Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

Frontiers in Oncology, Год журнала: 2021, Номер 11

Опубликована: Апрель 27, 2021

Digestive system cancer tumors are one of the major causes cancer-related fatalities; vast majority them colorectal or gastric malignancies. Epidemiological evidence confirmed that allium-containing food, such as garlic, reduces risk developing Among all compounds in allicin has been most researched, it contains sulfur and produces many second degradation compounds, dioxide, diallyl sulfide (DAS), trisulfide (DATS), disulfide (DADS) presence enzymatic reactions juice. These substances have shown anti-inflammatory, antidiabetic, antihypertensive, antifungal, antiviral, antibacterial, anticancer efficacy, including gastrointestinal (GI) cancers, leukemia, skin cancers. Herein, we summarize therapeutic potential treatment GI

Язык: Английский

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Mechanistic inhibition of gastric cancer-associated bacteria Helicobacter pylori by selected phytocompounds: A new cutting-edge computational approach

Heliyon, Год журнала: 2023, Номер 9(10), С. e20670 - e20670

Опубликована: Окт. 1, 2023

Helicobacter pylori (H. pylori) is a persistent bacterial inhabitant in the stomachs of approximately half global populace. This bacterium directly linked to chronic gastritis, leading heightened risk duodenal and gastric ulcer diseases, predominant factor for cancer - second most common cause cancer-related deaths globally. The increasing prevalence antibiotic resistance necessitates exploration innovative treatment alternatives mitigate H. menace.Initiating our study, we curated list thirty phytochemicals based on previous literature subjected them molecular docking studies. Subsequently, eight phytocompounds-Glabridin, Isoliquiritin, Sanguinarine, Liquiritin, Glycyrrhetic acid, Beta-carotin, Diosgenin, Sarsasapogenin-were meticulously chosen superior binding scores. These were further an extensive computational analysis encompassing ADMET profiling, drug-likeness evaluation, principal component (PCA), dynamic simulations (MDs) comparison with conventional drug, Mitomycin.The natural compounds investigated demonstrated affinities targets compared standard Mitomycin. Notably, phytocompounds Diosgenin Sarsasapogenin stood out due their exceptional pharmacokinetic properties, including favorable profiles.Our comprehensive technologically-advanced approach showcases potential identified as pioneering therapeutic agents against pylori-induced malignancies. In light promising silico results, recommend these candidates advancing pylori-targeted drug development. Given potential, strongly advocate subsequent vitro vivo studies validate efficacy this formidable gastrointestinal bacterium.

Язык: Английский

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Interaction of polyelectrolyte-shell cubosomes with serum albumin for triggering drug release in gastrointestinal cancer

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(11), С. 2490 - 2503

Опубликована: Янв. 1, 2023

Biopolymers-tailored cubosomes in contact with albumin endure phase change leading to release of encapsulated content which may provide effective drug digestive cancer treatments.

Язык: Английский

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Curcumin nanopreparations: recent advance in preparation and application

Biomedical Materials, Год журнала: 2024, Номер 19(5), С. 052009 - 052009

Опубликована: Авг. 27, 2024

Abstract Curcumin is a natural polyphenolic compound extracted from turmeric with antibacterial, antioxidant, antitumor, preventive and therapeutic neurological disorders variety of bioactivities, which widely used in the field food medicine. However, drawbacks curcumin such as poor aqueous solubility stability have limited practical application curcumin. To overcome these defects enhance its functional properties, various nanoscale systems (liposomes, polymer nanoparticles, protein solid lipid metal etc) been extensively employed for encapsulation delivery. Despite rapid development nanoformulations, there lack comprehensive reviews on their preparation properties. This review provides an overview construction nano-delivery systems, mechanisms action, nanocarrier methods applications nanocarriers pharmaceutical fields to provide theoretical basis technological support efficient bio-utilization, product early clinical

Язык: Английский

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Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(18), С. 6555 - 6555

Опубликована: Сен. 8, 2020

Anthocyanins are a group of dietary polyphenols, abundant mainly in fruits and their products. Dietary interventions anthocyanins being studied extensively related to the prevention gastrointestinal (GI) cancer, among many other chronic disorders. This review summarizes hereditary non-hereditary characteristics GI cancers, chemistry, bioavailability anthocyanins, most recent findings anthocyanin cancer through modulating cellular signaling pathways. cancer-preventive attributes primarily due antioxidative, anti-inflammatory, anti-proliferative properties, ability regulate gene expression metabolic pathways, as well induce apoptosis cells.

Язык: Английский

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Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice

Carcinogenesis, Год журнала: 2020, Номер 42(2), С. 210 - 219

Опубликована: Сен. 16, 2020

Fucoxanthin (Fx), a marine carotenoid found in edible brown algae, is well known for having anticancer properties. The gut microbiota has been demonstrated as hallmark colorectal cancer progression both humans and rodents. However, it remains unclear whether the associated with effect of Fx. We investigated chemopreventive potency Fx its on mouse model inflammation-associated (by azoxymethane/dextran sulfate sodium treatment). administration (30 mg/kg bw) during 14 week period significantly inhibited multiplicity adenocarcinoma mice. number apoptosis-like cleaved caspase-3high cells increased colonic mucosal crypts. suppressed Bacteroidlales (f_uc; g_uc) (0.3-fold) Rikenellaceae (g_uc) (0.6-fold) Lachnospiraceae (2.2-fold), compared those control Oral fecal suspension obtained from Fx-treated mice, aimed to enhance Lachnospiraceae, suppress adenocarcinomas sodium-treated mice successful increase gut. Our findings suggested that an alteration by dietary might be essential factor

Язык: Английский

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Pectin-Tannic Acid Nano-Complexes Promote the Delivery and Bioactivity of Drugs in Pancreatic Cancer Cells

Pharmaceutics, Год журнала: 2020, Номер 12(3), С. 285 - 285

Опубликована: Март 22, 2020

Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of successful nanomedicine-based therapeutic regimen with augmented efficacy highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cells. Herein, we developed used an innovative approach stable nanocomplexes based on tannic acid (MPT-NCs). The nanocomplex formation was enabled by strong intermolecular interactions between under very mild conditions. These were characterized particle size morphology (DLS, TEM, SEM), FT-IR spectroscopy, zeta potential measurements. Additionally, MPT-NCs capable encapsulating anticancer drugs (5-fluorouracil, gemcitabine, irinotecan) through binding. in vitro bioactivity these evaluated pancreatic adenocarcinoma (PDAC) cell lines (HPAF-II PANC-1). A dose-dependent internalization evident from microscopy flow cytometry analysis. Both proliferation colony assays indicated against PDAC cells compared that free treatments. Together, could be reliable efficient strategy therapy.

Язык: Английский

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Phytochemicals in cancer and their effect on the PI3K/AKT-mediated cellular signalling

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 139, С. 111650 - 111650

Опубликована: Май 1, 2021

Protein kinases belong to the largest family of enzymes controlling every aspect cellular activity including gene expression, cell division, differentiation and metabolism. They are part major intracellular signalling pathways. Hence, it is not surprising that they involved in development diseases such as cardiovascular disorders, diabetes, dementia and, most importantly, cancer when undergo mutations, modifications unbalanced expression. This review will explore possibility draw a connection between application natural phytochemicals treatment cancer. We have chosen focus on PI3K/AKT pathway which has been shown be target by compounds cultures animal models.

Язык: Английский

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Luteolin Synergistically Enhances Antitumor Activity of Oxaliplatin in Colorectal Carcinoma via AMPK Inhibition

Antioxidants, Год журнала: 2022, Номер 11(4), С. 626 - 626

Опубликована: Март 24, 2022

Luteolin is a naturally-occurring polyphenolic compound that known to have antioxidative and antitumor activities in vitro. This study aimed examine the vivo anticancer efficacy of luteolin conjunction with oxaliplatin treatment using colorectal carcinoma xenograft mouse model. HCT116 human cells were subcutaneously implanted into BALB/c nude mice, followed by intraperitoneal administration at dose 50 mg/kg body weight (BW)/day or without 10 BW/day three times per week for total 3 weeks. The combined resulted synergistic suppression growth tumors when compared alone. In addition, significantly increased expression cleaved PARP p53 vehicle control, but only marginally affected level heme oxygenase-1 (HO-1). These results indicated retarded oxaliplatin-induced tumor facilitating apoptotic cell death inhibiting HO-1-mediated cytoprotection. Therefore, these findings suggest potential dietary conventional chemotherapy cancer.

Язык: Английский

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Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

Phytotherapy Research, Год журнала: 2024, Номер 38(3), С. 1329 - 1344

Опубликована: Янв. 9, 2024

Abstract Cancer is a highly heterogeneous disease that poses serious threat to human health worldwide. Despite significant advances in the diagnosis and treatment of cancer, prognosis survival rate cancer remain poor due late diagnosis, drug resistance, adverse reactions. Therefore, it very necessary study development mechanism formulate effective therapeutic interventions. As widely available bioactive substances, natural products have shown obvious anticancer potential, especially by targeting abnormal epigenetic changes. The main active part garlic organic sulfur compounds, which diallyl trisulfide (DATS) content highest, accounting for more than 40% total composition. garlic‐derived compounds been recognized as an antioxidant prevention treatment. However, molecular antitumor effect remains unclear. Recent studies identified compound DATS plays critical roles enhancing CpG demethylation or promoting histone acetylation inhibitor. Here, we review progress against through pathways.

Язык: Английский

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