupled Receptors (GPCRs) in animals. Their interaction with GPCRs activates intracellular signalling cascades, such as the cAMP/PKA pathway, which plays a crucial role ovarian follicle development luteinisation. These interactions may enhance reproductive performance by improving fertility, synchronising estrous cycles, promoting ovulation. also influence regularity timing of cycle, offering potential applications synchronisation management. In this study, molecular docking was conducted on 12,000 phytochemicals identify GPCR ligands. From extensive screening, five compounds highest binding affinities were selected. Notably, Genistein Apigenin emerged top candidates, scores (-8.58 kcal/mol -8.27 kcal/mol) lower RMSD values (0.69 1.30) compared synthetic agonists Estradiol (-6.07 1.02), respectively. Molecular dynamics simulations (MDS) confirmed stability these phytoestrogen -GPCR complexes, suggesting effective sustained interactions. The screened phytoestrogens demonstrated favourable pharmacokinetic profiles, including non-toxicity, non-carcinogenicity, high gastrointestinal absorption, positioning them viable candidates for enhancing dairy cattle through modulation. findings suggest could be used feed additives improve outcomes, novel approach modulate pathways

Language: Английский

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