Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 176, С. 113869 - 113869

Опубликована: Июль 16, 2021

Язык: Английский

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Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis

Biomolecules, Год журнала: 2021, Номер 11(8), С. 1095 - 1095

Опубликована: Июль 23, 2021

Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in pathophysiological processes. mediate wound contractions, but their persistent presence tissues is central to driving fibrosis, making them attractive cell targets for the development of therapeutic treatments. However, due shared cellular markers several other phenotypes, specific targeting myofibroblasts has long presented a scientific and clinical challenge. In recent years, have drawn much attention among research communities from disciplines specialisations. As further uncovers characterisations myofibroblast formation, function, regulation, realisation novel interventional routes within pathologies emerged. The community approaching means finally target these cells, prevent accelerate scarless healing, attenuate associated disease-processes settings. This comprehensive review article describes phenotype, origins, diverse physiological pathological functionality. Special been given mechanisms molecular pathways governing differentiation, updates interventions.

Язык: Английский

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Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease

Journal of Hepatology, Год журнала: 2022, Номер 78(1), С. 191 - 206

Опубликована: Сен. 5, 2022

Язык: Английский

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Oxidative Stress in Liver Pathophysiology and Disease

Antioxidants, Год журнала: 2023, Номер 12(9), С. 1653 - 1653

Опубликована: Авг. 22, 2023

The liver is an organ that particularly exposed to reactive oxygen species (ROS), which not only arise during metabolic functions but also the biotransformation of xenobiotics. disruption redox balance causes oxidative stress, affects function, modulates inflammatory pathways and contributes disease. Thus, stress implicated in acute injury pathogenesis prevalent infectious or chronic diseases such as viral hepatitis B C, alcoholic fatty disease, non-alcoholic disease (NAFLD) steatohepatitis (NASH). Moreover, plays a crucial role progression fibrosis, cirrhosis hepatocellular carcinoma (HCC). Herein, we provide overview on effects pathophysiology mechanisms by promotes

Язык: Английский

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Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease

Antioxidants, Год журнала: 2021, Номер 11(1), С. 91 - 91

Опубликована: Дек. 30, 2021

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress induce progression of to NASH stimulating Kupffer cells, hepatic stellate hepatocytes. Therefore, are underway identify role antioxidants in treatment NAFLD. In this review, we have summarized origins reactive oxygen species (ROS) relationship between ROS NAFLD, discussed use as therapeutic agents for

Язык: Английский

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Fructose and the Liver

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(13), С. 6969 - 6969

Опубликована: Июнь 28, 2021

Chronic diseases represent a major challenge in world health. Metabolic syndrome is constellation of disturbances affecting several organs, and it has been proposed to be liver-centered condition. Fructose overconsumption may result insulin resistance, oxidative stress, inflammation, elevated uric acid levels, increased blood pressure, triglyceride concentrations both the liver. Non-alcoholic fatty liver disease (NAFLD) term widely used describe excessive infiltration absence alcohol, autoimmune disorders, or viral hepatitis; attributed obesity, high sugar fat consumption, sedentarism. If untreated, NAFLD can progress nonalcoholic steatohepatitis (NASH), characterized by inflammation mild fibrosis addition and, eventually, advanced scar tissue deposition, cirrhosis, finally cancer, which constitutes culmination disease. Notably, fructose recognized as mediator NAFLD, significant correlation between intake degree found preclinical clinical studies. Moreover, risk factor for cancer development. Interestingly, induces number proinflammatory, fibrogenic, oncogenic signaling pathways that explain its deleterious effects body, especially

Язык: Английский

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Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

Marine Drugs, Год журнала: 2021, Номер 19(10), С. 531 - 531

Опубликована: Сен. 23, 2021

Acute inflammation is a key component of the immune system's response to pathogens, toxic agents, or tissue injury, involving stimulation defense mechanisms aimed removing pathogenic factors and restoring homeostasis. However, uncontrolled acute inflammatory may lead chronic inflammation, which involved in development many diseases, including cancer. Nowadays, need find new potential therapeutic compounds has raised worldwide scientific interest study marine environment. Specifically, microalgae are considered rich sources bioactive molecules, such as carotenoids, natural isoprenoid pigments with important beneficial effects for health due their biological activities. Carotenoids essential nutrients mammals, but they unable synthesize them; instead, dietary intake these required. classified carotenes (hydrocarbon carotenoids), α- β-carotene, xanthophylls (oxygenate derivatives) zeaxanthin, astaxanthin, fucoxanthin, lutein, β-cryptoxanthin, canthaxanthin. This review summarizes present up-to-date knowledge anti-inflammatory anticancer activities microalgal carotenoids both vitro vivo, well latest status human studies use prevention treatment diseases

Язык: Английский

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Antioxidant Activity, Metabolism, and Bioavailability of Polyphenols in the Diet of Animals

Antioxidants, Год журнала: 2023, Номер 12(6), С. 1141 - 1141

Опубликована: Май 23, 2023

As the world’s population grows, so does need for more and animal feed. In 2006, EU banned use of antibiotics other chemicals in order to reduce chemical residues food consumed by humans. It is well known that oxidative stress inflammatory processes must be combated achieve higher productivity. The adverse effects pharmaceuticals synthetic compounds on health product quality safety have increased interest phytocompounds. With plant polyphenols nutrition, they are gaining attention as a supplement Livestock feeding based sustainable, environmentally friendly approach (clean, safe, green agriculture) would also win–win farmers society. There an increasing producing healthier products origin with ratio polyunsaturated fatty acids (PUFAs) saturated modulating nutrition. Secondary metabolites (polyphenols) essential physiology involved various functions such growth, pigmentation, resistance pathogenic organisms. Polyphenols exogenous antioxidants act one first lines cell defense. Therefore, discoveries intracellular antioxidant activity contributed significantly improvement activity, prevent damage eliminate excessively produced free radicals. To welfare, medicines, increase origin, addition research breeding can practised part free-choice

Язык: Английский

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Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway

Chemosphere, Год журнала: 2022, Номер 307, С. 135662 - 135662

Опубликована: Июль 10, 2022

Язык: Английский

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Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment

Cell Proliferation, Год журнала: 2023, Номер 56(9)

Опубликована: Март 13, 2023

Abstract Low back pain (LBP) is a leading cause of labour loss and disability worldwide, it also imposes severe economic burden on patients society. Among symptomatic LBP, approximately 40% caused by intervertebral disc degeneration (IDD). IDD the pathological basis many spinal degenerative diseases such as herniation stenosis. Currently, therapeutic approaches for mainly include conservative treatment surgical treatment, neither which can solve problem from root terminating process (IVD). Therefore, further exploring pathogenic mechanisms adopting targeted strategies one current research hotspots. complex pathophysiological processes IDD, oxidative stress considered main factor. The delicate balance between reactive oxygen species (ROS) antioxidants essential maintaining normal function survival IVD cells. Excessive ROS levels damage to macromolecules nucleic acids, lipids, proteins cells, affect cellular activities functions, ultimately lead cell senescence or death. This review discusses potential role in understand provides IDD.

Язык: Английский

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