Collagen as a Biomaterial for Skin and Corneal Wound Healing

Journal of Functional Biomaterials, Год журнала: 2022, Номер 13(4), С. 249 - 249

Опубликована: Ноя. 16, 2022

The cornea and the skin are two organs that form outer barrier of human body. When either is injured (e.g., from surgery, physical trauma, or chemical burns), wound healing initiated to restore integrity. Many cells activated during healing. In particular, fibroblasts stimulated often transition into repair myofibroblasts synthesize extracellular matrix (ECM) components area. Control ECM deposition critical, as a disorganized can block restoration function. One most abundant structural proteins in mammalian collagen. Collagen type I main component connective tissues. It be readily obtained purified, short analogs have also been developed for tissue engineering applications, including modulating response. This review discusses effect several current collagen implants on stimulation corneal These range sponges hydrogels films membranes.

Язык: Английский

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Hydrogel-based dressings designed to facilitate wound healing

Materials Advances, Год журнала: 2023, Номер 5(4), С. 1364 - 1394

Опубликована: Дек. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Язык: Английский

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Autophagy is the key to making chronic wounds acute in skin wound healing

Autophagy, Год журнала: 2023, Номер 19(9), С. 2578 - 2584

Опубликована: Март 30, 2023

As a highly regulated and dynamically balanced intracellular degradation mechanism, macroautophagy/autophagy plays an essential housekeeping role in different successive stages of skin wound healing; from the homeostasis inflammatory to proliferative remodeling stages. Under both progressive defective healing conditions, autophagy operates at levels with precise extent activity, interface inflammation, stress signaling cell metabolism through complex spatiotemporal cascade molecular cellular events. Depending on conditions autophagic activity is fine-tuned differentially modulated each stage order cope stage-specific requirements. Here, we postulate that under favorable may act as key modulator by making chronic wounds acute. Enhancing topical application pro-autophagy biologics appropriate hydrating vehicle/moisturizing base such hydrogels, onto provide moisture immune modulation, thus contributing rapid efficient healing. A moist environment more conducive it helps not only accelerate proliferation migration, extracellular matrix reorganization, but also promotes reduces incidence inflammation.

Язык: Английский

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Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116497 - 116497

Опубликована: Март 28, 2024

The study of chemicals extracted from natural sources should be encouraged due to the significant number cancer deaths each year and financial burden imposed by this disease on society. causes almost all cancers involve a combination lifestyle, environmental factors, genetic inherited factors. Modern medicine researchers are increasingly interested in traditional phytochemicals as they hold potential for new bioactive compounds with medical applications. Recent publications have provided evidence antitumor properties phytochemicals, key component Chinese medicine, thereby opening avenues their use modern medicine. Various studies demonstrated strong correlation between apoptosis autophagy, two critical mechanisms involved formation regulation, indicating diverse forms crosstalk them. Phytochemicals ability activate both pro-apoptotic pro-autophagic pathways. Therefore, understanding how influence relationship autophagy is crucial developing treatment strategy that targets these molecular mechanisms. This review aims explore anticancer effects, focusing role regulating which contributes uncontrolled tumor cell growth. Additionally, highlights limitations challenges current research methodologies while suggesting future field.

Язык: Английский

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Exploiting Matrix Stiffness to Overcome Drug Resistance

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 4682 - 4700

Опубликована: Июль 5, 2024

Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding underlying mechanisms drug in tumor progression and metastasis are essential developing better treatment modalities. Given matrix stiffness affecting mechanotransduction capabilities cells, characterization related signal transduction pathways can provide a understanding for novel therapeutic strategies. In this review, we aimed to summarize recent advancements biology parallel approaches targeting its consequences cellular processes metastasis. The governed by their aberrant activation may result activating epithelial-to-mesenchymal transition, stemness, autophagy, which be attributed resistance. Developing strategies target these will offer tailor personalized modalities clinical studies.

Язык: Английский

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P75NTR regulates autophagy through the YAP-mTOR pathway to increase the proliferation of interfollicular epidermal cells and promote wound healing in diabetic mice

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(3), С. 167012 - 167012

Опубликована: Янв. 3, 2024

Wound healing is delayed in diabetic patients. Increased autophagy and dysfunction of interfollicular epidermal (IFE) cells are closely associated with wounds. Autophagy plays an important role all stages wound healing, but its the underlying molecular mechanisms not clear. Here, we found that mice had increased wounds compared normal chloroquine, inhibitor autophagy, decreased level improved function IFE cells, accelerated mice. Treatment advanced glycosylation end products (AGEs) resulted microtubule-associated protein chain (LC3) expression prostacyclin-62 (P62) expression, indicating AGE-treated cells. Moreover, P75NTR reduced presence AGEs significantly proliferation In addition, participated regulating through YAP-mTOR signalling pathway, which functional activity rate Thus, our study suggests protects against by affecting accelerating mice, providing a basis for understanding healing.

Язык: Английский

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Autophagy in Tissue Repair and Regeneration

Cells, Год журнала: 2025, Номер 14(4), С. 282 - 282

Опубликована: Фев. 14, 2025

Autophagy is a cellular recycling system that, through the sequestration and degradation of intracellular components regulates multiple functions to maintain homeostasis survival. Dysregulation autophagy closely associated with development physiological alterations human diseases, including loss regenerative capacity. Tissue regeneration highly complex process that relies on coordinated interplay several processes, such as injury sensing, defense responses, cell proliferation, differentiation, migration, senescence. These processes act synergistically repair or replace damaged tissues restore their morphology function. In this review, we examine evidence supporting involvement pathway in different mechanisms comprising across contexts. Additionally, explore how modulating can enhance accelerate repair, highlighting promising therapeutic target medicine for autophagy-based treatments diseases.

Язык: Английский

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Effect of Chemical Injury on Autophagy in Canine Corneal Stromal Fibroblasts

Journal of Ocular Pharmacology and Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Purpose: Ocular trauma leads to loss of corneal clarity resulting in vision deficits. Autophagy plays a critical role the extracellular matrix, tissue repair, and homeostasis but its precise mechanistic regulating function remains unknown. The present study investigated modulation autophagy-related genes (LC3, Beclin1, Sqstm1/p62, Lamp1) healthy injured canine stromal fibroblasts (CSFs).

Язык: Английский

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Conditioned media of stem cells from human exfoliated deciduous teeth contain factors related to extracellular matrix organization and promotes corneal epithelial wound healing

Regenerative Therapy, Год журнала: 2025, Номер 29, С. 148 - 161

Опубликована: Март 18, 2025

Язык: Английский

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Cu‐Intercalated MoS₂ Nanosheets with Enhanced Antibacterial Activity for Treatment of Bacterial Keratitis

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Bacterial keratitis (BK) is a critical and sight-threatening corneal infection that significantly impairs the quality of life. Due to widespread antibiotic-resistant microbes slow development in antibiotics, there an increasingly growing demand create new antimicrobial agents for treatment BK. Herein, copper-intercalated molybdenum disulfide (Cu-MoS2) nanosheets are constructed by intercalating Cu into interlayer structure MoS2 via intercalation chemistry, which not only introduces Fenton reaction but also modulates electronic MoS2. Cu-MoS2 can convert H2O2 more toxic reactive oxygen species (ROS), thereby exhibiting excellent bactericidal performance against Staphylococcus aureus (S. aureus), methicillin-resistant (MRSA) Escherichia coli (E. coli) at room temperature dark. Animal experiments indicated effectively treat BK caused MRSA. This work demonstrates chemistry as novel effective strategy tune antibacterial agent with no reliance on light has great potential therapeutic effects clinical drug-resistant

Язык: Английский

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