Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 1 - 34
Опубликована: Янв. 1, 2025
Язык: Английский
International Journal of Oncology, Год журнала: 2024, Номер 64(3)
Опубликована: Янв. 19, 2024
Gastric cancer is one of the most common malignancies and has relatively high morbidity mortality rates. Exosomes are nanoscale extracellular vesicles that originate from a diverse array cells may be found throughout various bodily fluids. These endogenous nanocarriers in their natural state with unique ability to transport lipids, proteins, DNA RNA. contain DNA, RNA, lipids other bioactive components have crucial roles transmission information regulation cell activities gastric cancer. This paper begins an exploration composition, formation release mechanisms exosomes. Subsequently, role exosomes tumor microenvironment reviewed terms immune population, nonimmune population factors. Finally, current status challenges exosome‑based research on progression, diagnosis therapeutic methods summarized. holistic review offers insight guide future directions for potentially pave way novel interventions management
Язык: Английский
Процитировано
6
Cellular and Molecular Biology, Год журнала: 2024, Номер 70(3), С. 174 - 181
Опубликована: Март 31, 2024
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8423 - 8423
Опубликована: Авг. 1, 2024
The most abundant tripeptide—glutathione (GSH)—and the major GSH-related enzymes—glutathione peroxidases (GPxs) and glutathione S-transferases (GSTs)—are highly significant in regulation of tumor cell viability, initiation development, its progression, drug resistance. high level GSH synthesis different cancer types depends not only on increasing expression key enzymes γ-glutamyl cycle but also changes transport velocity precursor amino acids. ability GPxs to reduce hydroperoxides is used for cellular each member GPx family has a mechanism action site maintaining redox balance. GSTs catalyze conjugation electrophilic substances reduction organic take part signaling pathways. By catalyzing S-glutathionylation target proteins, are involved processes, including metabolism (e.g., glycolysis PPP), signal transduction, transcription regulation, development resistance anticancer drugs. In this review, recent findings synthesis, roles functions GPxs, GST isoforms discussed, along with search inhibitors treatment.
Язык: Английский
Процитировано
5
Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Год журнала: 2024, Номер 293, С. 111626 - 111626
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
4
Animals, Год журнала: 2024, Номер 14(8), С. 1218 - 1218
Опубликована: Апрель 18, 2024
Good practices in farm animal care are crucial for upholding well-being, efficiency, and health. Pigs, like other animals, exposed to various stressors, including environmental, nutritional, chemical, psychological, physiological, metabolic which can disrupt their internal balance compromise well-being. Oxidative stress adversely affect performance, fertility, immunity, leading economic losses farmers. Dietary considerations hugely important attaining these objectives. This paper reviews studies investigating the impact of additional vitamin supplementation on reduction pigs. Vitamin A be beneficial counteracting viral parasitic threats. B a potential solution reproductive issues, but it might also reducing effects inappropriate nutrition. C plays vital role heat or exposure toxins D proves addressing induced mostly by infections weaning, while E has been shown mitigate toxins, stress, transport stress. review highlights benefits dietary antioxidants maintaining pig health, enhancing productivity, adverse stressors. Understanding vitamins nutrition management is optimising welfare production efficiency.
Язык: Английский
Процитировано
4
Сибирский научный медицинский журнал, Год журнала: 2025, Номер 44(6), С. 128 - 137
Опубликована: Янв. 8, 2025
Reactive oxygen metabolites and antioxidants, as well the redox-sensitive signaling Nrf2-dependent pathway, play a dual role in formation, growth progression of malignant neoplasms. The aim study was to investigate ability original synthetic monophenolic antioxidant combined action influence tumor vivo side effects cytostatic use. Material methods . Lewis lung carcinoma (LLC) used an experimental model growth. performed on 120 female C57Bl/6 mice, which were divided into 12 groups; animals weighed weekly. Mice corresponding groups received intragastrically solution sodium 3-(3′- tert -butyl-4′-hydroxyphenyl)propylthiosulfonate (TS-13) (100 mg/kg body weight), suspension -butylhydroquinone (tBHQ) or solvent (0.9% NaCl solution) throughout experiment. 28 days after start TS-13 tBHQ administration, mice implanted intramuscularly with LLC cells at dose 2×10 5 cells/mouse; 7th 14th development, doxorubicin administered intraperitoneally twice cumulative 8 weight (4/5 LD10). On 35th day growth, removed from experiment, extracted, its linear dimensions determined; mass coefficient volume calculated, respectively. spleen also estimated. Results discussion receiving statistically significantly greater than that other carriers. Administration inhibited effectively doxorubicin, more when combination; did not exert independent inhibitory effect, enhance effect combination cytostatic. Doxorubicin reduced coefficient, while Monotherapy accompanied by hair loss dorsal surface (8 out 10), no alopecia observed administration tBHQ. Conclusions Monophenol TS-13, direct inducer Keap1/Nrf2/ARE system, is comparable terms antitumor effect. use allows reduce negative manifestations associated chemotherapy, such cachexia, splenotoxity, alopecia.
Язык: Английский
Процитировано
0
Journal of Fluorescence, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(2), С. 148 - 148
Опубликована: Янв. 27, 2025
Licochalcone A (LicoA) possesses anti-tumor properties. However, the potential therapeutic effect of LicoA on uterine leiomyomas (ULs) remains unknown. In this study, effects proliferation ULs and its underlying mechanism were explored. treatment significantly decreased viability smooth muscle cells (UtSMCs) ELT3 in a dose-dependent manner. The induction cell apoptosis by was accompanied increased generation reactive oxygen species (ROS), elevated endoplasmic reticulum (ER) stress (GRP78/IRE1α/ATF6/CHOP), expression proapoptotic proteins (c-caspase-3, c-caspase-9, c-PARP). ability Z-VAD-FMK (a caspase inhibitor) n-acetylcysteine (NAC; membrane permeable antioxidant) to reverse LicoA-induced ROS-mediated ER pathways also observed. Furthermore, GRP78 or JNK knockdown involved cells. immunodeficient mice, suppressed growth tumor cells, without toxicity. This study is first show that exerts anti-leiomyoma via modulation stress-induced through JNK/GRP78/NRF2 signaling pathway.
Язык: Английский
Процитировано
0
Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 750, С. 151424 - 151424
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(2), С. 180 - 180
Опубликована: Фев. 4, 2025
The retinal pigment epithelium (RPE) is a highly specialised monolayer subjected to constant oxidative stress, which, in the long term, favours development of complex pathological process that underlying cause macular damage. Therefore, counteracting overproduction ROS best-researched approach preserve functional integrity RPE. S-Petasin, secondary metabolite extracted from plant Petasites hybridus, has numerous biological effects, which highlight its anti-inflammatory and antioxidative properties. aim our study investigate whether S-Petasin exerts cytoprotective effects by protecting RPE pretreatment with were assessed determination cell viability, intracellular levels, activation Nrf2 pathway resulting post-transcriptional antioxidant/antiapoptotic response. Our results show (1) reduces improving viability exposed damage; (2) activates signalling pathway, modulating response antioxidant chemical biomarkers; (3) Bax an increase those Bcl-2, concomitant downregulation Bax/Bc-2 ratio. Overall, provide first evidence able protect
Язык: Английский
Процитировано
0