Oxidative Stress in Liver Pathophysiology and Disease

Antioxidants, Год журнала: 2023, Номер 12(9), С. 1653 - 1653

Опубликована: Авг. 22, 2023

The liver is an organ that particularly exposed to reactive oxygen species (ROS), which not only arise during metabolic functions but also the biotransformation of xenobiotics. disruption redox balance causes oxidative stress, affects function, modulates inflammatory pathways and contributes disease. Thus, stress implicated in acute injury pathogenesis prevalent infectious or chronic diseases such as viral hepatitis B C, alcoholic fatty disease, non-alcoholic disease (NAFLD) steatohepatitis (NASH). Moreover, plays a crucial role progression fibrosis, cirrhosis hepatocellular carcinoma (HCC). Herein, we provide overview on effects pathophysiology mechanisms by promotes

Язык: Английский

---

Submicron Dispersions of Phytosterols Reverse Liver Steatosis with Higher Efficacy than Phytosterol Esters in a Diet Induced-Fatty Liver Murine Model

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 564 - 564

Опубликована: Янв. 10, 2025

Consumption of phytosterols is a nutritional strategy employed to reduce cholesterol absorption, but recent research shows that their biological activity might go beyond reduction for the treatment metabolic dysfunction-associated fatty liver disease (MAFLD), and novel phytosterol formulations, such as submicron dispersions, could improve these effects. We explored therapeutic phytosterols, either formulated dispersions (SDPs) or conventional esters (PEs), in mouse model MAFLD. MAFLD was induced mice by atherogenic diet (AD) feeding. The reversion distorted serum parameter values after period AD feeding investigated supplementation with SDPs, PEs, placebo (PT). Additionally, parameters acid synthesis, oxidation, inflammation were studied understand mechanism action phytosterols. SDPs shown fat, along showing significant improvement triglycerides (TGs), free acids (FFAs), levels. These results reinforced analyses steatosis scores, histologies, where SDP intervention showed consistent improvement. Treatment PEs slighter effects same analyses, no observed PT treatment. reversed, higher efficacy than effect on levels TGs, total- LDL-cholesterol levels, glucose And, exceptionally, while improved HDL-cholesterol did not show any this parameter. provide evidence therapeutical regulation which increased when are compared ester formulations.

Язык: Английский

---

Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease

Cell Death and Disease, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 31, 2025

Язык: Английский

---

Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease

World Journal of Gastroenterology, Год журнала: 2022, Номер 28(48), С. 6909 - 6921

Опубликована: Дек. 26, 2022

Oxidative stress is a key driver in the development and progression of several diseases, including metabolic associated fatty liver disease (MAFLD). This condition includes wide spectrum pathological injuries, extending from simple steatosis to inflammation, fibrosis, cirrhosis, hepatocellular carcinoma. Excessive buildup lipids strictly related oxidative MAFLD, progressing fibrosis cirrhosis. The nuclear factor erythroid 2-related 2 (NRF2) master regulator redox homeostasis. NRF2 plays an important role for cellular protection by inducing expression genes antioxidant, anti-inflammatory, cytoprotective response. Consistent evidence demonstrates that involved every step MAFLD deve-lopment, advanced ini-tiation/progression activators regulate lipid metabolism alleviating genes. Thus, modulating activation crucial not only understanding specific mechanisms underlying but also characterize effective therapeutic strategies. review outlined current knowledge on effects pathway, modulators, implications steatosis, MAFLD.

Язык: Английский

---

The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease

Cell Metabolism, Год журнала: 2023, Номер 35(11), С. 1852 - 1871

Опубликована: Ноя. 1, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor for end-stage diseases with no available therapies. Dysregulated immune responses are critical culprits of MASLD pathogenesis. Independent contributions from either the innate or adaptive arms system their unidirectional interplay commonly studied in MASLD. However, bidirectional communication between and systems its impact on remain insufficiently understood. Given that both cells indispensable development progression inflammation MASLD, elucidating pathogenic stemming these two holds potential novel therapeutics Here, we review cell types pathways influence pathogenesis highlight pharmacologic approaches to combat based current knowledge this crosstalk.

Язык: Английский

---

Chinese herbal medicines: The modulator of nonalcoholic fatty liver disease targeting oxidative stress

Journal of Ethnopharmacology, Год журнала: 2023, Номер 318, С. 116927 - 116927

Опубликована: Июль 31, 2023

Язык: Английский

---

Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Май 12, 2023

Background: The incidence of glycolipid metabolic diseases is extremely high worldwide, which greatly hinders people’s life expectancy and patients’ quality life. Oxidative stress (OS) aggravates the development in metabolism. Radical oxygen species (ROS) a key factor signal transduction OS, can regulate cell apoptosis contribute to inflammation. Currently, chemotherapies are main method treat disorders metabolism, but this lead drug resistance damage normal organs. Botanical drugs an important source new drugs. They widely found nature with availability, practicality, low cost. There increasing evidence that herbal medicine has definite therapeutic effects on diseases. Objective: This study aims provide valuable for treatment botanical from perspective ROS regulation by further promote effective clinical Methods: Using herb*, plant medicine, Chinese phytochemicals, natural phytomedicine, extract, drug, ROS, free radicals, radical, oxidizing agent, glucose lipid saccharometabolism, glycometabolism, blood glucose, lipoprotein, triglyceride, fatty liver, atherosclerosis, obesity, diabetes, dysglycemia, NAFLD, DM as keywords or subject terms, relevant literature was retrieved Web Science PubMed databases 2013 2022 summarized. Results: regulating mitochondrial function, endoplasmic reticulum, phosphatidylinositol 3 kinase (PI3K)/protein B (AKT), erythroid 2-related 2 (Nrf-2), nuclear κB (NF-κB), other signaling pathways improve OS glucolipid Conclusion: multi-mechanism multifaceted. Both studies animal experiments have demonstrated effectiveness ROS. However, safety need be improved, more needed support application

Язык: Английский

---

Activation of Kupffer cells in NAFLD and NASH: mechanisms and therapeutic interventions

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Май 16, 2023

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are emerging as the leading causes of worldwide. These conditions can lead to cirrhosis, cancer, failure, other related ailments. At present, transplantation remains sole treatment option for end-stage NASH, a rapidly growing socioeconomic burden. Kupffer cells (KCs) dominant population macrophages that reside in liver, playing crucial role innate immunity. Their primary function includes phagocytosing exogenous substances, presenting antigens, triggering immune responses. Moreover, they interact with during pathogenesis NAFLD, this crosstalk may either delay or exacerbate progression. Stimulation by endogenous signals triggers activation KCs, resulting expression various inflammatory factors chemokines, such NLRP3, TNF-α, IL-1B, IL-6, contributing cascade. In past 5 years, significant advances have been made understanding biological properties functions KCs including their interactions tissue molecules, underlying molecular mechanisms, signaling pathways, relevant therapeutic interventions. Having comprehensive these mechanisms characteristics enormous potential guiding future strategies prevention NAFLD.

Язык: Английский

---

Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties

Plants, Год журнала: 2023, Номер 13(1), С. 20 - 20

Опубликована: Дек. 20, 2023

Moringa oleifera (M. oleifera) is a tropical tree native to Pakistan, India, Bangladesh, and Afghanistan; it cultivated for its nutritious leaves, pods, seeds. This scientific study was conducted outline the anti-inflammatory properties mechanisms of action bioactive compounds from M. oleifera. The existing research has found that plant used in traditional medicine due compounds, including phytochemicals: flavonoids polyphenols. are thought exert their effects to: (1) inhibition pro-inflammatory enzymes: quercetin kaempferol inhibit enzymes (cyclooxygenase lipoxygenase); (2) regulation cytokine production: isothiocyanates modulate signaling pathways involved inflammation, such as nuclear factor-kappa B (NF-kappa B) pathway; production cytokines TNF-α (tumor necrosis factor α) IL-1β (interleukin-1β); (3) antioxidant activity: contains flavonoids, polyphenols, known reduce oxidative stress inflammation. review includes oleifera’s on cardiovascular protection, anti-hypertensive activities, type 2 diabetes, inflammatory bowel disease, non-alcoholic fatty liver disease (NAFLD). could prove valuable exploring pharmacological potential contributing prospects developing effective medicines benefit human health.

Язык: Английский

---

Oxidative Stress and MicroRNAs in Endothelial Cells under Metabolic Disorders

Cells, Год журнала: 2023, Номер 12(9), С. 1341 - 1341

Опубликована: Май 8, 2023

Reactive oxygen species (ROS) are radical intermediates that serve as important second messengers in signal transduction. However, when the accumulation of these molecules exceeds buffering capacity antioxidant enzymes, oxidative stress and endothelial cell (EC) dysfunction occur. EC shifts vascular system into a pro-coagulative, proinflammatory state, thereby increasing risk developing cardiovascular (CV) diseases metabolic disorders. Studies have turned to investigation microRNA treatment for CV factors, post-transcription regulators known co-regulate ROS. In this review, we will discuss ROS pathways generation, normal physiology ROS-induced dysfunction, current knowledge common disorders their connection stress. Therapeutic strategies based on microRNAs response microRNA’s regulatory roles controlling also be explored. It is gain an in-depth comprehension mechanisms generating how manipulating enzymatic byproducts can protect function from prevent development

Язык: Английский

---